Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: A randomized controlled trial
Identifieur interne : 001073 ( Istex/Curation ); précédent : 001072; suivant : 001074Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: A randomized controlled trial
Auteurs : Yoshihiro Sato [Japon] ; Jun Iwamoto [Japon] ; Tomohiro Kanoko [Japon] ; Kei Satoh [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
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Abstract
Incidence of a fracture, particularly in the hip joint, is high in elderly women with Parkinson's disease (PD), and this is due to the immobilization‐induced bone resorption and vitamin D deficiency with reduced bone mineral density (BMD). The objective of this study was to address the possibility that treatment with alendronate and vitamin D2 may reduce the incidence of hip fractures in elderly women with PD. PD patients were randomly assigned to daily treatment with 5 mg alendronate (n = 144) or a placebo combined with 1,000 IU of vitamin D2 (n = 144) and followed for 2 years. Incidence of hip fractures in the two patient groups during the 2‐year follow‐up period was studied. At baseline, both groups of patients had low BMD with high levels of serum‐ionized calcium and urinary deoxypyridinoline (D‐Pyr). Hip fractures occurred in 14 patients in the placebo group and 4 in the alendronate group. The relative risk for hip fractures in the alendronate group as compared with the placebo group was 0.29 (95% CI, 0.10–0.85). The number of hip fracture per 1,000 patient‐years was 14 and 49 for the alendronate and placebo groups, respectively. In the alendronate group, serum calcium and urinary D‐Pyr levels decreased significantly during the follow‐up period, while the levels in the placebo group were increased. BMD increased by 3.1% in the alendronate group and decreased by 2.8% in the placebo group (P < 0.01). Treatment with alendronate and vitamin D2 increases BMD in elderly women with PD and leads to the prevention of hip fractures. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20825
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: A randomized controlled trial</title><author><name sortKey="Sato, Yoshihiro" sort="Sato, Yoshihiro" uniqKey="Sato Y" first="Yoshihiro" last="Sato">Yoshihiro Sato</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Mitate Hospital, Tagawa, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Mitate Hospital, Tagawa</wicri:regionArea></affiliation></author><author><name sortKey="Iwamoto, Jun" sort="Iwamoto, Jun" uniqKey="Iwamoto J" first="Jun" last="Iwamoto">Jun Iwamoto</name><affiliation wicri:level="1"><mods:affiliation>Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Sports Medicine, Keio University School of Medicine, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kanoko, Tomohiro" sort="Kanoko, Tomohiro" uniqKey="Kanoko T" first="Tomohiro" last="Kanoko">Tomohiro Kanoko</name><affiliation wicri:level="1"><mods:affiliation>Department of Rehabilitation Medicine, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rehabilitation Medicine, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea></affiliation></author><author><name sortKey="Satoh, Kei" sort="Satoh, Kei" uniqKey="Satoh K" first="Kei" last="Satoh">Kei Satoh</name><affiliation wicri:level="1"><mods:affiliation>Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B32FD1A39905B841FDF0E6F60A13D417FED9580F</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/mds.20825</idno><idno type="url">https://api.istex.fr/document/B32FD1A39905B841FDF0E6F60A13D417FED9580F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001073</idno><idno type="wicri:Area/Istex/Curation">001073</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: A randomized controlled trial</title><author><name sortKey="Sato, Yoshihiro" sort="Sato, Yoshihiro" uniqKey="Sato Y" first="Yoshihiro" last="Sato">Yoshihiro Sato</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Mitate Hospital, Tagawa, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Mitate Hospital, Tagawa</wicri:regionArea></affiliation></author><author><name sortKey="Iwamoto, Jun" sort="Iwamoto, Jun" uniqKey="Iwamoto J" first="Jun" last="Iwamoto">Jun Iwamoto</name><affiliation wicri:level="1"><mods:affiliation>Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Sports Medicine, Keio University School of Medicine, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kanoko, Tomohiro" sort="Kanoko, Tomohiro" uniqKey="Kanoko T" first="Tomohiro" last="Kanoko">Tomohiro Kanoko</name><affiliation wicri:level="1"><mods:affiliation>Department of Rehabilitation Medicine, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rehabilitation Medicine, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea></affiliation></author><author><name sortKey="Satoh, Kei" sort="Satoh, Kei" uniqKey="Satoh K" first="Kei" last="Satoh">Kei Satoh</name><affiliation wicri:level="1"><mods:affiliation>Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="924">924</biblScope><biblScope unit="page" to="929">929</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B32FD1A39905B841FDF0E6F60A13D417FED9580F</idno><idno type="DOI">10.1002/mds.20825</idno><idno type="ArticleID">MDS20825</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>alendronate</term><term>hip fracture</term><term>hypercalcemia</term><term>vitamin D</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Incidence of a fracture, particularly in the hip joint, is high in elderly women with Parkinson's disease (PD), and this is due to the immobilization‐induced bone resorption and vitamin D deficiency with reduced bone mineral density (BMD). The objective of this study was to address the possibility that treatment with alendronate and vitamin D2 may reduce the incidence of hip fractures in elderly women with PD. PD patients were randomly assigned to daily treatment with 5 mg alendronate (n = 144) or a placebo combined with 1,000 IU of vitamin D2 (n = 144) and followed for 2 years. Incidence of hip fractures in the two patient groups during the 2‐year follow‐up period was studied. At baseline, both groups of patients had low BMD with high levels of serum‐ionized calcium and urinary deoxypyridinoline (D‐Pyr). Hip fractures occurred in 14 patients in the placebo group and 4 in the alendronate group. The relative risk for hip fractures in the alendronate group as compared with the placebo group was 0.29 (95% CI, 0.10–0.85). The number of hip fracture per 1,000 patient‐years was 14 and 49 for the alendronate and placebo groups, respectively. In the alendronate group, serum calcium and urinary D‐Pyr levels decreased significantly during the follow‐up period, while the levels in the placebo group were increased. BMD increased by 3.1% in the alendronate group and decreased by 2.8% in the placebo group (P < 0.01). Treatment with alendronate and vitamin D2 increases BMD in elderly women with PD and leads to the prevention of hip fractures. © 2006 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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