Alterations of striatal neurons in benign hereditary chorea
Identifieur interne : 003126 ( Istex/Curation ); précédent : 003125; suivant : 003127Alterations of striatal neurons in benign hereditary chorea
Auteurs : Galit Kleiner-Fisman [États-Unis] ; Noel Y. Calingasan [États-Unis] ; Mary Putt [États-Unis] ; June Chen [États-Unis] ; M. Flint Beal [États-Unis] ; Anthony E. Lang [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-10.
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Abstract
Benign hereditary chorea (BHC) recently has been associated with mutations in TITF‐1 gene, although a pathological study of an individual with BHC and a TITF‐1 mutation revealed no significant gross or microscopic abnormalities using standard methods. Immunohistochemical staining of striatal tissue from a BHC‐affected postmortem brain was performed using antibodies against neurotransmitters of interneurons whose tangential migration is mediated by TITF‐1. There was a loss of most TITF‐1–mediated striatal interneurons in the BHC specimen compared to four matched control brains. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20577
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-10">2005-10</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1353">1353</biblScope><biblScope unit="page" to="1357">1357</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">93B807CB7E16134EA05B9026D8B2B230655481A7</idno><idno type="DOI">10.1002/mds.20577</idno><idno type="ArticleID">MDS20577</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>TITF‐1</term><term>benign hereditary chorea</term><term>migration</term><term>pathology</term><term>projection neurons</term><term>striatal interneurons</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Benign hereditary chorea (BHC) recently has been associated with mutations in TITF‐1 gene, although a pathological study of an individual with BHC and a TITF‐1 mutation revealed no significant gross or microscopic abnormalities using standard methods. Immunohistochemical staining of striatal tissue from a BHC‐affected postmortem brain was performed using antibodies against neurotransmitters of interneurons whose tangential migration is mediated by TITF‐1. There was a loss of most TITF‐1–mediated striatal interneurons in the BHC specimen compared to four matched control brains. © 2005 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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