Abnormal activity of membrane phospholipid synthetic enzymes in the brain of patients with Friedreich's ataxia and spinocerebellar atrophy type‐1
Identifieur interne : 000F10 ( Istex/Curation ); précédent : 000F09; suivant : 000F11Abnormal activity of membrane phospholipid synthetic enzymes in the brain of patients with Friedreich's ataxia and spinocerebellar atrophy type‐1
Auteurs : Brian M. Ross [Canada] ; Klaus Eder [Allemagne] ; Anna Moszczynska [Canada] ; Nikolaos Mamalias [Canada] ; Jacques Lamarche [Canada] ; Lee Ang [Canada] ; Massimo Pandolfo ; Guy Rouleau [Canada] ; Manfred Kirchgessner [Allemagne] ; Stephen J. Kish [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-03.
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Abstract
Much evidence, derived from biochemical studies of both blood and autopsied brain, has suggested that phospholipid metabolism is abnormal in patients with Friedreich's ataxia (FA), a disorder characterized by severe neuronal loss in the spinal cord and lower brain stem with no, or only modest, damage in other brain regions. To establish the cause of our recent finding of reduced brain levels of phospholipids in FA, we assayed activities of 10 phospholipid‐metabolizing enzymes in the autopsied cerebellar cortex of patients with the disorder and, for comparison, in a group of patients with spinocerebellar ataxia type 1 (SCA‐1), a disease characterized, unlike FA, by marked neuronal loss in the cerebellar cortex. Enzyme activities were also measured in four brain areas which are relatively unaffected morphologically in both FA and SCA‐1. We found that ethanolamine kinase activity was increased in multiple brain regions of patients with FA (increased 31%–137%) and, more modestly, in SCA‐1 (increased 39%–60%), suggesting a nonspecific enhancement of phosphoethanolamine production in both disorders. In contrast, the activity of phosphoethanolamine cytidylyltransferase (PECT), the rate‐limiting enzyme of phosphatidylethanolamine synthesis, was significantly and markedly decreased by 35%–78% in the cerebellar, frontal, and occipital cortices of patients with FA but was normal in SCA‐1. Reduced PECT activity in FA may explain the lower brain levels of phosphatidylethanolamine in the disorder. Moreover, because decreased PECT activity in FA occurs in brain regions having no, or only modest, morphologic damage, this may represent a systemic change consequent to the frataxin gene defect. Our data also suggest that therapeutic intervention in FA designed to increase synthesis of membrane phospholipids may warrant further investigation.
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DOI: 10.1002/1531-8257(200003)15:2<294::AID-MDS1013>3.0.CO;2-D
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Massimo Pandolfo<affiliation><mods:affiliation>Centre Hospitalier de l' Université de Montréal</mods:affiliation><wicri:noCountry code="no comma">Centre Hospitalier de l' Université de Montréal</wicri:noCountry></affiliation>Le document en format XML
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Ross</name><affiliation wicri:level="1"><mods:affiliation>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Eder, Klaus" sort="Eder, Klaus" uniqKey="Eder K" first="Klaus" last="Eder">Klaus Eder</name><affiliation wicri:level="1"><mods:affiliation>Institute of Nutrition Physiology, Technical University of Munich, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Nutrition Physiology, Technical University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Moszczynska, Anna" sort="Moszczynska, Anna" uniqKey="Moszczynska A" first="Anna" last="Moszczynska">Anna Moszczynska</name><affiliation wicri:level="1"><mods:affiliation>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Mamalias, Nikolaos" sort="Mamalias, Nikolaos" uniqKey="Mamalias N" first="Nikolaos" last="Mamalias">Nikolaos Mamalias</name><affiliation wicri:level="1"><mods:affiliation>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Lamarche, Jacques" sort="Lamarche, Jacques" uniqKey="Lamarche J" first="Jacques" last="Lamarche">Jacques Lamarche</name><affiliation wicri:level="1"><mods:affiliation>Centre Universitaire de Santé de l'Estrie, Sherbrooke, Quebec, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Universitaire de Santé de l'Estrie, Sherbrooke, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Ang, Lee" sort="Ang, Lee" uniqKey="Ang L" first="Lee" last="Ang">Lee Ang</name><affiliation wicri:level="1"><mods:affiliation>Sunnybrook Health Science Centre, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Sunnybrook Health Science Centre, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Pandolfo, Massimo" sort="Pandolfo, Massimo" uniqKey="Pandolfo M" first="Massimo" last="Pandolfo">Massimo Pandolfo</name><affiliation><mods:affiliation>Centre Hospitalier de l' Université de Montréal</mods:affiliation><wicri:noCountry code="no comma">Centre Hospitalier de l' Université de Montréal</wicri:noCountry></affiliation></author><author><name sortKey="Rouleau, Guy" sort="Rouleau, Guy" uniqKey="Rouleau G" first="Guy" last="Rouleau">Guy Rouleau</name><affiliation wicri:level="1"><mods:affiliation>Montreal General Hospital Research Institute, Montreal, Quebec, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal General Hospital Research Institute, Montreal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Kirchgessner, Manfred" sort="Kirchgessner, Manfred" uniqKey="Kirchgessner M" first="Manfred" last="Kirchgessner">Manfred Kirchgessner</name><affiliation wicri:level="1"><mods:affiliation>Institute of Nutrition Physiology, Technical University of Munich, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Nutrition Physiology, Technical University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><affiliation wicri:level="1"><mods:affiliation>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-03">2000-03</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="294">294</biblScope><biblScope unit="page" to="300">300</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">498308B9FD34DE4E58068FB7F2112415E3F46725</idno><idno type="DOI">10.1002/1531-8257(200003)15:2<294::AID-MDS1013>3.0.CO;2-D</idno><idno type="ArticleID">MDS1013</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellar cortex</term><term>Ethanolamine kinase</term><term>Membrane</term><term>Phosphatidylethanolamine</term><term>Phosphoethanolamine cytidylyltransferase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Much evidence, derived from biochemical studies of both blood and autopsied brain, has suggested that phospholipid metabolism is abnormal in patients with Friedreich's ataxia (FA), a disorder characterized by severe neuronal loss in the spinal cord and lower brain stem with no, or only modest, damage in other brain regions. To establish the cause of our recent finding of reduced brain levels of phospholipids in FA, we assayed activities of 10 phospholipid‐metabolizing enzymes in the autopsied cerebellar cortex of patients with the disorder and, for comparison, in a group of patients with spinocerebellar ataxia type 1 (SCA‐1), a disease characterized, unlike FA, by marked neuronal loss in the cerebellar cortex. Enzyme activities were also measured in four brain areas which are relatively unaffected morphologically in both FA and SCA‐1. We found that ethanolamine kinase activity was increased in multiple brain regions of patients with FA (increased 31%–137%) and, more modestly, in SCA‐1 (increased 39%–60%), suggesting a nonspecific enhancement of phosphoethanolamine production in both disorders. In contrast, the activity of phosphoethanolamine cytidylyltransferase (PECT), the rate‐limiting enzyme of phosphatidylethanolamine synthesis, was significantly and markedly decreased by 35%–78% in the cerebellar, frontal, and occipital cortices of patients with FA but was normal in SCA‐1. Reduced PECT activity in FA may explain the lower brain levels of phosphatidylethanolamine in the disorder. Moreover, because decreased PECT activity in FA occurs in brain regions having no, or only modest, morphologic damage, this may represent a systemic change consequent to the frataxin gene defect. Our data also suggest that therapeutic intervention in FA designed to increase synthesis of membrane phospholipids may warrant further investigation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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