Antiparkinsonian activity of single oral dose of PHNO
Identifieur interne : 003991 ( Istex/Curation ); précédent : 003990; suivant : 003992Antiparkinsonian activity of single oral dose of PHNO
Auteurs : F. Grandas ; N. Quinn ; P. Critchley ; A. Rohan ; Marsden ; S. M. StahlSource :
- Movement Disorders [ 0885-3185 ] ; 1987.
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Abstract
PHNO, a new D‐2 agonist, was investigated in five patients with Parkinson's disease. In an acute, open, oral, dose‐ranging study comparing benefit from single doses, 4 mg of PHNO was found to be equivalent to one tablet of Sinemet 25/250 mg. Adverse reactions were those anticipated for a dopaminomimetic agent. Because of its novel structure and apparent transcutaneous penetration, further studies on PHNO are desirable.
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DOI: 10.1002/mds.870020106
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F. Grandas<affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation>Le document en format XML
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Critchley</name><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation></author><author><name sortKey="Rohan, A" sort="Rohan, A" uniqKey="Rohan A" first="A." last="Rohan">A. Rohan</name><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation></author><author><name sortKey="Stahl, S M" sort="Stahl, S M" uniqKey="Stahl S" first="S. M." last="Stahl">S. M. Stahl</name><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B9AEA15AD5CA96D1A36FD9BFA4604F1E037849DD</idno><date when="1987" year="1987">1987</date><idno type="doi">10.1002/mds.870020106</idno><idno type="url">https://api.istex.fr/document/B9AEA15AD5CA96D1A36FD9BFA4604F1E037849DD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003991</idno><idno type="wicri:Area/Istex/Curation">003991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Antiparkinsonian activity of single oral dose of PHNO</title><author><name sortKey="Grandas, F" sort="Grandas, F" uniqKey="Grandas F" first="F." last="Grandas">F. Grandas</name><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation></author><author><name sortKey="Quinn, N" sort="Quinn, N" uniqKey="Quinn N" first="N." last="Quinn">N. Quinn</name><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation></author><author><name sortKey="Critchley, P" sort="Critchley, P" uniqKey="Critchley P" first="P." last="Critchley">P. 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Rohan</name><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation><mods:affiliation>University Department of Neurology, King's College Hospital Medical School and Institute of Psychiatry, London UK</mods:affiliation><wicri:noCountry code="subField">London UK</wicri:noCountry></affiliation></author><author><name sortKey="Stahl, S M" sort="Stahl, S M" uniqKey="Stahl S" first="S. M." last="Stahl">S. M. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1987">1987</date><biblScope unit="vol">2</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="47">47</biblScope><biblScope unit="page" to="51">51</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B9AEA15AD5CA96D1A36FD9BFA4604F1E037849DD</idno><idno type="DOI">10.1002/mds.870020106</idno><idno type="ArticleID">MDS870020106</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PHNO</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">PHNO, a new D‐2 agonist, was investigated in five patients with Parkinson's disease. In an acute, open, oral, dose‐ranging study comparing benefit from single doses, 4 mg of PHNO was found to be equivalent to one tablet of Sinemet 25/250 mg. Adverse reactions were those anticipated for a dopaminomimetic agent. Because of its novel structure and apparent transcutaneous penetration, further studies on PHNO are desirable.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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