Interference of rhythmic constraint on gait in healthy subjects and patients with early parkinson's disease: Evidence for impaired locomotor pattern generation in early Parkinson's disease
Identifieur interne : 001746 ( Istex/Curation ); précédent : 001745; suivant : 001747Interference of rhythmic constraint on gait in healthy subjects and patients with early parkinson's disease: Evidence for impaired locomotor pattern generation in early Parkinson's disease
Auteurs : Georg Ebersbach [Allemagne] ; Michaela Heijmenberg [Allemagne] ; Leonie Kindermann [Allemagne] ; Thomas Trottenberg [Allemagne] ; Jörg Wissel [Autriche] ; Werner Poewe [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1999-07.
English descriptors
- KwdEn :
Abstract
Patients in the early stages of Parkinson's disease have been shown to walk slower with smaller steps, resembling the gait of normal elderly subjects, but specific disorders of dynamic equilibrium or rhythmic gait patterning have not yet been identified. In the present study, gait control in 22 healthy subjects and 22 patients with early Parkinson's disease was challenged by means of a paradigm requiring subjects to decrease their step rate (cadence) by 20% in response to a metronome signal (rhythmic constraint). Control subjects and patients were matched for age, sex, and body height. Eleven patients were receiving standard antiparkinsonian therapy and were assessed under their ongoing medication, whereas the remaining 11 patients had not yet been started on dopaminergic therapy (“de novo” Parkinson's disease). Gait parameters reflecting dynamic equilibrium (double‐support time) and locomotor patterning (step length, stride duration) were recorded by means of a mechanical device (locometer). Sixteen patients and 16 control subjects were able to accomplish the task. Whereas regulation of step length became irregular during rhythmic constraint in both patients and control subjects, irregular timing of steps was only observed in patients suggesting disturbance of periodic locomotor activity generation.
Url:
DOI: 10.1002/1531-8257(199907)14:4<619::AID-MDS1011>3.0.CO;2-X
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001746
Links to Exploration step
ISTEX:5A253FE4D109CC26198BFB9D994CEAD14EDB4E38Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interference of rhythmic constraint on gait in healthy subjects and patients with early parkinson's disease: Evidence for impaired locomotor pattern generation in early Parkinson's disease</title><author><name sortKey="Ebersbach, Georg" sort="Ebersbach, Georg" uniqKey="Ebersbach G" first="Georg" last="Ebersbach">Georg Ebersbach</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Heijmenberg, Michaela" sort="Heijmenberg, Michaela" uniqKey="Heijmenberg M" first="Michaela" last="Heijmenberg">Michaela Heijmenberg</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Kindermann, Leonie" sort="Kindermann, Leonie" uniqKey="Kindermann L" first="Leonie" last="Kindermann">Leonie Kindermann</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Trottenberg, Thomas" sort="Trottenberg, Thomas" uniqKey="Trottenberg T" first="Thomas" last="Trottenberg">Thomas Trottenberg</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Wissel, Jorg" sort="Wissel, Jorg" uniqKey="Wissel J" first="Jörg" last="Wissel">Jörg Wissel</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinik Innsbruck, Department of Neurology, Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Universitätsklinik Innsbruck, Department of Neurology, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5A253FE4D109CC26198BFB9D994CEAD14EDB4E38</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1002/1531-8257(199907)14:4<619::AID-MDS1011>3.0.CO;2-X</idno><idno type="url">https://api.istex.fr/document/5A253FE4D109CC26198BFB9D994CEAD14EDB4E38/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001746</idno><idno type="wicri:Area/Istex/Curation">001746</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Interference of rhythmic constraint on gait in healthy subjects and patients with early parkinson's disease: Evidence for impaired locomotor pattern generation in early Parkinson's disease</title><author><name sortKey="Ebersbach, Georg" sort="Ebersbach, Georg" uniqKey="Ebersbach G" first="Georg" last="Ebersbach">Georg Ebersbach</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Heijmenberg, Michaela" sort="Heijmenberg, Michaela" uniqKey="Heijmenberg M" first="Michaela" last="Heijmenberg">Michaela Heijmenberg</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Kindermann, Leonie" sort="Kindermann, Leonie" uniqKey="Kindermann L" first="Leonie" last="Kindermann">Leonie Kindermann</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Trottenberg, Thomas" sort="Trottenberg, Thomas" uniqKey="Trottenberg T" first="Thomas" last="Trottenberg">Thomas Trottenberg</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Wissel, Jorg" sort="Wissel, Jorg" uniqKey="Wissel J" first="Jörg" last="Wissel">Jörg Wissel</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinik Innsbruck, Department of Neurology, Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Universitätsklinik Innsbruck, Department of Neurology, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><mods:affiliation>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Rudolf Virchow, Department of Neurology, Berlin</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-07">1999-07</date><biblScope unit="vol">14</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="619">619</biblScope><biblScope unit="page" to="625">625</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5A253FE4D109CC26198BFB9D994CEAD14EDB4E38</idno><idno type="DOI">10.1002/1531-8257(199907)14:4<619::AID-MDS1011>3.0.CO;2-X</idno><idno type="ArticleID">MDS1011</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gait</term><term>Parkinson's disease</term><term>Rhythmic movement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients in the early stages of Parkinson's disease have been shown to walk slower with smaller steps, resembling the gait of normal elderly subjects, but specific disorders of dynamic equilibrium or rhythmic gait patterning have not yet been identified. In the present study, gait control in 22 healthy subjects and 22 patients with early Parkinson's disease was challenged by means of a paradigm requiring subjects to decrease their step rate (cadence) by 20% in response to a metronome signal (rhythmic constraint). Control subjects and patients were matched for age, sex, and body height. Eleven patients were receiving standard antiparkinsonian therapy and were assessed under their ongoing medication, whereas the remaining 11 patients had not yet been started on dopaminergic therapy (“de novo” Parkinson's disease). Gait parameters reflecting dynamic equilibrium (double‐support time) and locomotor patterning (step length, stride duration) were recorded by means of a mechanical device (locometer). Sixteen patients and 16 control subjects were able to accomplish the task. Whereas regulation of step length became irregular during rhythmic constraint in both patients and control subjects, irregular timing of steps was only observed in patients suggesting disturbance of periodic locomotor activity generation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001746 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001746 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:5A253FE4D109CC26198BFB9D994CEAD14EDB4E38
|texte= Interference of rhythmic constraint on gait in healthy subjects and patients with early parkinson's disease: Evidence for impaired locomotor pattern generation in early Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |