The opiate antagonist naloxone suppresses a rodent model of tardive dyskinesia
Identifieur interne : 001868 ( Istex/Curation ); précédent : 001867; suivant : 001869The opiate antagonist naloxone suppresses a rodent model of tardive dyskinesia
Auteurs : Stoessl [Canada] ; Elizabeth Polanski [Canada] ; Hanna Frydryszak [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 1993.
English descriptors
Abstract
The effects of both opiate agonists and the opiate antagonist naloxone were examined in a rodent model of tardive dyskinesia (TD). Chronic (˜20 weeks) administration of fluphenazine resulted in the emergence of vacuous chewing mouth movements (VCMs), a response which may be a useful model for this disorder. Fluphenazine‐induced VCMs were not affected by a variety of selective opiate agonists administered intracerebroventricularly, but were potently suppressed by subcutaneous administration of the opiate antagonist naloxone. These findings suggest that increased opiate transmission may contribute to the pathogenesis of TD. Further investigation of the role of opiate antagonists in treating this disorder are warranted.
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DOI: 10.1002/mds.870080405
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993">1993</date><biblScope unit="vol">8</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="445">445</biblScope><biblScope unit="page" to="452">452</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6D32AB1A71F3D33C21AB1886BBF4ABC489409C62</idno><idno type="DOI">10.1002/mds.870080405</idno><idno type="ArticleID">MDS870080405</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Neuroleptics</term><term>Opiates</term><term>Rat</term><term>Tardive dyskinesia</term><term>Vacuous chewing mouth movements (VCMs)</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of both opiate agonists and the opiate antagonist naloxone were examined in a rodent model of tardive dyskinesia (TD). Chronic (˜20 weeks) administration of fluphenazine resulted in the emergence of vacuous chewing mouth movements (VCMs), a response which may be a useful model for this disorder. Fluphenazine‐induced VCMs were not affected by a variety of selective opiate agonists administered intracerebroventricularly, but were potently suppressed by subcutaneous administration of the opiate antagonist naloxone. These findings suggest that increased opiate transmission may contribute to the pathogenesis of TD. Further investigation of the role of opiate antagonists in treating this disorder are warranted.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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