Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
Identifieur interne : 002F04 ( Istex/Curation ); précédent : 002F03; suivant : 002F05Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
Auteurs : Satoshi Orimo [Japon] ; Takeshi Amino [Japon] ; Masayuki Yokochi [Japon] ; Tohru Kojo [Japon] ; Toshiki Uchihara [Japon] ; Atsushi Takahashi [Japon] ; Koichi Wakabayashi [Japon] ; Hitoshi Takahashi [Japon] ; Nobutaka Hattori [Japon] ; Yoshikuni Mizuno [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-10.
English descriptors
- KwdEn :
Abstract
We performed [123I] MIBG myocardial scintigraphy in two of three patients with PARK2 from unrelated families and examined the heart tissues from the three patients immunohistochemically using an antibody against tyrosine hydroxylase (TH) to see whether cardiac sympathetic nerve is involved. Cardiac uptake of MIBG was normal except for a slight decrease in the late phase in one of the patients. Postmortem examination revealed that TH‐immunoreactive nerve fibers in the epicardium were well preserved in all three patients. The present study confirmed that cardiac sympathetic nerve is well preserved in PARK2 with a homozygous exon deletion, which accounts for normal cardiac uptake of MIBG. Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa‐responsive Parkinsonism, as in PARK2. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20594
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002F04
Links to Exploration step
ISTEX:93A1F555EE9922B77F75A14F22D7C2A6EE6E1916Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2</title><author><name sortKey="Orimo, Satoshi" sort="Orimo, Satoshi" uniqKey="Orimo S" first="Satoshi" last="Orimo">Satoshi Orimo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Kanto Central Hospital, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kanto Central Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Amino, Takeshi" sort="Amino, Takeshi" uniqKey="Amino T" first="Takeshi" last="Amino">Takeshi Amino</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Kanto Central Hospital, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kanto Central Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yokochi, Masayuki" sort="Yokochi, Masayuki" uniqKey="Yokochi M" first="Masayuki" last="Yokochi">Masayuki Yokochi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Ebara Metropolitan Hospital, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Ebara Metropolitan Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kojo, Tohru" sort="Kojo, Tohru" uniqKey="Kojo T" first="Tohru" last="Kojo">Tohru Kojo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Uchihara, Toshiki" sort="Uchihara, Toshiki" uniqKey="Uchihara T" first="Toshiki" last="Uchihara">Toshiki Uchihara</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="1"><mods:affiliation>Organ and Function Pathology Division, Yokufukai Geriatric Hospital, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Organ and Function Pathology Division, Yokufukai Geriatric Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Wakabayashi, Koichi" sort="Wakabayashi, Koichi" uniqKey="Wakabayashi K" first="Koichi" last="Wakabayashi">Koichi Wakabayashi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuropathology, Hirosaki University School of Medicine, Hirosaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Brain Research Institute, University of Niigata, Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:93A1F555EE9922B77F75A14F22D7C2A6EE6E1916</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20594</idno><idno type="url">https://api.istex.fr/document/93A1F555EE9922B77F75A14F22D7C2A6EE6E1916/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002F04</idno><idno type="wicri:Area/Istex/Curation">002F04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2</title><author><name sortKey="Orimo, Satoshi" sort="Orimo, Satoshi" uniqKey="Orimo S" first="Satoshi" last="Orimo">Satoshi Orimo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Kanto Central Hospital, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kanto Central Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Amino, Takeshi" sort="Amino, Takeshi" uniqKey="Amino T" first="Takeshi" last="Amino">Takeshi Amino</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Kanto Central Hospital, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Kanto Central Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yokochi, Masayuki" sort="Yokochi, Masayuki" uniqKey="Yokochi M" first="Masayuki" last="Yokochi">Masayuki Yokochi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Ebara Metropolitan Hospital, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Ebara Metropolitan Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kojo, Tohru" sort="Kojo, Tohru" uniqKey="Kojo T" first="Tohru" last="Kojo">Tohru Kojo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Uchihara, Toshiki" sort="Uchihara, Toshiki" uniqKey="Uchihara T" first="Toshiki" last="Uchihara">Toshiki Uchihara</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="1"><mods:affiliation>Organ and Function Pathology Division, Yokufukai Geriatric Hospital, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Organ and Function Pathology Division, Yokufukai Geriatric Hospital, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Wakabayashi, Koichi" sort="Wakabayashi, Koichi" uniqKey="Wakabayashi K" first="Koichi" last="Wakabayashi">Koichi Wakabayashi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuropathology, Hirosaki University School of Medicine, Hirosaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Brain Research Institute, University of Niigata, Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine, Tokyo</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-10">2005-10</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1350">1350</biblScope><biblScope unit="page" to="1353">1353</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">93A1F555EE9922B77F75A14F22D7C2A6EE6E1916</idno><idno type="DOI">10.1002/mds.20594</idno><idno type="ArticleID">MDS20594</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MIBG myocardial scintigraphy</term><term>PARK2</term><term>Parkinson's disease</term><term>cardiac sympathetic nerve</term><term>denervation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed [123I] MIBG myocardial scintigraphy in two of three patients with PARK2 from unrelated families and examined the heart tissues from the three patients immunohistochemically using an antibody against tyrosine hydroxylase (TH) to see whether cardiac sympathetic nerve is involved. Cardiac uptake of MIBG was normal except for a slight decrease in the late phase in one of the patients. Postmortem examination revealed that TH‐immunoreactive nerve fibers in the epicardium were well preserved in all three patients. The present study confirmed that cardiac sympathetic nerve is well preserved in PARK2 with a homozygous exon deletion, which accounts for normal cardiac uptake of MIBG. Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa‐responsive Parkinsonism, as in PARK2. © 2005 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F04 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 002F04 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:93A1F555EE9922B77F75A14F22D7C2A6EE6E1916
|texte= Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
}}
| This area was generated with Dilib version V0.6.23. |  |