H1/H1 genotype influences symptom severity in corticobasal syndrome
Identifieur interne : 001566 ( Istex/Curation ); précédent : 001565; suivant : 001567H1/H1 genotype influences symptom severity in corticobasal syndrome
Auteurs : Irene Litvan [États-Unis] ; Amanda Chism [États-Unis] ; Juan Litvan [États-Unis] ; Alex Cambon [États-Unis] ; Michael Hutton [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-30.
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Abstract
We evaluated 38 consecutive patients with corticobasal syndrome to determine if inheritance of the H1/H1 genotype influences age at onset and disease severity and if Apolipoprotein E e4 increases the risk of cognitive disturbances. Inheritance of the H1/H1 genotype was associated with severity of motor function, but did not affect age at onset or cognition. There was a trend toward shorter survival in the H1/H1 group, but this study was underpowered to test influence on survival, even though it served to estimate the sample size for future studies. ApoE inheritance did not influence cognition. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22804
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