The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo‐controlled pilot study
Identifieur interne : 002F24 ( Istex/Curation ); précédent : 002F23; suivant : 002F25The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo‐controlled pilot study
Auteurs : Tanya Gurevich [Israël] ; Chava Peretz [Israël] ; Orna Moore [Israël] ; Nina Weizmann [Israël] ; Nir Giladi [Israël]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-30.
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Abstract
Objective: To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX‐A) injections in advanced Parkinson's disease (PD) patients. Method: BTX‐A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6‐month follow‐up). Results: Eleven age‐ and disease severity‐matched PD patients with disabling FOG participated. Six patients received BTX‐A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination. Conclusion: BTX‐A injections to the legs did not improve FOG and might increase fall risk. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21396
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Method: BTX‐A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6‐month follow‐up). Results: Eleven age‐ and disease severity‐matched PD patients with disabling FOG participated. Six patients received BTX‐A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination. Conclusion: BTX‐A injections to the legs did not improve FOG and might increase fall risk. © 2007 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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