Validation of the “L‐DOPA test” for diagnosis of restless legs syndrome
Identifieur interne : 000A43 ( Istex/Curation ); précédent : 000A42; suivant : 000A44Validation of the “L‐DOPA test” for diagnosis of restless legs syndrome
Auteurs : Karin Stiasny-Kolster [Allemagne] ; Ralf Kohnen [Allemagne] ; Jens Carsten Möller [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Wolfgang H. Oertel [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-09.
English descriptors
- KwdEn :
Abstract
We developed and validated a standardized test procedure to evaluate the accuracy of the supportive diagnostic criterion “response to dopaminergic treatment” in restless legs syndrome (RLS). Forty‐eight patients who fulfilled at least three of the four essential criteria for RLS, thus including uncertain clinical cases for a nonexpert, were recruited. Patients received a preliminary diagnosis of RLS or non‐RLS. All patients underwent a polysomnography (PSG) and were then asked to perform the diagnostic L‐DOPA test at home, which consisted in the application of one single dose of 100/25 mg L‐DOPA/benserazide and a subsequent observational period of 2 hours. Before, and in 15‐minute intervals after, drug intake, the patients rated the severity of the “symptoms in the legs” and the “urge to move the legs” using a 100‐mm visual analogue scale. Considering a 50% improvement as a positive test result, we found a sensitivity of 88% (“symptoms in the legs”) and 80% (“urge to move the legs”) with a specificity of 100% for both test items. A rate of 90% or 83% of all patients could be correctly diagnosed by the L‐DOPA test. Both scales were able to predict the response to dopaminergic agents in the subsequent course of the treatment by 100%. The periodic leg movements arousal index as assessed by polysomnography was less appropriate for the prediction of the correct diagnosis. We recommend the L‐DOPA test for diagnostic decision making in all patients with an unclear RLS diagnosis according to the essential diagnostic criteria of the International RLS Study Group. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20969
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A43
Links to Exploration step
ISTEX:5DA37515A5E9A1231E330A91AF11EF1EA4E7746BLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Validation of the “L‐DOPA test” for diagnosis of restless legs syndrome</title>
<author><name sortKey="Stiasny Olster, Karin" sort="Stiasny Olster, Karin" uniqKey="Stiasny Olster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kohnen, Ralf" sort="Kohnen, Ralf" uniqKey="Kohnen R" first="Ralf" last="Kohnen">Ralf Kohnen</name>
<affiliation wicri:level="1"><mods:affiliation>IMEREM Institute for Medical Research Management and Biometrics, Nuremberg, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>IMEREM Institute for Medical Research Management and Biometrics, Nuremberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carsten Moller, Jens" sort="Carsten Moller, Jens" uniqKey="Carsten Moller J" first="Jens" last="Carsten Möller">Jens Carsten Möller</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
<affiliation wicri:level="1"><mods:affiliation>Paracelsus Elena‐Klinik, Center of Parkinsonism and Movement Disorders, Kassel, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Paracelsus Elena‐Klinik, Center of Parkinsonism and Movement Disorders, Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:5DA37515A5E9A1231E330A91AF11EF1EA4E7746B</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1002/mds.20969</idno>
<idno type="url">https://api.istex.fr/document/5DA37515A5E9A1231E330A91AF11EF1EA4E7746B/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000A43</idno>
<idno type="wicri:Area/Istex/Curation">000A43</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Validation of the “L‐DOPA test” for diagnosis of restless legs syndrome</title>
<author><name sortKey="Stiasny Olster, Karin" sort="Stiasny Olster, Karin" uniqKey="Stiasny Olster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kohnen, Ralf" sort="Kohnen, Ralf" uniqKey="Kohnen R" first="Ralf" last="Kohnen">Ralf Kohnen</name>
<affiliation wicri:level="1"><mods:affiliation>IMEREM Institute for Medical Research Management and Biometrics, Nuremberg, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>IMEREM Institute for Medical Research Management and Biometrics, Nuremberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carsten Moller, Jens" sort="Carsten Moller, Jens" uniqKey="Carsten Moller J" first="Jens" last="Carsten Möller">Jens Carsten Möller</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
<affiliation wicri:level="1"><mods:affiliation>Paracelsus Elena‐Klinik, Center of Parkinsonism and Movement Disorders, Kassel, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Paracelsus Elena‐Klinik, Center of Parkinsonism and Movement Disorders, Kassel</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University, Marburg</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-09">2006-09</date>
<biblScope unit="vol">21</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="1333">1333</biblScope>
<biblScope unit="page" to="1339">1339</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">5DA37515A5E9A1231E330A91AF11EF1EA4E7746B</idno>
<idno type="DOI">10.1002/mds.20969</idno>
<idno type="ArticleID">MDS20969</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>L‐DOPA test</term>
<term>diagnosis</term>
<term>periodic leg movements (PLM)</term>
<term>polysomnography</term>
<term>restless legs syndrome</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We developed and validated a standardized test procedure to evaluate the accuracy of the supportive diagnostic criterion “response to dopaminergic treatment” in restless legs syndrome (RLS). Forty‐eight patients who fulfilled at least three of the four essential criteria for RLS, thus including uncertain clinical cases for a nonexpert, were recruited. Patients received a preliminary diagnosis of RLS or non‐RLS. All patients underwent a polysomnography (PSG) and were then asked to perform the diagnostic L‐DOPA test at home, which consisted in the application of one single dose of 100/25 mg L‐DOPA/benserazide and a subsequent observational period of 2 hours. Before, and in 15‐minute intervals after, drug intake, the patients rated the severity of the “symptoms in the legs” and the “urge to move the legs” using a 100‐mm visual analogue scale. Considering a 50% improvement as a positive test result, we found a sensitivity of 88% (“symptoms in the legs”) and 80% (“urge to move the legs”) with a specificity of 100% for both test items. A rate of 90% or 83% of all patients could be correctly diagnosed by the L‐DOPA test. Both scales were able to predict the response to dopaminergic agents in the subsequent course of the treatment by 100%. The periodic leg movements arousal index as assessed by polysomnography was less appropriate for the prediction of the correct diagnosis. We recommend the L‐DOPA test for diagnostic decision making in all patients with an unclear RLS diagnosis according to the essential diagnostic criteria of the International RLS Study Group. © 2006 Movement Disorder Society</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A43 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000A43 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:5DA37515A5E9A1231E330A91AF11EF1EA4E7746B |texte= Validation of the “L‐DOPA test” for diagnosis of restless legs syndrome }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |