The specific contributions of set‐shifting to freezing of gait in Parkinson's disease
Identifieur interne : 001948 ( Main/Curation ); précédent : 001947; suivant : 001949The specific contributions of set‐shifting to freezing of gait in Parkinson's disease
Auteurs : Sharon L. Naismith [Australie] ; James M. Shine [Australie] ; Simon J. G. Lewis [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-06-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Congélation.
English descriptors
- KwdEn :
- Aged, Attention (physiology), Executive function, Female, Freezing, Gait Disorders, Neurologic (complications), Gait Disorders, Neurologic (etiology), Humans, Male, Memory Disorders (etiology), Memory, Short-Term (physiology), Mental Status Schedule, Middle Aged, Multivariate Analysis, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson disease, Parkinson's disease, Planning, Regression Analysis, Severity of Illness Index, Working memory, executive function, freezing of gait, planning, set‐shifting, working memory.
- MESH :
- complications : Gait Disorders, Neurologic, Parkinson Disease.
- etiology : Gait Disorders, Neurologic, Memory Disorders.
- physiology : Attention, Memory, Short-Term.
- Aged, Female, Humans, Male, Mental Status Schedule, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Regression Analysis, Severity of Illness Index.
Abstract
Freezing of gait (FOG) in Parkinson's disease (PD) is common and the pathophysiology of FOG is poorly understood. It has been hypothesized to reflect complementary yet competing frontostriatal pathways that reduce the ability to keep different tasks (motor or cognitive) on‐line. This inability to “set‐shift” has been proposed to trigger a freezing episode. If correct, this hypothesis would predict a differential pattern of executive dysfunction with FOG being most specifically related to attentional set‐shifting. In this study, 31 patients with a range of self‐reported FOG symptom severities were administered tests of executive functioning. The results demonstrate that FOG symptoms were selectively correlated with poorer performance on tasks of set‐shifting, but not with a range of other executive tasks. This was apparent even after controlling for slowed processing speed, disease stage and depressive symptoms. The results support the recently proposed hypothesis for the pathophysiology underlying FOG in PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23005
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<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Neuropsychological Tests</term>
<term>Regression Analysis</term>
<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en">Freezing of gait (FOG) in Parkinson's disease (PD) is common and the pathophysiology of FOG is poorly understood. It has been hypothesized to reflect complementary yet competing frontostriatal pathways that reduce the ability to keep different tasks (motor or cognitive) on‐line. This inability to “set‐shift” has been proposed to trigger a freezing episode. If correct, this hypothesis would predict a differential pattern of executive dysfunction with FOG being most specifically related to attentional set‐shifting. In this study, 31 patients with a range of self‐reported FOG symptom severities were administered tests of executive functioning. The results demonstrate that FOG symptoms were selectively correlated with poorer performance on tasks of set‐shifting, but not with a range of other executive tasks. This was apparent even after controlling for slowed processing speed, disease stage and depressive symptoms. The results support the recently proposed hypothesis for the pathophysiology underlying FOG in PD. © 2010 Movement Disorder Society</div>
</front>
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