Positron emission tomographic studies in restless legs syndrome
Identifieur interne : 002A30 ( Istex/Curation ); précédent : 002A29; suivant : 002A31Positron emission tomographic studies in restless legs syndrome
Auteurs : Claudia Trenkwalder [Allemagne] ; Arthur S. Walters [États-Unis] ; Wayne A. Hening [États-Unis] ; Sudhansu Chokroverty [États-Unis] ; Angelo Antonini [États-Unis] ; Vijay Dhawan [États-Unis] ; David Eidelberg [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1999-01.
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Abstract
We studied six restless legs syndrome (RLS) patients with [F18]fluorodeoxyglucose (FDG) positron emission tomography (PET). We also studied four of these same patients with [F18]fluorodopa (FDOPA) PET. The patients' FDG and FDOPA PET scans were compared with those from age‐matched healthy control subjects. No significant differences between the two groups were found for any regional blood flow values derived from the FDG scans or for any binding constants derived from the FDOPA scans. These results suggest that any abnormal resting brain metabolic activity or putative presynaptic dopaminergic defect in RLS is likely either to be so subtle that it is below the threshold for ready detection by PET or that it is located in an area of neural tissue inaccessible to the current scanner. No substantial defect is likely to involve the dopaminergic nigrostriatal axis.
Url:
DOI: 10.1002/1531-8257(199901)14:1<141::AID-MDS1024>3.0.CO;2-B
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-01">1999-01</date><biblScope unit="vol">14</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="141">141</biblScope><biblScope unit="page" to="145">145</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">40F9C1EEE3E5C17FE336545F551138275DB655AB</idno><idno type="DOI">10.1002/1531-8257(199901)14:1<141::AID-MDS1024>3.0.CO;2-B</idno><idno type="ArticleID">MDS1024</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fluorodeoxyglucose</term><term>Fluorodopa</term><term>Periodic limb movements (PLM)</term><term>Positron emission tomography (PET)</term><term>Restless legs syndrome (RLS)</term><term>Sleep disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied six restless legs syndrome (RLS) patients with [F18]fluorodeoxyglucose (FDG) positron emission tomography (PET). We also studied four of these same patients with [F18]fluorodopa (FDOPA) PET. The patients' FDG and FDOPA PET scans were compared with those from age‐matched healthy control subjects. No significant differences between the two groups were found for any regional blood flow values derived from the FDG scans or for any binding constants derived from the FDOPA scans. These results suggest that any abnormal resting brain metabolic activity or putative presynaptic dopaminergic defect in RLS is likely either to be so subtle that it is below the threshold for ready detection by PET or that it is located in an area of neural tissue inaccessible to the current scanner. No substantial defect is likely to involve the dopaminergic nigrostriatal axis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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