Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients
Identifieur interne : 001247 ( Istex/Curation ); précédent : 001246; suivant : 001248Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients
Auteurs : Tim Anderson [Nouvelle-Zélande] ; Linda Luxon [Royaume-Uni] ; Niall Quinn [Royaume-Uni] ; Susan Daniel [Royaume-Uni] ; C. David Marsden [Nouvelle-Zélande] ; Adolfo Bronstein [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
English descriptors
- KwdEn :
Abstract
We reviewed the clinical and laboratory oculomotor features in 30 patients with probable multiple system atrophy (MSA), 22 with MSA‐P and 8 with MSA‐C. Six patients were also examined post mortem, MSA being confirmed in four and excluded in two (Parkinson's disease and progressive supranuclear palsy). Clinical examination showed the following abnormalities; excessive square wave jerks—21 of 30 patients; mild vertical supranuclear gaze palsy—8 of 30; gaze‐evoked nystagmus—12 of 30 patients, three of whom had no extraocular evidence of cerebellar dysfunction; positioning downbeat nystagmus—10 of 25; mild or moderate saccadic hypometria—22 of 30; impaired (“broken up”) smooth pursuit—28 of 30; reduced VOR suppression—16 of 24. Electro‐oculography and caloric testing did not add significant extra information. In patients presenting with an akinetic‐rigid syndrome it can be difficult to differentiate idiopathic Parkinson's disease from MSA‐P and other causes of atypical parkinsonism. Our findings suggest that the presence of excessive square wave jerks, mild – moderate hypometria of saccades, impaired VOR suppression, spontaneous nystagmus or positioning downbeat nystagmus may be oculomotor “red flags” or clues to the presence of MSA. Further, the presence of clinically slow saccades, or moderate‐to‐severe gaze restriction, suggests a diagnosis other than MSA. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21999
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001247
Links to Exploration step
ISTEX:3D3FD14B982659679FAD68B5BA492EEFE0F0F699Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients</title><author><name sortKey="Anderson, Tim" sort="Anderson, Tim" uniqKey="Anderson T" first="Tim" last="Anderson">Tim Anderson</name><affiliation wicri:level="1"><mods:affiliation>Van Der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</mods:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van Der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea></affiliation></author><author><name sortKey="Luxon, Linda" sort="Luxon, Linda" uniqKey="Luxon L" first="Linda" last="Luxon">Linda Luxon</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuro‐otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuro‐otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name><affiliation wicri:level="1"><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Daniel, Susan" sort="Daniel, Susan" uniqKey="Daniel S" first="Susan" last="Daniel">Susan Daniel</name><affiliation wicri:level="1"><mods:affiliation>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="David Marsden, C" sort="David Marsden, C" uniqKey="David Marsden C" first="C." last="David Marsden">C. David Marsden</name><affiliation wicri:level="1"><mods:affiliation>Van Der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</mods:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van Der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea></affiliation></author><author><name sortKey="Bronstein, Adolfo" sort="Bronstein, Adolfo" uniqKey="Bronstein A" first="Adolfo" last="Bronstein">Adolfo Bronstein</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuro‐otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuro‐otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Division of Neurosciences and Mental Health, Medicine, Imperial College, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Neurosciences and Mental Health, Medicine, Imperial College, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3D3FD14B982659679FAD68B5BA492EEFE0F0F699</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.21999</idno><idno type="url">https://api.istex.fr/document/3D3FD14B982659679FAD68B5BA492EEFE0F0F699/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001247</idno><idno type="wicri:Area/Istex/Curation">001247</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients</title><author><name sortKey="Anderson, Tim" sort="Anderson, Tim" uniqKey="Anderson T" first="Tim" last="Anderson">Tim Anderson</name><affiliation wicri:level="1"><mods:affiliation>Van Der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</mods:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van Der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea></affiliation></author><author><name sortKey="Luxon, Linda" sort="Luxon, Linda" uniqKey="Luxon L" first="Linda" last="Luxon">Linda Luxon</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuro‐otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuro‐otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name><affiliation wicri:level="1"><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Daniel, Susan" sort="Daniel, Susan" uniqKey="Daniel S" first="Susan" last="Daniel">Susan Daniel</name><affiliation wicri:level="1"><mods:affiliation>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="David Marsden, C" sort="David Marsden, C" uniqKey="David Marsden C" first="C." last="David Marsden">C. David Marsden</name><affiliation wicri:level="1"><mods:affiliation>Van Der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</mods:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Van Der Veer Institute for Parkinson's and Brain Research, Christchurch</wicri:regionArea></affiliation></author><author><name sortKey="Bronstein, Adolfo" sort="Bronstein, Adolfo" uniqKey="Bronstein A" first="Adolfo" last="Bronstein">Adolfo Bronstein</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuro‐otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuro‐otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Division of Neurosciences and Mental Health, Medicine, Imperial College, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Neurosciences and Mental Health, Medicine, Imperial College, London</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-05-15">2008-05-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="977">977</biblScope><biblScope unit="page" to="984">984</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3D3FD14B982659679FAD68B5BA492EEFE0F0F699</idno><idno type="DOI">10.1002/mds.21999</idno><idno type="ArticleID">MDS21999</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>multiple system atrophy (MSA)</term><term>oculomotor</term><term>pathology</term><term>positioning downbeat nystagmus (pDBN)</term><term>saccades</term><term>vestibular</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We reviewed the clinical and laboratory oculomotor features in 30 patients with probable multiple system atrophy (MSA), 22 with MSA‐P and 8 with MSA‐C. Six patients were also examined post mortem, MSA being confirmed in four and excluded in two (Parkinson's disease and progressive supranuclear palsy). Clinical examination showed the following abnormalities; excessive square wave jerks—21 of 30 patients; mild vertical supranuclear gaze palsy—8 of 30; gaze‐evoked nystagmus—12 of 30 patients, three of whom had no extraocular evidence of cerebellar dysfunction; positioning downbeat nystagmus—10 of 25; mild or moderate saccadic hypometria—22 of 30; impaired (“broken up”) smooth pursuit—28 of 30; reduced VOR suppression—16 of 24. Electro‐oculography and caloric testing did not add significant extra information. In patients presenting with an akinetic‐rigid syndrome it can be difficult to differentiate idiopathic Parkinson's disease from MSA‐P and other causes of atypical parkinsonism. Our findings suggest that the presence of excessive square wave jerks, mild – moderate hypometria of saccades, impaired VOR suppression, spontaneous nystagmus or positioning downbeat nystagmus may be oculomotor “red flags” or clues to the presence of MSA. Further, the presence of clinically slow saccades, or moderate‐to‐severe gaze restriction, suggests a diagnosis other than MSA. © 2008 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001247 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001247 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:3D3FD14B982659679FAD68B5BA492EEFE0F0F699
|texte= Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients
}}
| This area was generated with Dilib version V0.6.23. |  |