Homocysteine‐lowering therapy or antioxidant therapy for bone loss in Parkinson's disease
Identifieur interne : 000665 ( Istex/Curation ); précédent : 000664; suivant : 000666Homocysteine‐lowering therapy or antioxidant therapy for bone loss in Parkinson's disease
Auteurs : Seung Hun Lee [Corée du Sud] ; Mi Jung Kim [Corée du Sud] ; Beom-Jun Kim [Corée du Sud] ; Sung Reul Kim [Corée du Sud] ; Sail Chun [Corée du Sud] ; Jin Sook Ryu [Corée du Sud] ; Ghi Su Kim [Corée du Sud] ; Myoung Chong Lee [Corée du Sud] ; Jung-Min Koh [Corée du Sud] ; Sun Ju Chung [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
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Abstract
We investigated whether homocysteine (Hcy)‐ lowering therapy or an antioxidant prevented bone loss in Parkinson's disease (PD) patients taking levodopa. Forty‐two PD patients with low bone mineral density (BMD) taking levodopa were randomly assigned to Hcy‐lowering therapy (5 mg folate and 1500 μg vitamin B12 daily), α‐lipoic acid (α‐LA) therapy (1200 mg daily), or control groups. Primary outcomes were BMD changes from baseline to 12 months. Secondary outcomes were changes in Hcy level, and C‐telopeptide (CTX) levels at 12 months. Forty‐one patients completed the study. Hcy‐lowering therapy resulted in significantly greater BMD changes at the lumbar spine (4.4%), total femur (2.8%), and femur shaft (2.8%) than control (P = 0.005–0.023). BMD changes in the α–LA therapy group were similar to those of the control group, but changes at the trochanter (4.6%) were significantly greater in the α–LA therapy group than in the control group after adjustment for body mass index changes. Hcy concentrations decreased to 35.2% ± 13.4% in the Hcy‐lowering therapy group, but increased in other groups. Serum CTX levels at 12 months tended to be lower in the Hcy‐lowering group (0.442 ± 0.024 ng/mL) than control group (0.628 ± 0.039 ng/mL) (P = 0.159). This small trial suggests that Hcy‐lowering therapy may prevent bone loss in PD patients taking levodopa. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22866
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
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<front><div type="abstract" xml:lang="en">We investigated whether homocysteine (Hcy)‐ lowering therapy or an antioxidant prevented bone loss in Parkinson's disease (PD) patients taking levodopa. Forty‐two PD patients with low bone mineral density (BMD) taking levodopa were randomly assigned to Hcy‐lowering therapy (5 mg folate and 1500 μg vitamin B12 daily), α‐lipoic acid (α‐LA) therapy (1200 mg daily), or control groups. Primary outcomes were BMD changes from baseline to 12 months. Secondary outcomes were changes in Hcy level, and C‐telopeptide (CTX) levels at 12 months. Forty‐one patients completed the study. Hcy‐lowering therapy resulted in significantly greater BMD changes at the lumbar spine (4.4%), total femur (2.8%), and femur shaft (2.8%) than control (P = 0.005–0.023). BMD changes in the α–LA therapy group were similar to those of the control group, but changes at the trochanter (4.6%) were significantly greater in the α–LA therapy group than in the control group after adjustment for body mass index changes. Hcy concentrations decreased to 35.2% ± 13.4% in the Hcy‐lowering therapy group, but increased in other groups. Serum CTX levels at 12 months tended to be lower in the Hcy‐lowering group (0.442 ± 0.024 ng/mL) than control group (0.628 ± 0.039 ng/mL) (P = 0.159). This small trial suggests that Hcy‐lowering therapy may prevent bone loss in PD patients taking levodopa. © 2009 Movement Disorder Society</div>
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