Effectiveness of piracetam in cortical myoclonus
Identifieur interne : 001B54 ( Istex/Curation ); précédent : 001B53; suivant : 001B55Effectiveness of piracetam in cortical myoclonus
Auteurs : P. Brown [Royaume-Uni] ; M. J. Steiger [Royaume-Uni] ; P. D. Thompson [Royaume-Uni] ; J. C. Rothwell [Royaume-Uni] ; B. L. Day [Royaume-Uni] ; M. Salama [Belgique] ; T. Waegemans [Belgique] ; Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1993.
English descriptors
- KwdEn :
Abstract
Twenty‐one patients with disabling spontaneous, reflex, or action myoclonus due to various causes, who had shown apparent clinical improvement on introduction of piracetam, entered a placebo‐controlled double‐blind crossover trial of piracetam (2.4– 16.8 g daily). All but one patient had electrophysiological evidence of cortical myoclonus. Patients were randomly allocated to a 14‐ day course of piracetam followed by identical placebo, or placebo followed by piracetam. Nineteen patients received piracetam/placebo in addition to their routine antimyoclonic treatment (carbamazepine, clonazepam, phenytoin, primidone, sodium valproate, or tryptophan plus isocarboxazid, alone or in combination) and two received piracetam/placebo as monotherapy. All patients were rated at the end of each treatment phase using stimulus sensitivity, motor, writing, functional disability, global assessment, and visual analogue scales. Ten of the 21 patients had to be rescued from the placebo phase of the trial because of a severe and intolerable exacerbation of their myoclonus. No patients required rescue from the piracetam phase of the double‐blind trial. When the 21 patients were considered together, there was a significant improvement in motor, writing, functional disability, global assessment, and visual analogue scores during treatment with piracetam compared with placebo. The total rating score also improved significantly with piracetam, by a median of 22%. Piracetam, usually in combination with other antimyoclonic drugs, is a useful treatment for myoclonus of cortical origin.
Url:
DOI: 10.1002/mds.870080112
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001B54
Links to Exploration step
ISTEX:BB6FBD1E67637226BCE673AD93997113E3721EBDLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effectiveness of piracetam in cortical myoclonus</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Steiger, M J" sort="Steiger, M J" uniqKey="Steiger M" first="M. J." last="Steiger">M. J. Steiger</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Salama, M" sort="Salama, M" uniqKey="Salama M" first="M." last="Salama">M. Salama</name><affiliation wicri:level="1"><mods:affiliation>CRC, Brussels, Brainel 'Alleud, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>CRC, Brussels, Brainel 'Alleud</wicri:regionArea></affiliation></author><author><name sortKey="Waegemans, T" sort="Waegemans, T" uniqKey="Waegemans T" first="T." last="Waegemans">T. Waegemans</name><affiliation wicri:level="1"><mods:affiliation>U.C.B. s.a. Pharmaceutical Sector, Brainel 'Alleud, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>U.C.B. s.a. Pharmaceutical Sector, Brainel 'Alleud</wicri:regionArea></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BB6FBD1E67637226BCE673AD93997113E3721EBD</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1002/mds.870080112</idno><idno type="url">https://api.istex.fr/document/BB6FBD1E67637226BCE673AD93997113E3721EBD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B54</idno><idno type="wicri:Area/Istex/Curation">001B54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effectiveness of piracetam in cortical myoclonus</title><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Steiger, M J" sort="Steiger, M J" uniqKey="Steiger M" first="M. J." last="Steiger">M. J. Steiger</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Salama, M" sort="Salama, M" uniqKey="Salama M" first="M." last="Salama">M. Salama</name><affiliation wicri:level="1"><mods:affiliation>CRC, Brussels, Brainel 'Alleud, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>CRC, Brussels, Brainel 'Alleud</wicri:regionArea></affiliation></author><author><name sortKey="Waegemans, T" sort="Waegemans, T" uniqKey="Waegemans T" first="T." last="Waegemans">T. Waegemans</name><affiliation wicri:level="1"><mods:affiliation>U.C.B. s.a. Pharmaceutical Sector, Brainel 'Alleud, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>U.C.B. s.a. Pharmaceutical Sector, Brainel 'Alleud</wicri:regionArea></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit and University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993">1993</date><biblScope unit="vol">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="63">63</biblScope><biblScope unit="page" to="68">68</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BB6FBD1E67637226BCE673AD93997113E3721EBD</idno><idno type="DOI">10.1002/mds.870080112</idno><idno type="ArticleID">MDS870080112</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cortical myoclonus</term><term>Piracetam</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Twenty‐one patients with disabling spontaneous, reflex, or action myoclonus due to various causes, who had shown apparent clinical improvement on introduction of piracetam, entered a placebo‐controlled double‐blind crossover trial of piracetam (2.4– 16.8 g daily). All but one patient had electrophysiological evidence of cortical myoclonus. Patients were randomly allocated to a 14‐ day course of piracetam followed by identical placebo, or placebo followed by piracetam. Nineteen patients received piracetam/placebo in addition to their routine antimyoclonic treatment (carbamazepine, clonazepam, phenytoin, primidone, sodium valproate, or tryptophan plus isocarboxazid, alone or in combination) and two received piracetam/placebo as monotherapy. All patients were rated at the end of each treatment phase using stimulus sensitivity, motor, writing, functional disability, global assessment, and visual analogue scales. Ten of the 21 patients had to be rescued from the placebo phase of the trial because of a severe and intolerable exacerbation of their myoclonus. No patients required rescue from the piracetam phase of the double‐blind trial. When the 21 patients were considered together, there was a significant improvement in motor, writing, functional disability, global assessment, and visual analogue scores during treatment with piracetam compared with placebo. The total rating score also improved significantly with piracetam, by a median of 22%. Piracetam, usually in combination with other antimyoclonic drugs, is a useful treatment for myoclonus of cortical origin.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B54 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001B54 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:BB6FBD1E67637226BCE673AD93997113E3721EBD
|texte= Effectiveness of piracetam in cortical myoclonus
}}
| This area was generated with Dilib version V0.6.23. |  |