Hyposmia in progressive supranuclear palsy
Identifieur interne : 000854 ( Istex/Curation ); précédent : 000853; suivant : 000855Hyposmia in progressive supranuclear palsy
Auteurs : Laura Silveira-Moriyama [Royaume-Uni] ; Graham Hughes [Royaume-Uni] ; Alistair Church [Royaume-Uni] ; Hilary Ayling [Royaume-Uni] ; David R. Williams [Royaume-Uni, Australie] ; Aviva Petrie [Royaume-Uni] ; Janice Holton [Royaume-Uni] ; Tamas Revesz [Royaume-Uni] ; Ann Kingsbury [Royaume-Uni] ; Huw R. Morris [Royaume-Uni] ; David J. Burn [Royaume-Uni] ; Andrew J. Lees [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
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Abstract
Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP‐P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22688
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Williams</name><affiliation wicri:level="1"><mods:affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Faculty of Medicine (Neurosciences), Monash University (Alfred Hospital Campus), Melbourne, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Faculty of Medicine (Neurosciences), Monash University (Alfred Hospital Campus), Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Petrie, Aviva" sort="Petrie, Aviva" uniqKey="Petrie A" first="Aviva" last="Petrie">Aviva Petrie</name><affiliation wicri:level="1"><mods:affiliation>Biostatistics Unit, UCL Eastman Dental Institute, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Biostatistics Unit, UCL Eastman Dental Institute, London</wicri:regionArea></affiliation></author><author><name sortKey="Holton, Janice" sort="Holton, Janice" uniqKey="Holton J" first="Janice" last="Holton">Janice Holton</name><affiliation wicri:level="1"><mods:affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Queen Square Brain Bank, UCL Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name><affiliation wicri:level="1"><mods:affiliation>Queen Square Brain Bank, UCL Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Kingsbury, Ann" sort="Kingsbury, Ann" uniqKey="Kingsbury A" first="Ann" last="Kingsbury">Ann Kingsbury</name><affiliation wicri:level="1"><mods:affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R." last="Morris">Huw R. Morris</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Cardiff University School of Medicine, Cardiff University, Cardiff, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Cardiff University School of Medicine, Cardiff University, Cardiff</wicri:regionArea></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation wicri:level="1"><mods:affiliation>Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne</wicri:regionArea></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew J. Lees</name><affiliation wicri:level="1"><mods:affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Queen Square Brain Bank, UCL Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15">2010-04-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="570">570</biblScope><biblScope unit="page" to="577">577</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F54DF7414A0B7421893A09EA4AD3745400D1D59A</idno><idno type="DOI">10.1002/mds.22688</idno><idno type="ArticleID">MDS22688</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>UPSIT</term><term>olfaction</term><term>postmortem analysis</term><term>smell</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP‐P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP. © 2010 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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