Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy
Identifieur interne : 001465 ( Istex/Curation ); précédent : 001464; suivant : 001466Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy
Auteurs : Martin Köllensperger [Autriche] ; Klaus Seppi [Autriche] ; Claudia Liener [Autriche] ; Sylvia Boesch [Autriche] ; Dirk Heute [Autriche] ; Katherina J. Mair [Autriche] ; Joerg Mueller [Autriche] ; Martin Sawires [Autriche] ; Christoph Scherfler [Autriche] ; Michael F. Schocke [Autriche] ; Eveline Donnemilier [Autriche] ; Irene Virgolini [Autriche] ; Gregor K. Wenning [Autriche] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-09-15.
English descriptors
Abstract
Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta‐iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA‐P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA‐P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA‐P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA‐P. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21614
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Mair</name><affiliation wicri:level="1"><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Mueller, Joerg" sort="Mueller, Joerg" uniqKey="Mueller J" first="Joerg" last="Mueller">Joerg Mueller</name><affiliation wicri:level="1"><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name><affiliation wicri:level="1"><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><affiliation wicri:level="1"><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Schocke, Michael F" sort="Schocke, Michael F" uniqKey="Schocke M" first="Michael F." last="Schocke">Michael F. Schocke</name><affiliation wicri:level="1"><mods:affiliation>Department of Radiology I, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Radiology I, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Donnemilier, Eveline" sort="Donnemilier, Eveline" uniqKey="Donnemilier E" first="Eveline" last="Donnemilier">Eveline Donnemilier</name><affiliation wicri:level="1"><mods:affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Virgolini, Irene" sort="Virgolini, Irene" uniqKey="Virgolini I" first="Irene" last="Virgolini">Irene Virgolini</name><affiliation wicri:level="1"><mods:affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation wicri:level="1"><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-09-15">2007-09-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1771">1771</biblScope><biblScope unit="page" to="1776">1776</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A102EE0D4B9850C17E566F570FC6BA81BF454B28</idno><idno type="DOI">10.1002/mds.21614</idno><idno type="ArticleID">MDS21614</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MIBG scintigraphy</term><term>Parkinson's disease</term><term>diffusion weighted imaging</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta‐iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA‐P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA‐P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA‐P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA‐P. © 2007 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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