Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease
Identifieur interne : 001455 ( Main/Curation ); précédent : 001454; suivant : 001456Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease
Auteurs : Bart Post [Pays-Bas] ; Dino Muslimovic [Pays-Bas] ; Nan Van Geloven [Pays-Bas] ; Johannes D. Speelman [Pays-Bas] ; Ben Schmand [Pays-Bas] ; Rob J. De Haan [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Disability, Disability Evaluation, Disease Progression, Female, Humans, Linear Models, Male, Middle Aged, Nervous system diseases, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Prognosis, Quality of Life, Quality of life, Retrospective Studies, Severity of Illness Index, disability, motor impairment, prognosis, quality of life.
- MESH :
- diagnosis : Parkinson Disease.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Disability Evaluation, Disease Progression, Female, Humans, Linear Models, Male, Middle Aged, Prognosis, Quality of Life, Retrospective Studies, Severity of Illness Index.
Abstract
Objective:: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods:: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results:: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions:: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23467
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Speelman</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Haan, Rob J" sort="De Haan, Rob J" uniqKey="De Haan R" first="Rob J." last="De Haan">Rob J. De Haan</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="449">449</biblScope><biblScope unit="page" to="456">456</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">47C967592FC8FB1AAC2BB5254412CB834E74D1D5</idno><idno type="DOI">10.1002/mds.23467</idno><idno type="ArticleID">MDS23467</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disability</term><term>Disability Evaluation</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prognosis</term><term>Quality of Life</term><term>Quality of life</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>disability</term><term>motor impairment</term><term>prognosis</term><term>quality of life</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disability Evaluation</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Quality of Life</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Incapacité</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Pronostic</term><term>Qualité de vie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective:: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods:: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results:: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions:: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society</div></front></TEI><double idat="0885-3185:2011:Post B:progression:and:prognostic"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Progression and Prognostic Factors of Motor Impairment, Disability and Quality of Life in Newly Diagnosed Parkinson's Disease</title><author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Radboud University Nijmegen Medical Center</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Muslimovic, Dino" sort="Muslimovic, Dino" uniqKey="Muslimovic D" first="Dino" last="Muslimovic">Dino Muslimovic</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology and Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Geloven, Nan" sort="Van Geloven, Nan" uniqKey="Van Geloven N" first="Nan" last="Van Geloven">Nan Van Geloven</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology and Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology and Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Haan, Rob J" sort="De Haan, Rob J" uniqKey="De Haan R" first="Rob J." last="De Haan">Rob J. De Haan</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0211298</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0211298 INIST</idno><idno type="RBID">Pascal:11-0211298</idno><idno type="wicri:Area/PascalFrancis/Corpus">000672</idno><idno type="wicri:Area/PascalFrancis/Curation">002646</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000441</idno><idno type="wicri:doubleKey">0885-3185:2011:Post B:progression:and:prognostic</idno><idno type="wicri:Area/Main/Merge">001A31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Progression and Prognostic Factors of Motor Impairment, Disability and Quality of Life in Newly Diagnosed Parkinson's Disease</title><author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Radboud University Nijmegen Medical Center</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Muslimovic, Dino" sort="Muslimovic, Dino" uniqKey="Muslimovic D" first="Dino" last="Muslimovic">Dino Muslimovic</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology and Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Geloven, Nan" sort="Van Geloven, Nan" uniqKey="Van Geloven N" first="Nan" last="Van Geloven">Nan Van Geloven</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology and Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology and Clinical Neurophysiology, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Haan, Rob J" sort="De Haan, Rob J" uniqKey="De Haan R" first="Rob J." last="De Haan">Rob J. De Haan</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disability</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Prognosis</term><term>Quality of life</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Pronostic</term><term>Incapacité</term><term>Qualité de vie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3-year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor-Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow-up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow-up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self-reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL.</div></front></TEI></INIST><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title><author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name></author><author><name sortKey="Muslimovic, Dino" sort="Muslimovic, Dino" uniqKey="Muslimovic D" first="Dino" last="Muslimovic">Dino Muslimovic</name></author><author><name sortKey="Van Geloven, Nan" sort="Van Geloven, Nan" uniqKey="Van Geloven N" first="Nan" last="Van Geloven">Nan Van Geloven</name></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name></author><author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name></author><author><name sortKey="De Haan, Rob J" sort="De Haan, Rob J" uniqKey="De Haan R" first="Rob J." last="De Haan">Rob J. De Haan</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:47C967592FC8FB1AAC2BB5254412CB834E74D1D5</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23467</idno><idno type="url">https://api.istex.fr/document/47C967592FC8FB1AAC2BB5254412CB834E74D1D5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000456</idno><idno type="wicri:Area/Istex/Curation">000456</idno><idno type="wicri:Area/Istex/Checkpoint">000187</idno><idno type="wicri:doubleKey">0885-3185:2011:Post B:progression:and:prognostic</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:21312273</idno><idno type="wicri:Area/PubMed/Corpus">001458</idno><idno type="wicri:Area/PubMed/Curation">001458</idno><idno type="wicri:Area/PubMed/Checkpoint">001147</idno><idno type="wicri:Area/Ncbi/Merge">002F62</idno><idno type="wicri:Area/Ncbi/Curation">002F62</idno><idno type="wicri:Area/Ncbi/Checkpoint">002F62</idno><idno type="wicri:Area/Main/Merge">001508</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease</title><author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Muslimovic, Dino" sort="Muslimovic, Dino" uniqKey="Muslimovic D" first="Dino" last="Muslimovic">Dino Muslimovic</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Geloven, Nan" sort="Van Geloven, Nan" uniqKey="Van Geloven N" first="Nan" last="Van Geloven">Nan Van Geloven</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Schmand, Ben" sort="Schmand, Ben" uniqKey="Schmand B" first="Ben" last="Schmand">Ben Schmand</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Haan, Rob J" sort="De Haan, Rob J" uniqKey="De Haan R" first="Rob J." last="De Haan">Rob J. De Haan</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="449">449</biblScope><biblScope unit="page" to="456">456</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">47C967592FC8FB1AAC2BB5254412CB834E74D1D5</idno><idno type="DOI">10.1002/mds.23467</idno><idno type="ArticleID">MDS23467</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disability Evaluation</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Parkinson's disease</term><term>Prognosis</term><term>Quality of Life</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>disability</term><term>motor impairment</term><term>prognosis</term><term>quality of life</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disability Evaluation</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Quality of Life</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective:: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. Methods:: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3‐year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor‐Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. Results:: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow‐up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow‐up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self‐reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. Conclusions:: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL. © 2011 Movement Disorder Society</div></front></TEI></ISTEX></double></record>Pour manipuler ce document sous Unix (Dilib)
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