Skin cancers and precancerous lesions in Parkinson's disease patients
Identifieur interne : 002A41 ( Istex/Curation ); précédent : 002A40; suivant : 002A42Skin cancers and precancerous lesions in Parkinson's disease patients
Auteurs : Joaquim Ferreira [Portugal] ; João Maia Silva [Portugal] ; Rita Freire [Portugal] ; João Pignatelli [Portugal] ; Leonor Correia Guedes [Portugal] ; Alexandra Feij [Portugal] ; Mário Miguel Rosa [Portugal] ; Miguel Coelho [Portugal] ; João Costa [Portugal] ; Ana Noronha [Portugal] ; Russell Hewett [Portugal] ; A. Marques Gomes [Portugal] ; J. L. Cirne De Castro [Portugal] ; Olivier Rascol [France] ; Cristina Sampaio [Portugal]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-30.
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Abstract
Our objective was to evaluate the frequency of neoplastic and preneoplastic skin lesions in Parkinson's disease (PD) patients when compared with an aged‐matched population. We performed a cross‐sectional survey in PD patients and in an age‐matched control group. Patients and controls were examined by a movement disorder specialist and a dermatologist. 150 PD patients and 146 controls were included. Thirty‐five PD patients (23.3%) presented skin lesions that could be classified as neoplastic or preneoplastic vs. 20 subjects in the control group (13.7%) (OR 95%, CI 1.92 [1.05, 3.51]). However, this difference lost statistical significance when adjusted for gender (recruitment of controls was matched just for age with an over representation of males in the PD group). Twenty‐nine PD patients (19%) presented actinic keratosis and basal cell carcinoma was diagnosed in 4 patients (3%). Although nonconclusive, our results are in agreement with previous studies suggesting an increased risk of skin cancer in PD patients. The frequency of actinic keratosis in PD patients and the associated risk to develop melanoma recommends its screening in future epidemiological studies. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21575
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Marques" last="Gomes">A. Marques Gomes</name><affiliation wicri:level="1"><mods:affiliation>Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Dermatology Department, Hospital de Santa Maria, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="De Castro, J L Cirne" sort="De Castro, J L Cirne" uniqKey="De Castro J" first="J. L. Cirne" last="De Castro">J. L. 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Joaquim" sort="Ferreira, Joaquim" uniqKey="Ferreira J" first="Joaquim" last="Ferreira">Joaquim Ferreira</name><affiliation wicri:level="1"><mods:affiliation>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Silva, Joao Maia" sort="Silva, Joao Maia" uniqKey="Silva J" first="João Maia" last="Silva">João Maia Silva</name><affiliation wicri:level="1"><mods:affiliation>Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Dermatology Department, Hospital de Santa Maria, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Freire, Rita" sort="Freire, Rita" uniqKey="Freire R" first="Rita" 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Guedes</name><affiliation wicri:level="1"><mods:affiliation>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Feij, Alexandra" sort="Feij, Alexandra" uniqKey="Feij A" first="Alexandra" last="Feij">Alexandra Feij</name><affiliation wicri:level="1"><mods:affiliation>Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Dermatology Department, Hospital de Santa Maria, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Rosa, Mario Miguel" sort="Rosa, Mario Miguel" uniqKey="Rosa M" first="Mário Miguel" last="Rosa">Mário Miguel Rosa</name><affiliation wicri:level="1"><mods:affiliation>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Coelho, Miguel" sort="Coelho, Miguel" uniqKey="Coelho M" first="Miguel" last="Coelho">Miguel Coelho</name><affiliation wicri:level="1"><mods:affiliation>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Costa, Joao" sort="Costa, Joao" uniqKey="Costa J" first="João" last="Costa">João Costa</name><affiliation wicri:level="1"><mods:affiliation>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Noronha, Ana" sort="Noronha, Ana" uniqKey="Noronha A" first="Ana" last="Noronha">Ana Noronha</name><affiliation wicri:level="1"><mods:affiliation>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Hewett, Russell" sort="Hewett, Russell" uniqKey="Hewett R" first="Russell" last="Hewett">Russell Hewett</name><affiliation wicri:level="1"><mods:affiliation>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Gomes, A Marques" sort="Gomes, A Marques" uniqKey="Gomes A" first="A. Marques" last="Gomes">A. Marques Gomes</name><affiliation wicri:level="1"><mods:affiliation>Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Dermatology Department, Hospital de Santa Maria, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="De Castro, J L Cirne" sort="De Castro, J L Cirne" uniqKey="De Castro J" first="J. L. Cirne" last="De Castro">J. L. Cirne De Castro</name><affiliation wicri:level="1"><mods:affiliation>Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Dermatology Department, Hospital de Santa Maria, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><mods:affiliation>Clinical Investigation Centre, Department of Clinical Pharmacology and Neurosciences, University Hospital, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Clinical Investigation Centre, Department of Clinical Pharmacology and Neurosciences, University Hospital, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name><affiliation wicri:level="1"><mods:affiliation>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Neurological Clinic Research Unit, Institute of Molecular Medicine, Lisbon School of Medicine, Lisbon</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-30">2007-07-30</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1471">1471</biblScope><biblScope unit="page" to="1475">1475</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">51643B36B6A3E14FBC303C7EA84C9BC9F9DBC7A3</idno><idno type="DOI">10.1002/mds.21575</idno><idno type="ArticleID">MDS21575</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>actinic keratosis</term><term>melanoma</term><term>skin cancer</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our objective was to evaluate the frequency of neoplastic and preneoplastic skin lesions in Parkinson's disease (PD) patients when compared with an aged‐matched population. We performed a cross‐sectional survey in PD patients and in an age‐matched control group. Patients and controls were examined by a movement disorder specialist and a dermatologist. 150 PD patients and 146 controls were included. Thirty‐five PD patients (23.3%) presented skin lesions that could be classified as neoplastic or preneoplastic vs. 20 subjects in the control group (13.7%) (OR 95%, CI 1.92 [1.05, 3.51]). However, this difference lost statistical significance when adjusted for gender (recruitment of controls was matched just for age with an over representation of males in the PD group). Twenty‐nine PD patients (19%) presented actinic keratosis and basal cell carcinoma was diagnosed in 4 patients (3%). Although nonconclusive, our results are in agreement with previous studies suggesting an increased risk of skin cancer in PD patients. The frequency of actinic keratosis in PD patients and the associated risk to develop melanoma recommends its screening in future epidemiological studies. © 2007 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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