A controlled trial of remacemide hydrochloride in Huntington's disease
Identifieur interne : 002F54 ( Istex/Curation ); précédent : 002F53; suivant : 002F55A controlled trial of remacemide hydrochloride in Huntington's disease
Auteurs : Kieburtz [États-Unis] ; Andrew Feigin [États-Unis] ; Michael Mcdermott [États-Unis] ; Peter Como [États-Unis] ; David Abwender [États-Unis] ; Carol Zimmerman [États-Unis] ; Charlyne Hickey [États-Unis] ; Constance Orme [États-Unis] ; Kathy Claude [États-Unis] ; Jennie Sotack [États-Unis] ; J. Timothy Greenamyre [États-Unis] ; Cynthia Dunn [États-Unis] ; Ira Shoulson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-05.
English descriptors
Abstract
We conducted a randomized, double‐blind, placebo‐controlled tolerability study of a N‐methyl‐D‐aspartate (NMDA) glutamate receptor ion‐channel blocker, remacemide hydrochloride, in 31 independently ambulatory patients (18 men, 13 women) with Huntington's disease (HD). Subjects were randomized to receive either placebo or active remacemide at dosages of 200 mg/day or 600 mg/day. The primary outcome measure was the proportion of subjects able to compleate the study with the assigned treatment. Remacemide was generally well tolerated, and no significant differences between the treatment arms were found in the primary outcome measure. A trend toward impovement in chorea was observed among subjects administered remacemide 200 mg/day. Based on the tolerability and safety demonstrated during this short‐trem trial, remacemide warrants more extended controlled investigation in patients with HD.
Url:
DOI: 10.1002/mds.870110310
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002F54
Links to Exploration step
ISTEX:7D61E5BF3D4506BB687D09C22412B15C5159C9E0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A controlled trial of remacemide hydrochloride in Huntington's disease</title><author><name sortKey="Kieburtz" sort="Kieburtz" uniqKey="Kieburtz" last="Kieburtz">Kieburtz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Mcdermott, Michael" sort="Mcdermott, Michael" uniqKey="Mcdermott M" first="Michael" last="Mcdermott">Michael Mcdermott</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Como, Peter" sort="Como, Peter" uniqKey="Como P" first="Peter" last="Como">Peter Como</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Abwender, David" sort="Abwender, David" uniqKey="Abwender D" first="David" last="Abwender">David Abwender</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Zimmerman, Carol" sort="Zimmerman, Carol" uniqKey="Zimmerman C" first="Carol" last="Zimmerman">Carol Zimmerman</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Hickey, Charlyne" sort="Hickey, Charlyne" uniqKey="Hickey C" first="Charlyne" last="Hickey">Charlyne Hickey</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Orme, Constance" sort="Orme, Constance" uniqKey="Orme C" first="Constance" last="Orme">Constance Orme</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Claude, Kathy" sort="Claude, Kathy" uniqKey="Claude K" first="Kathy" last="Claude">Kathy Claude</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Sotack, Jennie" sort="Sotack, Jennie" uniqKey="Sotack J" first="Jennie" last="Sotack">Jennie Sotack</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Greenamyre, J Timothy" sort="Greenamyre, J Timothy" uniqKey="Greenamyre J" first="J. Timothy" last="Greenamyre">J. Timothy Greenamyre</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Dunn, Cynthia" sort="Dunn, Cynthia" uniqKey="Dunn C" first="Cynthia" last="Dunn">Cynthia Dunn</name><affiliation wicri:level="1"><mods:affiliation>Fisons Pharmaceuticals, Inc., Rochester, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fisons Pharmaceuticals, Inc., Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7D61E5BF3D4506BB687D09C22412B15C5159C9E0</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1002/mds.870110310</idno><idno type="url">https://api.istex.fr/document/7D61E5BF3D4506BB687D09C22412B15C5159C9E0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002F54</idno><idno type="wicri:Area/Istex/Curation">002F54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A controlled trial of remacemide hydrochloride in Huntington's disease</title><author><name sortKey="Kieburtz" sort="Kieburtz" uniqKey="Kieburtz" last="Kieburtz">Kieburtz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Mcdermott, Michael" sort="Mcdermott, Michael" uniqKey="Mcdermott M" first="Michael" last="Mcdermott">Michael Mcdermott</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Como, Peter" sort="Como, Peter" uniqKey="Como P" first="Peter" last="Como">Peter Como</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Abwender, David" sort="Abwender, David" uniqKey="Abwender D" first="David" last="Abwender">David Abwender</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Zimmerman, Carol" sort="Zimmerman, Carol" uniqKey="Zimmerman C" first="Carol" last="Zimmerman">Carol Zimmerman</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Hickey, Charlyne" sort="Hickey, Charlyne" uniqKey="Hickey C" first="Charlyne" last="Hickey">Charlyne Hickey</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Orme, Constance" sort="Orme, Constance" uniqKey="Orme C" first="Constance" last="Orme">Constance Orme</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Claude, Kathy" sort="Claude, Kathy" uniqKey="Claude K" first="Kathy" last="Claude">Kathy Claude</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Sotack, Jennie" sort="Sotack, Jennie" uniqKey="Sotack J" first="Jennie" last="Sotack">Jennie Sotack</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Greenamyre, J Timothy" sort="Greenamyre, J Timothy" uniqKey="Greenamyre J" first="J. Timothy" last="Greenamyre">J. Timothy Greenamyre</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author><author><name sortKey="Dunn, Cynthia" sort="Dunn, Cynthia" uniqKey="Dunn C" first="Cynthia" last="Dunn">Cynthia Dunn</name><affiliation wicri:level="1"><mods:affiliation>Fisons Pharmaceuticals, Inc., Rochester, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fisons Pharmaceuticals, Inc., Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Biostatistics, University of Rochester Medical Center, New York</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1996-05">1996-05</date><biblScope unit="vol">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="273">273</biblScope><biblScope unit="page" to="277">277</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7D61E5BF3D4506BB687D09C22412B15C5159C9E0</idno><idno type="DOI">10.1002/mds.870110310</idno><idno type="ArticleID">MDS870110310</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical trial</term><term>Glutamate‐receptor blocker</term><term>Huntington's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a randomized, double‐blind, placebo‐controlled tolerability study of a N‐methyl‐D‐aspartate (NMDA) glutamate receptor ion‐channel blocker, remacemide hydrochloride, in 31 independently ambulatory patients (18 men, 13 women) with Huntington's disease (HD). Subjects were randomized to receive either placebo or active remacemide at dosages of 200 mg/day or 600 mg/day. The primary outcome measure was the proportion of subjects able to compleate the study with the assigned treatment. Remacemide was generally well tolerated, and no significant differences between the treatment arms were found in the primary outcome measure. A trend toward impovement in chorea was observed among subjects administered remacemide 200 mg/day. Based on the tolerability and safety demonstrated during this short‐trem trial, remacemide warrants more extended controlled investigation in patients with HD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F54 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 002F54 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:7D61E5BF3D4506BB687D09C22412B15C5159C9E0
|texte= A controlled trial of remacemide hydrochloride in Huntington's disease
}}
| This area was generated with Dilib version V0.6.23. |  |