Speech disturbances in patients with dystonia or chorea due to neurometabolic disorders
Identifieur interne : 002707 ( Istex/Curation ); précédent : 002706; suivant : 002708Speech disturbances in patients with dystonia or chorea due to neurometabolic disorders
Auteurs : Constance Flamand-Rouvière [France] ; Emilie Guettard [France] ; Caroline Moreau [France] ; Nadia Bahi-Buisson [France] ; Vassili Valayannopoulos [France] ; David Grabli [France] ; Jacques Motte [France] ; Diana Rodriguez [France] ; Agathe Roubertie [France] ; Lisa Maintigneux [France] ; Isabelle Kemlin [France] ; Irène Ceballos-Picot [France] ; David Adams [France] ; Marie Vidailhet [France] ; Emmanuel Roze [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-08-15.
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Abstract
Speech disturbances are frequent and potentially disabling in patients with dystonia or chorea due to neurometabolic disorders (DCND), but their precise characteristics are poorly documented. We prospectively studied 29 consecutive patients with DCND. A detailed description of their speech patterns was obtained by using the Frenchay dysarthria assessment test and the apraxia of speech evaluation test of Wertz. Gross motor function and intelligibility were each scored on 5‐point scales to identify a possible correlation between the severity of the speech and motor disorders. All the patients were found to have complex speech alterations with combined features of hyperkinetic dysarthria and speech apraxia. We also noted a correlation between the severity of the speech disorders and the motor disorders. These findings have important implications for speech rehabilitation, and may provide new insights into the pathophysiology of dystonia due to neurometabolic disorders. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23134
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type="url">https://api.istex.fr/document/719CC78E4AD3224B0B825544C05A30F7A1524790/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002707</idno><idno type="wicri:Area/Istex/Curation">002707</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Speech disturbances in patients with dystonia or chorea due to neurometabolic disorders</title><author><name sortKey="Flamand Ouviere, Constance" sort="Flamand Ouviere, Constance" uniqKey="Flamand Ouviere C" first="Constance" last="Flamand-Rouvière">Constance Flamand-Rouvière</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Bicêtre, AP‐HP, Le Kremlin Bicêtre, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Bicêtre, AP‐HP, Le Kremlin Bicêtre</wicri:regionArea></affiliation></author><author><name sortKey="Guettard, Emilie" sort="Guettard, Emilie" uniqKey="Guettard E" first="Emilie" last="Guettard">Emilie Guettard</name><affiliation wicri:level="1"><mods:affiliation>Service de médecine physique et de réadaptation, Hôpital Fernand Widal, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de médecine physique et de réadaptation, Hôpital Fernand Widal, AP‐HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation wicri:level="1"><mods:affiliation>Service de neurologie et pathologie du mouvement, IMPRT, Lille EA 2683, IFR 114, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neurologie et pathologie du mouvement, IMPRT, Lille EA 2683, IFR 114</wicri:regionArea></affiliation></author><author><name sortKey="Bahi Uisson, Nadia" sort="Bahi Uisson, Nadia" uniqKey="Bahi Uisson N" first="Nadia" last="Bahi-Buisson">Nadia Bahi-Buisson</name><affiliation wicri:level="1"><mods:affiliation>Service Neurologie Pédiatrique et Maladies métaboliques, Hôpital Necker Enfants Malades, Université Paris‐Descartes, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service Neurologie Pédiatrique et Maladies métaboliques, Hôpital Necker Enfants Malades, Université Paris‐Descartes, AP‐HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Commission Mouvements Anormaux, de la Société Française de Neurologie Pédiatrique, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Commission Mouvements Anormaux, de la Société Française de Neurologie Pédiatrique</wicri:regionArea></affiliation></author><author><name sortKey="Valayannopoulos, Vassili" sort="Valayannopoulos, Vassili" uniqKey="Valayannopoulos V" first="Vassili" last="Valayannopoulos">Vassili Valayannopoulos</name><affiliation wicri:level="1"><mods:affiliation>Service Neurologie Pédiatrique et Maladies métaboliques, Hôpital Necker Enfants Malades, Université Paris‐Descartes, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service Neurologie Pédiatrique et Maladies métaboliques, Hôpital Necker Enfants Malades, Université Paris‐Descartes, AP‐HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre de Référence des Maladies Héréditaires du Métabolisme, Hôpital Necker Enfants Malades, Université Paris‐Descartes, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Référence des Maladies Héréditaires du Métabolisme, Hôpital Necker Enfants Malades, Université Paris‐Descartes, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name><affiliation wicri:level="1"><mods:affiliation>Pôle des maladies du système nerveux, Fédération de Neurologie, Groupe Hospitalier Pitié‐Salpêtrière, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pôle des maladies du système nerveux, Fédération de Neurologie, Groupe Hospitalier Pitié‐Salpêtrière, AP‐HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Motte, Jacques" sort="Motte, Jacques" uniqKey="Motte J" first="Jacques" last="Motte">Jacques Motte</name><affiliation wicri:level="1"><mods:affiliation>Unité de neurologie pédiatrique, American Memorial Hospital, CHU Reims, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de neurologie pédiatrique, American Memorial Hospital, CHU Reims</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez, Diana" sort="Rodriguez, Diana" uniqKey="Rodriguez D" first="Diana" last="Rodriguez">Diana Rodriguez</name><affiliation wicri:level="1"><mods:affiliation>Service de neuropédiatrie, Université Pierre et Marie Curie, Paris VI, Hôpital Armand Trousseau, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neuropédiatrie, Université Pierre et Marie Curie, Paris VI, Hôpital Armand Trousseau, AP‐HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Roubertie, Agathe" sort="Roubertie, Agathe" uniqKey="Roubertie A" first="Agathe" last="Roubertie">Agathe Roubertie</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie Pédiatrique, CHU, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie Pédiatrique, CHU, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Maintigneux, Lisa" sort="Maintigneux, Lisa" uniqKey="Maintigneux L" first="Lisa" last="Maintigneux">Lisa Maintigneux</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Bicêtre, AP‐HP, Le Kremlin Bicêtre, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Bicêtre, AP‐HP, Le Kremlin Bicêtre</wicri:regionArea></affiliation></author><author><name sortKey="Kemlin, Isabelle" sort="Kemlin, Isabelle" uniqKey="Kemlin I" first="Isabelle" last="Kemlin">Isabelle Kemlin</name><affiliation wicri:level="1"><mods:affiliation>Service de neuropédiatrie, Université Pierre et Marie Curie, Paris VI, Hôpital Armand Trousseau, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de neuropédiatrie, Université Pierre et Marie Curie, Paris VI, Hôpital Armand Trousseau, AP‐HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Ceballos Icot, Irene" sort="Ceballos Icot, Irene" uniqKey="Ceballos Icot I" first="Irène" last="Ceballos-Picot">Irène Ceballos-Picot</name><affiliation wicri:level="1"><mods:affiliation>Service de Biochimie Métabolique, Hôpital Necker Enfants Malades, Université Paris‐Descartes, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Biochimie Métabolique, Hôpital Necker Enfants Malades, Université Paris‐Descartes, AP‐HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Adams, David" sort="Adams, David" uniqKey="Adams D" first="David" last="Adams">David Adams</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU de Bicêtre, AP‐HP, Le Kremlin Bicêtre, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU de Bicêtre, AP‐HP, Le Kremlin Bicêtre</wicri:regionArea></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation wicri:level="1"><mods:affiliation>Pôle des maladies du système nerveux, Fédération de Neurologie, Groupe Hospitalier Pitié‐Salpêtrière, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pôle des maladies du système nerveux, Fédération de Neurologie, Groupe Hospitalier Pitié‐Salpêtrière, AP‐HP, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name><affiliation wicri:level="1"><mods:affiliation>Commission Mouvements Anormaux, de la Société Française de Neurologie Pédiatrique, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Commission Mouvements Anormaux, de la Société Française de Neurologie Pédiatrique</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Pôle des maladies du système nerveux, Fédération de Neurologie, Groupe Hospitalier Pitié‐Salpêtrière, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pôle des maladies du système nerveux, Fédération de Neurologie, Groupe Hospitalier Pitié‐Salpêtrière, AP‐HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre d'Investigation Clinique, 9503, INSERM, AP‐HP, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Investigation Clinique, 9503, INSERM, AP‐HP, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS UMRS 952, INSERM UMR 7224, Université Pierre et Marie Curie Paris VI, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMRS 952, INSERM UMR 7224, Université Pierre et Marie Curie Paris VI, Paris</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-08-15">2010-08-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1605">1605</biblScope><biblScope unit="page" to="1611">1611</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">719CC78E4AD3224B0B825544C05A30F7A1524790</idno><idno type="DOI">10.1002/mds.23134</idno><idno type="ArticleID">MDS23134</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>GM1 gangliosidosis type 3</term><term>Lesch‐Nyhan disease</term><term>dystonia</term><term>glutaric aciduria type 1</term><term>hyperkinetic dysarthria</term><term>speech apraxia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Speech disturbances are frequent and potentially disabling in patients with dystonia or chorea due to neurometabolic disorders (DCND), but their precise characteristics are poorly documented. We prospectively studied 29 consecutive patients with DCND. A detailed description of their speech patterns was obtained by using the Frenchay dysarthria assessment test and the apraxia of speech evaluation test of Wertz. Gross motor function and intelligibility were each scored on 5‐point scales to identify a possible correlation between the severity of the speech and motor disorders. All the patients were found to have complex speech alterations with combined features of hyperkinetic dysarthria and speech apraxia. We also noted a correlation between the severity of the speech disorders and the motor disorders. These findings have important implications for speech rehabilitation, and may provide new insights into the pathophysiology of dystonia due to neurometabolic disorders. © 2010 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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