Lesion of the centromedian thalamic nucleus in MPTP‐treated monkeys
Identifieur interne : 001337 ( Istex/Curation ); précédent : 001336; suivant : 001338Lesion of the centromedian thalamic nucleus in MPTP‐treated monkeys
Auteurs : Jose L. Lanciego [Espagne] ; Maria C. Rodríguez-Oroz [Espagne] ; Francisco J. Blesa [Espagne] ; Lydia Alvarez-Erviti [Espagne] ; Jorge Guridi [Espagne] ; Pedro Barroso-Chinea [Espagne] ; Yoland Smith [États-Unis] ; Jose A. Obeso [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
English descriptors
Abstract
The caudal intralaminar nuclei are a major source of glutamatergic afferents to the basal ganglia. Experiments in the 6‐hydroxydopamine rat model have shown that the parafascicular nucleus is overactive and its lesion alleviates basal ganglia neurochemical abnormalities associated with dopamine depletion. Accordingly, removal of this excitatory innervation of the basal ganglia could have a beneficial value in the parkinsonian state. To test this hypothesis, unilateral kainate‐induced chemical ablation of the centromedian thalamic nucleus (CM) has been performed in MPTP‐treated monkeys. Successful lesions restricted to the CM boundaries (n = 2) without spreading over other neighboring thalamic nuclei showed an initial, short‐lasting, and mild change in the parkinsonian motor scale but no effect against levodopa‐induced dyskinesias. The lack of significant and persistent motor improvement leads us to conclude that unilateral selective lesion of the CM alone cannot be considered as a suitable surgical approach for the treatment of PD or levodopa‐induced dyskinesias. The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21906
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Blesa</name><affiliation wicri:level="1"><mods:affiliation>Neurosciences Division, CIMA, Pamplona, University of Navarra, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurosciences Division, CIMA, Pamplona, University of Navarra</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author><author><name sortKey="Alvarez Rviti, Lydia" sort="Alvarez Rviti, Lydia" uniqKey="Alvarez Rviti L" first="Lydia" last="Alvarez-Erviti">Lydia Alvarez-Erviti</name><affiliation wicri:level="1"><mods:affiliation>Neurosciences Division, CIMA, Pamplona, University of Navarra, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurosciences Division, CIMA, Pamplona, University of Navarra</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation wicri:level="1"><mods:affiliation>Neurosciences Division, CIMA, Pamplona, University of Navarra, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurosciences Division, CIMA, Pamplona, University of Navarra</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, University of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, University of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Barroso Hinea, Pedro" sort="Barroso Hinea, Pedro" uniqKey="Barroso Hinea P" first="Pedro" last="Barroso-Chinea">Pedro Barroso-Chinea</name><affiliation wicri:level="1"><mods:affiliation>Neurosciences Division, CIMA, Pamplona, University of Navarra, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurosciences Division, CIMA, Pamplona, University of Navarra</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Yoland" sort="Smith, Yoland" uniqKey="Smith Y" first="Yoland" last="Smith">Yoland Smith</name><affiliation wicri:level="1"><mods:affiliation>Division of Neurosciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurosciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Emory University, Atlanta, Georgia, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><mods:affiliation>Neurosciences Division, CIMA, Pamplona, University of Navarra, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurosciences Division, CIMA, Pamplona, University of Navarra</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, University of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, University of Navarra, Pamplona</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04-15">2008-04-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="708">708</biblScope><biblScope unit="page" to="715">715</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">565E353B929FBAA783CEA26593099201166DAEB2</idno><idno type="DOI">10.1002/mds.21906</idno><idno type="ArticleID">MDS21906</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MPTP monkey model</term><term>Parkinson's disease</term><term>intralaminar thalamic nuclei</term><term>kainic acid lesion</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The caudal intralaminar nuclei are a major source of glutamatergic afferents to the basal ganglia. Experiments in the 6‐hydroxydopamine rat model have shown that the parafascicular nucleus is overactive and its lesion alleviates basal ganglia neurochemical abnormalities associated with dopamine depletion. Accordingly, removal of this excitatory innervation of the basal ganglia could have a beneficial value in the parkinsonian state. To test this hypothesis, unilateral kainate‐induced chemical ablation of the centromedian thalamic nucleus (CM) has been performed in MPTP‐treated monkeys. Successful lesions restricted to the CM boundaries (n = 2) without spreading over other neighboring thalamic nuclei showed an initial, short‐lasting, and mild change in the parkinsonian motor scale but no effect against levodopa‐induced dyskinesias. The lack of significant and persistent motor improvement leads us to conclude that unilateral selective lesion of the CM alone cannot be considered as a suitable surgical approach for the treatment of PD or levodopa‐induced dyskinesias. The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified. © 2007 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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