Function of dopamine receptors in young‐onset parkinson's disease: Prolactin response
Identifieur interne : 003377 ( Istex/Curation ); précédent : 003376; suivant : 003378Function of dopamine receptors in young‐onset parkinson's disease: Prolactin response
Auteurs : Kostic [Serbie] ; Zorica Marinkovic [Serbie] ; Sasa Filipovic [Serbie] ; Dragana Momcilovic [Serbie]Source :
- Movement Disorders [ 0885-3185 ] ; 1993.
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Abstract
The basal levels of prolactin (PRL) and their changes after i. v. thyrotropin releasing hormone (TRH) administration after bromocriptine (BCT) pretreatment (BCT/TRH test) were monitored in 12 patients with young‐onset Parkinson's disease (PD) (before 40 years of age) and 10 patients with older‐onset PD (after 40 years of age), as well as in two groups of healthy subjects (10 persons in each), age‐matched with older‐onset (control A) and young‐onset (controlB) parkinsonians. The basal PRL levels were normal in both groups of patients. When given after BCT, TRH induced a significantly lower PRL increase in older‐onset parkinsonians than in controls. This response was even more blunted in young‐onset patients, being significantly more attenuated than in older‐onset PD patients.
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DOI: 10.1002/mds.870080223
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993">1993</date><biblScope unit="vol">8</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="227">227</biblScope><biblScope unit="page" to="229">229</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BAB0B375305AD9F0F67463C60D0474B492B83F20</idno><idno type="DOI">10.1002/mds.870080223</idno><idno type="ArticleID">MDS870080223</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Prolactin</term><term>Young‐onset Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The basal levels of prolactin (PRL) and their changes after i. v. thyrotropin releasing hormone (TRH) administration after bromocriptine (BCT) pretreatment (BCT/TRH test) were monitored in 12 patients with young‐onset Parkinson's disease (PD) (before 40 years of age) and 10 patients with older‐onset PD (after 40 years of age), as well as in two groups of healthy subjects (10 persons in each), age‐matched with older‐onset (control A) and young‐onset (controlB) parkinsonians. The basal PRL levels were normal in both groups of patients. When given after BCT, TRH induced a significantly lower PRL increase in older‐onset parkinsonians than in controls. This response was even more blunted in young‐onset patients, being significantly more attenuated than in older‐onset PD patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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