Diffusion‐weighted imaging in multiple system atrophy: A comparison between clinical subtypes
Identifieur interne : 001105 ( Istex/Curation ); précédent : 001104; suivant : 001106Diffusion‐weighted imaging in multiple system atrophy: A comparison between clinical subtypes
Auteurs : Maria Teresa Pellecchia [Italie] ; Paolo Barone [Italie] ; Carmine Mollica [Italie] ; Elena Salvatore [Italie] ; Marta Ianniciello [Italie] ; Katia Longo [Italie] ; Andrea Varrone [Italie] ; Caterina Vicidomini [Italie] ; Marina Picillo [Italie] ; Giuseppe De Michele [Italie] ; Alessandro Filla [Italie] ; Marco Salvatore [Italie] ; Sabina Pappatà [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
English descriptors
Abstract
Multiple system atrophy can be classified into two main types, a Parkinsonian (MSA‐P) and a cerebellar (MSA‐C) variant based on clinical presentation. We obtained diffusion‐weighted magnetic resonance imaging (DWI) in 9 MSA‐P and 12 MSA‐C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA‐P than in MSA‐C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA‐C than in MSA‐P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA‐P patients, and in cerebellum and MCP of MSA‐C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA‐P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA‐P and MSA‐C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurodegeneration in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA‐P patients and in the cerebellum and MCP in MSA‐C patients could serve as quantitative markers for microstructural damage in the course of disease. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22440
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xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Vicidomini, Caterina" sort="Vicidomini, Caterina" uniqKey="Vicidomini C" first="Caterina" last="Vicidomini">Caterina Vicidomini</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University Federico II, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University Federico II, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, University Federico II, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappatà">Sabina Pappatà</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-15">2009-04-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="689">689</biblScope><biblScope unit="page" to="696">696</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9C2467DD40413763671EA31CD67CBF09EE8A5AD8</idno><idno type="DOI">10.1002/mds.22440</idno><idno type="ArticleID">MDS22440</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MSA subtypes</term><term>diffusion‐weighted imaging</term><term>magnetic resonance imaging</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy can be classified into two main types, a Parkinsonian (MSA‐P) and a cerebellar (MSA‐C) variant based on clinical presentation. We obtained diffusion‐weighted magnetic resonance imaging (DWI) in 9 MSA‐P and 12 MSA‐C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA‐P than in MSA‐C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA‐C than in MSA‐P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA‐P patients, and in cerebellum and MCP of MSA‐C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA‐P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA‐P and MSA‐C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurodegeneration in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA‐P patients and in the cerebellum and MCP in MSA‐C patients could serve as quantitative markers for microstructural damage in the course of disease. © 2008 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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