Imaging nigral pathology and clinical progression in Parkinson's disease
Identifieur interne : 000D57 ( Main/Curation ); précédent : 000D56; suivant : 000D58Imaging nigral pathology and clinical progression in Parkinson's disease
Auteurs : Guangwei Du [États-Unis] ; Mechelle M. Lewis [États-Unis] ; Suman Sen [États-Unis] ; Jianli Wang [États-Unis] ; Michele L. Shaffer [États-Unis] ; Martin Styner [États-Unis] ; Qing X. Yang [États-Unis] ; Xuemei Huang [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- pathology : Parkinson Disease, Substantia Nigra.
- physiopathology : Parkinson Disease.
- Aged, Analysis of Variance, Diffusion Magnetic Resonance Imaging, Disease Progression, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
The pattern of dopamine cell loss in Parkinson's disease is known to be prominent in the ventrolateral and caudal substantia nigra, but less severe in the dorsal and rostral region. Both diffusion tensor imaging and R2* relaxometry of the substantia nigra have been reported as potential markers for Parkinson's disease, but their relative ability to mark disease progression and differences in pathophysiological bases remains unclear.
High resolution T2-weigthed, R2*, and diffusion tensor imaging were obtained from 28 controls and 40 Parkinson's disease subjects [15 early-stage (disease duration≤1 year), 14 mid-stage (duration 2-5 years), and 11 late-stage (duration>5 years)]. Fractional anisotropy and R2* values in both rostral and caudal substantia nigra were obtained for all subjects, and clinical measures (disease duration; levodopa-equivalent daily dosage; “off”-drug Unified Parkinson's Disease Rating Scale motor score) were obtained for Parkinson's subjects.
There was no correlation between fractional anisotropy and clinical measures, whereas R2* was strongly associated with disease progression. Compared to controls, fractional anisotropy in caudal substantia nigra was significantly decreased in Parkinson's disease patients of all stages, whereas in rostral substantia nigra it was decreased significantly only in the late-stage group. R2* in both substantia nigra regions was significantly increased in the mid-stage and late-stage, but not early-stage, of Parkinson's disease subjects.
These findings suggest that fractional anisotropy changes may mark early pathological changes in caudal substantia nigra, whereas the changes in R2* may more closely track Parkinson's disease's clinical progression after symptom onset.
Url:
DOI: 10.1002/mds.25182
PubMed: 23008179
PubMed Central: 3510346
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<author><name sortKey="Yang, Qing X" sort="Yang, Qing X" uniqKey="Yang Q" first="Qing X." last="Yang">Qing X. Yang</name>
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<placeName><region type="state">Pennsylvanie</region>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
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<wicri:cityArea>Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea>
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<author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
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<wicri:cityArea>Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A3">Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
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<wicri:cityArea>Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
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<wicri:cityArea>Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A5">Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology, University of North Carolina, Chapel Hill, NC 27599</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of North Carolina, Chapel Hill</wicri:cityArea>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2012">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Analysis of Variance</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Severity of Illness Index</term>
<term>Substantia Nigra (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Analysis of Variance</term>
<term>Diffusion Magnetic Resonance Imaging</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The pattern of dopamine cell loss in Parkinson's disease is known to be prominent in the ventrolateral and caudal substantia nigra, but less severe in the dorsal and rostral region. Both diffusion tensor imaging and R2* relaxometry of the substantia nigra have been reported as potential markers for Parkinson's disease, but their relative ability to mark disease progression and differences in pathophysiological bases remains unclear.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">High resolution T2-weigthed, R2*, and diffusion tensor imaging were obtained from 28 controls and 40 Parkinson's disease subjects [15 early-stage (disease duration≤1 year), 14 mid-stage (duration 2-5 years), and 11 late-stage (duration>5 years)]. Fractional anisotropy and R2* values in both rostral and caudal substantia nigra were obtained for all subjects, and clinical measures (disease duration; levodopa-equivalent daily dosage; “off”-drug Unified Parkinson's Disease Rating Scale motor score) were obtained for Parkinson's subjects.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There was no correlation between fractional anisotropy and clinical measures, whereas R2* was strongly associated with disease progression. Compared to controls, fractional anisotropy in caudal substantia nigra was significantly decreased in Parkinson's disease patients of all stages, whereas in rostral substantia nigra it was decreased significantly only in the late-stage group. R2* in both substantia nigra regions was significantly increased in the mid-stage and late-stage, but not early-stage, of Parkinson's disease subjects.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">These findings suggest that fractional anisotropy changes may mark early pathological changes in caudal substantia nigra, whereas the changes in R2* may more closely track Parkinson's disease's clinical progression after symptom onset.</p>
</sec>
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