Brain dopaminergic modulation associated with executive function in Parkinson's disease
Identifieur interne : 000A45 ( Istex/Curation ); précédent : 000A44; suivant : 000A46Brain dopaminergic modulation associated with executive function in Parkinson's disease
Auteurs : Karim Farid [France] ; Igor Sibon [France] ; Dominique Guehl [France] ; Emmanuel Cuny [France] ; Pierre Burbaud [France] ; Michèle Allard [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-10-15.
English descriptors
Abstract
The progressive development of deficits in executive functions, including action planning, is a well‐known complication of Parkinson's disease. A dysfunction of the prefrontal lobe, which is known to be involved in the control of inhibitory processes, could explain the difficulties in initiating behavior or inhibiting ongoing actions in patients with PD. The strong dopaminergic innervation of the prefrontal cortex raises questions about the putative effects of dopa therapy on this cognitive impairment. In the present study, we used fMRI to examine the functional influence of dopa therapy on neural activity during a go/no‐go task in nine patients with and without levodopa treatment and in matched controls. Whereas the patient and control subjects exhibited the same performance during the go/no‐go task, different patterns of brain activation were observed depending on the dopaminergic status. The drug‐off state was characterized by more widely distributed brain activity, mainly in the bilateral caudate. Levodopa did not fully restore normal brain activation and induced changes in the pattern of cingulate cortex activity, which was more pronounced in the rostral part in the drug‐off state and in the caudal part after levodopa intake. These results support the idea of a critical role for dopamine in the control of executive functions in patients with PD. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22709
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A45
Links to Exploration step
ISTEX:0C62DB0B5BE49F52ECB956002CAA2B853993A84FLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain dopaminergic modulation associated with executive function in Parkinson's disease</title>
<author><name sortKey="Farid, Karim" sort="Farid, Karim" uniqKey="Farid K" first="Karim" last="Farid">Karim Farid</name>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5231, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5231, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sibon, Igor" sort="Sibon, Igor" uniqKey="Sibon I" first="Igor" last="Sibon">Igor Sibon</name>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5231, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5231, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guehl, Dominique" sort="Guehl, Dominique" uniqKey="Guehl D" first="Dominique" last="Guehl">Dominique Guehl</name>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5543, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5543, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cuny, Emmanuel" sort="Cuny, Emmanuel" uniqKey="Cuny E" first="Emmanuel" last="Cuny">Emmanuel Cuny</name>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5543, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5543, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burbaud, Pierre" sort="Burbaud, Pierre" uniqKey="Burbaud P" first="Pierre" last="Burbaud">Pierre Burbaud</name>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5543, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5543, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Allard, Michele" sort="Allard, Michele" uniqKey="Allard M" first="Michèle" last="Allard">Michèle Allard</name>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5231, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5231, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Ecole Pratique des Hautes Etudes (EPHE), Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecole Pratique des Hautes Etudes (EPHE), Paris</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:0C62DB0B5BE49F52ECB956002CAA2B853993A84F</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1002/mds.22709</idno>
<idno type="url">https://api.istex.fr/document/0C62DB0B5BE49F52ECB956002CAA2B853993A84F/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000A45</idno>
<idno type="wicri:Area/Istex/Curation">000A45</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Brain dopaminergic modulation associated with executive function in Parkinson's disease</title>
<author><name sortKey="Farid, Karim" sort="Farid, Karim" uniqKey="Farid K" first="Karim" last="Farid">Karim Farid</name>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5231, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5231, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sibon, Igor" sort="Sibon, Igor" uniqKey="Sibon I" first="Igor" last="Sibon">Igor Sibon</name>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5231, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5231, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guehl, Dominique" sort="Guehl, Dominique" uniqKey="Guehl D" first="Dominique" last="Guehl">Dominique Guehl</name>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5543, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5543, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cuny, Emmanuel" sort="Cuny, Emmanuel" uniqKey="Cuny E" first="Emmanuel" last="Cuny">Emmanuel Cuny</name>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5543, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5543, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burbaud, Pierre" sort="Burbaud, Pierre" uniqKey="Burbaud P" first="Pierre" last="Burbaud">Pierre Burbaud</name>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5543, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5543, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Allard, Michele" sort="Allard, Michele" uniqKey="Allard M" first="Michèle" last="Allard">Michèle Allard</name>
<affiliation wicri:level="1"><mods:affiliation>CNRS‐UMR 5231, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS‐UMR 5231, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>CHU de Bordeaux, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Université Bordeaux 2, Bordeaux, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Bordeaux 2, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Ecole Pratique des Hautes Etudes (EPHE), Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Ecole Pratique des Hautes Etudes (EPHE), Paris</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2009-10-15">2009-10-15</date>
<biblScope unit="vol">24</biblScope>
<biblScope unit="issue">13</biblScope>
<biblScope unit="page" from="1962">1962</biblScope>
<biblScope unit="page" to="1969">1969</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">0C62DB0B5BE49F52ECB956002CAA2B853993A84F</idno>
<idno type="DOI">10.1002/mds.22709</idno>
<idno type="ArticleID">MDS22709</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>dopaminergic cortical modulation</term>
<term>executive function</term>
<term>fMRI</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The progressive development of deficits in executive functions, including action planning, is a well‐known complication of Parkinson's disease. A dysfunction of the prefrontal lobe, which is known to be involved in the control of inhibitory processes, could explain the difficulties in initiating behavior or inhibiting ongoing actions in patients with PD. The strong dopaminergic innervation of the prefrontal cortex raises questions about the putative effects of dopa therapy on this cognitive impairment. In the present study, we used fMRI to examine the functional influence of dopa therapy on neural activity during a go/no‐go task in nine patients with and without levodopa treatment and in matched controls. Whereas the patient and control subjects exhibited the same performance during the go/no‐go task, different patterns of brain activation were observed depending on the dopaminergic status. The drug‐off state was characterized by more widely distributed brain activity, mainly in the bilateral caudate. Levodopa did not fully restore normal brain activation and induced changes in the pattern of cingulate cortex activity, which was more pronounced in the rostral part in the drug‐off state and in the caudal part after levodopa intake. These results support the idea of a critical role for dopamine in the control of executive functions in patients with PD. © 2009 Movement Disorder Society</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A45 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000A45 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:0C62DB0B5BE49F52ECB956002CAA2B853993A84F |texte= Brain dopaminergic modulation associated with executive function in Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |