Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study
Identifieur interne : 000331 ( Istex/Curation ); précédent : 000330; suivant : 000332Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study
Auteurs : Flavio Nobili [Italie] ; Giovanni Abbruzzese [Italie] ; Silvia Morbelli [Italie] ; Roberta Marchese [Italie] ; Nicola Girtler [Italie] ; Barbara Dessi [Italie] ; Andrea Brugnolo [Italie] ; Cinzia Canepa [Italie] ; Giorgos Chr. Drosos [Italie] ; Gianmario Sambuceti [Italie] ; Guido Rodriguez [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
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Abstract
The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22381
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Martino University Hospital, Genoa, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Drosos, Giorgos Chr" sort="Drosos, Giorgos Chr" uniqKey="Drosos G" first="Giorgos Chr." last="Drosos">Giorgos Chr. Drosos</name><affiliation wicri:level="1"><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Sambuceti, Gianmario" sort="Sambuceti, Gianmario" uniqKey="Sambuceti G" first="Gianmario" last="Sambuceti">Gianmario Sambuceti</name><affiliation wicri:level="1"><mods:affiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name><affiliation wicri:level="1"><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-02-15">2009-02-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="414">414</biblScope><biblScope unit="page" to="421">421</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8FA3710E7F523201F4933EE2C81D90BA25CD5E52</idno><idno type="DOI">10.1002/mds.22381</idno><idno type="ArticleID">MDS22381</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>amnestic mild cognitive impairment</term><term>brain SPECT, SPM</term><term>mild cognitive impairment</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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