Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery
Identifieur interne : 000917 ( Istex/Curation ); précédent : 000916; suivant : 000918Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery
Auteurs : B. Zeng [Royaume-Uni] ; Jenner [Royaume-Uni] ; C. D. Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-01.
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Abstract
In situ hybridization histochemistry was used to investigate the expression of striatal preproenkephalin and preprotachykinin messenger ribonucleic acid (mRNA) in rats with 6‐hydroxydopamine lesions of the nigrostriatal pathway followed 4 weeks later by implantation of foetal dopamine cells into the denervated striatum. Striatal dopamine deafferentation caused an (+)‐amphetamine‐induced rotational asymmetry, an increase in striatal preproenkephalin mRNA message, and a decrease in striatal preprotachykinin mRNA message relative to control animals. Two months after grafting a foetal ventral mesencephalon suspension, there was reversal of the rotational asymmetry to (+)‐amphetamine. At this time the increase in striatal preproenkephalin mRNA was significantly attenuated and the decrease in preprotachykinin mRNA was partially reversed compared to animals with a 6‐hydroxydopamine lesion alone. Subregional analysis showed the attenuation of the increase in preproenkephalin mRNA to occur in dorsolateral, dorsomedial and ventromedial, but not ventrolateral, striatal subdivisions. The partial reversal of the decreased preprotachykinin mRNA density after grafting was only statistically significant in the DM and VM subdivisions. These results demonstrate graft‐induced partial recovery of striatal function, as judged by preproenkephalin and preprotachykinin mRNA levels, within 2 months of transplantation.
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DOI: 10.1002/mds.870110109
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery</title><author><name sortKey="Zeng, B" sort="Zeng, B" uniqKey="Zeng B" first="B." last="Zeng">B. Zeng</name><affiliation wicri:level="1"><mods:affiliation>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London, U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London</wicri:regionArea></affiliation></author><author><name sortKey="Jenner" sort="Jenner" uniqKey="Jenner" last="Jenner">Jenner</name><affiliation wicri:level="1"><mods:affiliation>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London, U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London</wicri:regionArea></affiliation></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name><affiliation wicri:level="1"><mods:affiliation>University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D2770AA2280A5523BB0599F3058175A63CBBA59B</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1002/mds.870110109</idno><idno type="url">https://api.istex.fr/document/D2770AA2280A5523BB0599F3058175A63CBBA59B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000917</idno><idno type="wicri:Area/Istex/Curation">000917</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery</title><author><name sortKey="Zeng, B" sort="Zeng, B" uniqKey="Zeng B" first="B." last="Zeng">B. Zeng</name><affiliation wicri:level="1"><mods:affiliation>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London, U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London</wicri:regionArea></affiliation></author><author><name sortKey="Jenner" sort="Jenner" uniqKey="Jenner" last="Jenner">Jenner</name><affiliation wicri:level="1"><mods:affiliation>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London, U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London</wicri:regionArea></affiliation></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name><affiliation wicri:level="1"><mods:affiliation>University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1996-01">1996-01</date><biblScope unit="vol">11</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="43">43</biblScope><biblScope unit="page" to="52">52</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D2770AA2280A5523BB0599F3058175A63CBBA59B</idno><idno type="DOI">10.1002/mds.870110109</idno><idno type="ArticleID">MDS870110109</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6‐Hydroxydopamine lesion</term><term>Foetal dopamine neurone graft</term><term>Preproenkephalin messenger ribonucleic acid</term><term>Preprotachykinin messenger ribonucleic acid</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In situ hybridization histochemistry was used to investigate the expression of striatal preproenkephalin and preprotachykinin messenger ribonucleic acid (mRNA) in rats with 6‐hydroxydopamine lesions of the nigrostriatal pathway followed 4 weeks later by implantation of foetal dopamine cells into the denervated striatum. Striatal dopamine deafferentation caused an (+)‐amphetamine‐induced rotational asymmetry, an increase in striatal preproenkephalin mRNA message, and a decrease in striatal preprotachykinin mRNA message relative to control animals. Two months after grafting a foetal ventral mesencephalon suspension, there was reversal of the rotational asymmetry to (+)‐amphetamine. At this time the increase in striatal preproenkephalin mRNA was significantly attenuated and the decrease in preprotachykinin mRNA was partially reversed compared to animals with a 6‐hydroxydopamine lesion alone. Subregional analysis showed the attenuation of the increase in preproenkephalin mRNA to occur in dorsolateral, dorsomedial and ventromedial, but not ventrolateral, striatal subdivisions. The partial reversal of the decreased preprotachykinin mRNA density after grafting was only statistically significant in the DM and VM subdivisions. These results demonstrate graft‐induced partial recovery of striatal function, as judged by preproenkephalin and preprotachykinin mRNA levels, within 2 months of transplantation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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