Reliability and validity of the International Cooperative Ataxia Rating Scale: A study in 156 spinocerebellar ataxia patients
Identifieur interne : 001F64 ( Istex/Curation ); précédent : 001F63; suivant : 001F65Reliability and validity of the International Cooperative Ataxia Rating Scale: A study in 156 spinocerebellar ataxia patients
Auteurs : Tanja Schmitz-Hübsch [Allemagne] ; Sophie Tezenas Du Montcel [France] ; Laszlo Baliko [Hongrie] ; Sylvia Boesch [Autriche] ; Sara Bonato [Belgique] ; Roberto Fancellu [Italie] ; Paola Giunti [Royaume-Uni] ; Christoph Globas [Allemagne] ; Jun-Suk Kang [Allemagne] ; Berry Kremer [Pays-Bas] ; Caterina Mariotti [Italie] ; Bela Melegh [Hongrie] ; Maryla Rakowicz [Pologne] ; Rafal Rola [Pologne] ; Sylvie Romano [Italie] ; Lodger Schöls [Allemagne] ; Sandra Szymanski [Allemagne] ; Bart P. C. Van De Warrenburg [Pays-Bas] ; Elzbieta Zdzienicka [Pologne] ; Alexandra Dürr [France] ; Thomas Klockgether [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-05.
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Abstract
To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test–retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20781
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Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Globas, Christoph" sort="Globas, Christoph" uniqKey="Globas C" first="Christoph" last="Globas">Christoph Globas</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jun Uk" sort="Kang, Jun Uk" uniqKey="Kang J" first="Jun-Suk" last="Kang">Jun-Suk Kang</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Frankfurt, Frankfurt, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Frankfurt, Frankfurt</wicri:regionArea></affiliation></author><author><name sortKey="Kremer, Berry" sort="Kremer, Berry" uniqKey="Kremer B" first="Berry" last="Kremer">Berry Kremer</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Bela" last="Melegh">Bela Melegh</name><affiliation wicri:level="1"><mods:affiliation>Department of Genetics, University of Pecs, Pecs, Hungary</mods:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Genetics, University of Pecs, Pecs</wicri:regionArea></affiliation></author><author><name sortKey="Rakowicz, Maryla" sort="Rakowicz, Maryla" uniqKey="Rakowicz M" first="Maryla" last="Rakowicz">Maryla Rakowicz</name><affiliation wicri:level="1"><mods:affiliation>Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Rola, Rafal" sort="Rola, Rafal" uniqKey="Rola R" first="Rafal" last="Rola">Rafal Rola</name><affiliation wicri:level="1"><mods:affiliation>Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Romano, Sylvie" sort="Romano, Sylvie" uniqKey="Romano S" first="Sylvie" last="Romano">Sylvie Romano</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Schols, Lodger" sort="Schols, Lodger" uniqKey="Schols L" first="Lodger" last="Schöls">Lodger Schöls</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Szymanski, Sandra" sort="Szymanski, Sandra" uniqKey="Szymanski S" first="Sandra" last="Szymanski">Sandra Szymanski</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, St. Josef Hospital, University Hospital, Bochum, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, St. Josef Hospital, University Hospital, Bochum</wicri:regionArea></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Zdzienicka, Elzbieta" sort="Zdzienicka, Elzbieta" uniqKey="Zdzienicka E" first="Elzbieta" last="Zdzienicka">Elzbieta Zdzienicka</name><affiliation wicri:level="1"><mods:affiliation>Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation wicri:level="1"><mods:affiliation>INSERM U679 and Department of Genetics, Cytogenetics and Embryology, Hôpital de la Pitié‐Salpêtrière, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U679 and Department of Genetics, Cytogenetics and Embryology, Hôpital de la Pitié‐Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B01E3B54257C906A5647F09B900B565A7870B232</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/mds.20781</idno><idno type="url">https://api.istex.fr/document/B01E3B54257C906A5647F09B900B565A7870B232/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001F64</idno><idno type="wicri:Area/Istex/Curation">001F64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reliability and validity of the International Cooperative Ataxia Rating Scale: A study in 156 spinocerebellar ataxia patients</title><author><name sortKey="Schmitz Bsch, Tanja" sort="Schmitz Bsch, Tanja" uniqKey="Schmitz Bsch T" first="Tanja" last="Schmitz-Hübsch">Tanja Schmitz-Hübsch</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Tezenas Du Montcel, Sophie" sort="Tezenas Du Montcel, Sophie" uniqKey="Tezenas Du Montcel S" first="Sophie" last="Tezenas Du Montcel">Sophie Tezenas Du Montcel</name><affiliation wicri:level="1"><mods:affiliation>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Baliko, Laszlo" sort="Baliko, Laszlo" uniqKey="Baliko L" first="Laszlo" last="Baliko">Laszlo Baliko</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Stroke, County Hospital, Veszprém, Hungary</mods:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Neurology and Stroke, County Hospital, Veszprém</wicri:regionArea></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Bonato, Sara" sort="Bonato, Sara" uniqKey="Bonato S" first="Sara" last="Bonato">Sara Bonato</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hôpital Erasme, University of Brussels, Brussels, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, Hôpital Erasme, University of Brussels, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Fancellu, Roberto" sort="Fancellu, Roberto" uniqKey="Fancellu R" first="Roberto" last="Fancellu">Roberto Fancellu</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Globas, Christoph" sort="Globas, Christoph" uniqKey="Globas C" first="Christoph" last="Globas">Christoph Globas</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jun Uk" sort="Kang, Jun Uk" uniqKey="Kang J" first="Jun-Suk" last="Kang">Jun-Suk Kang</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Frankfurt, Frankfurt, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Frankfurt, Frankfurt</wicri:regionArea></affiliation></author><author><name sortKey="Kremer, Berry" sort="Kremer, Berry" uniqKey="Kremer B" first="Berry" last="Kremer">Berry Kremer</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Bela" last="Melegh">Bela Melegh</name><affiliation wicri:level="1"><mods:affiliation>Department of Genetics, University of Pecs, Pecs, Hungary</mods:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Genetics, University of Pecs, Pecs</wicri:regionArea></affiliation></author><author><name sortKey="Rakowicz, Maryla" sort="Rakowicz, Maryla" uniqKey="Rakowicz M" first="Maryla" last="Rakowicz">Maryla Rakowicz</name><affiliation wicri:level="1"><mods:affiliation>Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Rola, Rafal" sort="Rola, Rafal" uniqKey="Rola R" first="Rafal" last="Rola">Rafal Rola</name><affiliation wicri:level="1"><mods:affiliation>Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Romano, Sylvie" sort="Romano, Sylvie" uniqKey="Romano S" first="Sylvie" last="Romano">Sylvie Romano</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Schols, Lodger" sort="Schols, Lodger" uniqKey="Schols L" first="Lodger" last="Schöls">Lodger Schöls</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Szymanski, Sandra" sort="Szymanski, Sandra" uniqKey="Szymanski S" first="Sandra" last="Szymanski">Sandra Szymanski</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, St. Josef Hospital, University Hospital, Bochum, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, St. Josef Hospital, University Hospital, Bochum</wicri:regionArea></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Zdzienicka, Elzbieta" sort="Zdzienicka, Elzbieta" uniqKey="Zdzienicka E" first="Elzbieta" last="Zdzienicka">Elzbieta Zdzienicka</name><affiliation wicri:level="1"><mods:affiliation>Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation wicri:level="1"><mods:affiliation>INSERM U679 and Department of Genetics, Cytogenetics and Embryology, Hôpital de la Pitié‐Salpêtrière, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U679 and Department of Genetics, Cytogenetics and Embryology, Hôpital de la Pitié‐Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-05">2006-05</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="699">699</biblScope><biblScope unit="page" to="704">704</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B01E3B54257C906A5647F09B900B565A7870B232</idno><idno type="DOI">10.1002/mds.20781</idno><idno type="ArticleID">MDS20781</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ICARS</term><term>clinical assessment</term><term>spinocerebellar ataxia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test–retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials. © 2006 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Reliability and validity of the International Cooperative Ataxia Rating Scale: A study in 156 spinocerebellar ataxia patients
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