Short‐term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross‐over trial
Identifieur interne : 001834 ( Istex/Curation ); précédent : 001833; suivant : 001835Short‐term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross‐over trial
Auteurs : Carmine Vitale [Italie] ; Stefano Marconi [Italie] ; Luigi Di Maio [Italie] ; Giuseppe De Michele [Italie] ; Katia Longo [Italie] ; Vincenzo Bonavita [Italie] ; Paolo Barone [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-12-15.
English descriptors
Abstract
We evaluated tolerability and the efficacy of continuous infusion of apomorphine hydrochloride on involuntary movements and mood disorder in Huntington's disease (HD) patients in a pilot, single center, double‐blind, randomized, crossover, and controlled versus placebo study. Nine patients with a molecular diagnosis of HD were screened for response to acute apomorphine injection. Four of them, not ameliorating at the acute test, were discontinued. Five patients, responding to acute apomorphine, received continuous infusion of either apomorphine or placebo for 5 days. After 2 days of washout, the alternative treatment was administered. Primary endpoint measures were scores of the Unified Huntington's Disease Rating Scale (UHDRS “motor section”) and of the Abnormal Involuntary Movement Scale (AIMS). Secondary endpoint measures were the Hamilton Depression Rating Scale (HAD) score and safety parameters. Both UHDRS and AIMS scores significantly decreased in all patients after apomorphine. The beneficial effect of apomorphine was recorded throughout the 5 treatment days. The HAD score did not change after infusion of either treatment. No serious adverse events were reported by either group during the study. Our results suggest that continuous infusion of apomorphine might be considered for the treatment of involuntary movements in some HD patients. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21718
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001834
Links to Exploration step
ISTEX:D118BE4D0F5146C056706F619DE155BBCC3A9E32Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short‐term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross‐over trial</title><author><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Marconi, Stefano" sort="Marconi, Stefano" uniqKey="Marconi S" first="Stefano" last="Marconi">Stefano Marconi</name><affiliation wicri:level="1"><mods:affiliation>Medical Department, Chiesi Farmaceutici S.p.A., Parma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Department, Chiesi Farmaceutici S.p.A., Parma</wicri:regionArea></affiliation></author><author><name sortKey="Di Maio, Luigi" sort="Di Maio, Luigi" uniqKey="Di Maio L" first="Luigi" last="Di Maio">Luigi Di Maio</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Bonavita, Vincenzo" sort="Bonavita, Vincenzo" uniqKey="Bonavita V" first="Vincenzo" last="Bonavita">Vincenzo Bonavita</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D118BE4D0F5146C056706F619DE155BBCC3A9E32</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21718</idno><idno type="url">https://api.istex.fr/document/D118BE4D0F5146C056706F619DE155BBCC3A9E32/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001834</idno><idno type="wicri:Area/Istex/Curation">001834</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Short‐term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross‐over trial</title><author><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Marconi, Stefano" sort="Marconi, Stefano" uniqKey="Marconi S" first="Stefano" last="Marconi">Stefano Marconi</name><affiliation wicri:level="1"><mods:affiliation>Medical Department, Chiesi Farmaceutici S.p.A., Parma, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Department, Chiesi Farmaceutici S.p.A., Parma</wicri:regionArea></affiliation></author><author><name sortKey="Di Maio, Luigi" sort="Di Maio, Luigi" uniqKey="Di Maio L" first="Luigi" last="Di Maio">Luigi Di Maio</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Bonavita, Vincenzo" sort="Bonavita, Vincenzo" uniqKey="Bonavita V" first="Vincenzo" last="Bonavita">Vincenzo Bonavita</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples</wicri:regionArea></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University “Federico II,” Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University “Federico II,” Naples</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-12-15">2007-12-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2359">2359</biblScope><biblScope unit="page" to="2364">2364</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D118BE4D0F5146C056706F619DE155BBCC3A9E32</idno><idno type="DOI">10.1002/mds.21718</idno><idno type="ArticleID">MDS21718</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term><term>apomorphine hydrochloride</term><term>continuous infusion</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated tolerability and the efficacy of continuous infusion of apomorphine hydrochloride on involuntary movements and mood disorder in Huntington's disease (HD) patients in a pilot, single center, double‐blind, randomized, crossover, and controlled versus placebo study. Nine patients with a molecular diagnosis of HD were screened for response to acute apomorphine injection. Four of them, not ameliorating at the acute test, were discontinued. Five patients, responding to acute apomorphine, received continuous infusion of either apomorphine or placebo for 5 days. After 2 days of washout, the alternative treatment was administered. Primary endpoint measures were scores of the Unified Huntington's Disease Rating Scale (UHDRS “motor section”) and of the Abnormal Involuntary Movement Scale (AIMS). Secondary endpoint measures were the Hamilton Depression Rating Scale (HAD) score and safety parameters. Both UHDRS and AIMS scores significantly decreased in all patients after apomorphine. The beneficial effect of apomorphine was recorded throughout the 5 treatment days. The HAD score did not change after infusion of either treatment. No serious adverse events were reported by either group during the study. Our results suggest that continuous infusion of apomorphine might be considered for the treatment of involuntary movements in some HD patients. © 2007 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001834 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001834 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:D118BE4D0F5146C056706F619DE155BBCC3A9E32
|texte= Short‐term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross‐over trial
}}
| This area was generated with Dilib version V0.6.23. |  |