Parkinsonism and dystonia caused by the illicit use of ephedrone—A longitudinal study
Identifieur interne : 001499 ( Istex/Curation ); précédent : 001498; suivant : 001500Parkinsonism and dystonia caused by the illicit use of ephedrone—A longitudinal study
Auteurs : Marianna Selikhova [Royaume-Uni, Russie] ; Ljuda Fedoryshyn [Ukraine] ; Yuri Matviyenko [Ukraine] ; Irena Komnatska [Ukraine] ; Marianna Kyrylchuk [Ukraine] ; Lesrek Krolicki [Pologne] ; Andrzej Friedman [Pologne] ; Andrew Taylor [Royaume-Uni] ; H. Rolf J Ger [Royaume-Uni] ; Andrew Lees [Royaume-Uni] ; Yanush Sanotsky [Ukraine]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-11-15.
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Abstract
A neurological syndrome characterized by levodopa unresponsive bradykinesia, retropulsion with falls backwards, dysarthria, gait disturbance, dystonia, and emotional lability was identified in 13 male opiate addicts following the prolonged intravenous use of ephedrone (methcathinone), a central nervous stimulant prepared from pseudoephedrine, potassium permanganate, and vinegar. The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chronic manganese poisoning and increased mean manganese level in pubic hair observed for at least 1 year after cessation of ephedrone. Odor identification was intact. Cognitive assessment showed a mild executive dysfunction and a mild depression. DaTSCANs were all normal. The neurological syndrome bears some similarities to PSP but differs from Parkinson's disease. Delayed neurological progression despite discontinuation of ephedrone occurred in one‐third of cases. Ephedrone poisoning should be considered as a possible cause of secondary Parkinsonism in young adults, particularly from Eastern Europe. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22290
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sort="Friedman, Andrzej" uniqKey="Friedman A" first="Andrzej" last="Friedman">Andrzej Friedman</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Medical University of Warsaw, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Warsaw, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name><affiliation wicri:level="1"><mods:affiliation>Centre for Clinical Science and Measurement, University of Surrey, Guildford, Surrey, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Clinical Science and Measurement, University of Surrey, Guildford, Surrey</wicri:regionArea></affiliation></author><author><name sortKey="J Ger, H Rolf" sort="J Ger, H Rolf" uniqKey="J Ger H" first="H. Rolf" last="J Ger">H. Rolf J Ger</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroimaging, Institute of Neurology, UCL, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuroimaging, Institute of Neurology, UCL</wicri:regionArea></affiliation></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, UCL, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, Reta Lila Weston Institute of Neurological Studies, UCL</wicri:regionArea></affiliation></author><author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Lviv Regional Clinical Hospital, Lviv, Ukraine</mods:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Department of Neurology, Lviv Regional Clinical Hospital, Lviv</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-11-15">2008-11-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2224">2224</biblScope><biblScope unit="page" to="2231">2231</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A5B9BF0F3432F8C3619BD658411FA5258C39BFB5</idno><idno type="DOI">10.1002/mds.22290</idno><idno type="ArticleID">MDS22290</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinsonism</term><term>dystonia</term><term>ephedrine</term><term>globus pallidum</term><term>manganism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A neurological syndrome characterized by levodopa unresponsive bradykinesia, retropulsion with falls backwards, dysarthria, gait disturbance, dystonia, and emotional lability was identified in 13 male opiate addicts following the prolonged intravenous use of ephedrone (methcathinone), a central nervous stimulant prepared from pseudoephedrine, potassium permanganate, and vinegar. The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chronic manganese poisoning and increased mean manganese level in pubic hair observed for at least 1 year after cessation of ephedrone. Odor identification was intact. Cognitive assessment showed a mild executive dysfunction and a mild depression. DaTSCANs were all normal. The neurological syndrome bears some similarities to PSP but differs from Parkinson's disease. Delayed neurological progression despite discontinuation of ephedrone occurred in one‐third of cases. Ephedrone poisoning should be considered as a possible cause of secondary Parkinsonism in young adults, particularly from Eastern Europe. © 2008 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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