Staging of α‐synuclein in the olfactory bulb in a model of Parkinson's disease: Cell types involved
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Auteurs : Isabel Ubeda-Ba On [Espagne] ; Daniel Saiz-Sanchez [Espagne] ; Carlos De La Rosa-Prieto [Espagne] ; Alicia Mohedano-Moriano [Espagne] ; Noelia Fradejas [Espagne] ; Soledad Calvo [Espagne] ; Lucia Argando A-Palacios [Espagne] ; Susana Garcia-Mu Ozguren [Espagne] ; Alino Martinez-Marcos [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-08-15.
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Abstract
Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes α‐synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by α‐synuclein in the olfactory bulb of transgenic mice (2–8 months of age) expressing the human A53T variant of α‐synuclein. α‐Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic‐ and calcium binding protein‐positive cells are severely affected. This temporal evolution and the cell types expressing α‐synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23197
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Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-08-15">2010-08-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1701">1701</biblScope><biblScope unit="page" to="1707">1707</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">10359730CEADE4DE890FEF03D1FB7ECEC2342E1A</idno><idno type="DOI">10.1002/mds.23197</idno><idno type="ArticleID">MDS23197</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>calcium binding protein</term><term>olfactory bulb</term><term>olfactory deficit</term><term>transgenic mice</term><term>tyrosine hydroxylase</term><term>α‐Synuclein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes α‐synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by α‐synuclein in the olfactory bulb of transgenic mice (2–8 months of age) expressing the human A53T variant of α‐synuclein. α‐Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic‐ and calcium binding protein‐positive cells are severely affected. This temporal evolution and the cell types expressing α‐synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease. © 2010 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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