Rate of clinical progression in Parkinson's disease. A prospective study
Identifieur interne : 000073 ( Istex/Curation ); précédent : 000072; suivant : 000074Rate of clinical progression in Parkinson's disease. A prospective study
Auteurs : Anette Schrag [Royaume-Uni] ; Richard Dodel [Allemagne] ; Annika Spottke [Allemagne] ; Bernhard Bornschein [Autriche] ; Uwe Siebert [Autriche, États-Unis] ; Niall P. Quinn [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-05-15.
English descriptors
- KwdEn :
Abstract
Few prospective data on the clinical progression of Parkinson's disease (PD) in patient groups outside treatment trials in selected patients are available, and controversy exists on the rate of clinical disease progression with advancing disease. In this study, we investigated the rate of clinical progression of PD in a clinic‐based sample of 145 patients over 1 year and in a community‐based sample of 124 patients over 4 years. Depending on the sample and clinical scale used, mean deterioration of motor and disability scores ranged from 2.4 to 7.4% of the maximum possible score per year, and standard deviations indicated that there was considerable variability of progression rates between individuals. The progression of motor scores decreased with follow‐up over 4 years and significantly decreased in more advanced disease stages. Deterioration of disability scores did not differ between disease stages; this may reflect the increasing rate of disease complications, which contribute to increasing disability in addition to motor impairment alone, in more advanced disease. Thus, motor fluctuations, hallucinations, depression, memory problems, and bladder symptoms were all reported more often at follow‐up in the community‐based sample (all P < 0.01), and dyskinesias, motor fluctuations, falls, and hallucinations were more common and cognitive and depression scores worse in higher disease stages in the clinic‐based sample (all P < 0.001). We conclude that progression of motor scores in PD decreases with advancing disease in PD. However, disability continues to deteriorate with advancing disease and with the development of disease complications that are likely to be related to additional extrastriatal pathology. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21429
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000073
Links to Exploration step
ISTEX:F1DF8109D628EB376E740F8D6552CED8CE6662B6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rate of clinical progression in Parkinson's disease. A prospective study</title><author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurosciences, Royal Free Hospital, University College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, Royal Free Hospital, University College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Spottke, Annika" sort="Spottke, Annika" uniqKey="Spottke A" first="Annika" last="Spottke">Annika Spottke</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Bornschein, Bernhard" sort="Bornschein, Bernhard" uniqKey="Bornschein B" first="Bernhard" last="Bornschein">Bernhard Bornschein</name><affiliation wicri:level="1"><mods:affiliation>UMIT University for Health Sciences, Medical Informatics and Technology, Hall, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>UMIT University for Health Sciences, Medical Informatics and Technology, Hall</wicri:regionArea></affiliation></author><author><name sortKey="Siebert, Uwe" sort="Siebert, Uwe" uniqKey="Siebert U" first="Uwe" last="Siebert">Uwe Siebert</name><affiliation wicri:level="1"><mods:affiliation>UMIT University for Health Sciences, Medical Informatics and Technology, Hall, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>UMIT University for Health Sciences, Medical Informatics and Technology, Hall</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="1"><mods:affiliation>Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F1DF8109D628EB376E740F8D6552CED8CE6662B6</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21429</idno><idno type="url">https://api.istex.fr/document/F1DF8109D628EB376E740F8D6552CED8CE6662B6/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000073</idno><idno type="wicri:Area/Istex/Curation">000073</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Rate of clinical progression in Parkinson's disease. A prospective study</title><author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurosciences, Royal Free Hospital, University College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, Royal Free Hospital, University College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Spottke, Annika" sort="Spottke, Annika" uniqKey="Spottke A" first="Annika" last="Spottke">Annika Spottke</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Bornschein, Bernhard" sort="Bornschein, Bernhard" uniqKey="Bornschein B" first="Bernhard" last="Bornschein">Bernhard Bornschein</name><affiliation wicri:level="1"><mods:affiliation>UMIT University for Health Sciences, Medical Informatics and Technology, Hall, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>UMIT University for Health Sciences, Medical Informatics and Technology, Hall</wicri:regionArea></affiliation></author><author><name sortKey="Siebert, Uwe" sort="Siebert, Uwe" uniqKey="Siebert U" first="Uwe" last="Siebert">Uwe Siebert</name><affiliation wicri:level="1"><mods:affiliation>UMIT University for Health Sciences, Medical Informatics and Technology, Hall, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>UMIT University for Health Sciences, Medical Informatics and Technology, Hall</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="1"><mods:affiliation>Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, London</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-05-15">2007-05-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="938">938</biblScope><biblScope unit="page" to="945">945</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F1DF8109D628EB376E740F8D6552CED8CE6662B6</idno><idno type="DOI">10.1002/mds.21429</idno><idno type="ArticleID">MDS21429</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>UPDRS</term><term>progression</term><term>scales</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Few prospective data on the clinical progression of Parkinson's disease (PD) in patient groups outside treatment trials in selected patients are available, and controversy exists on the rate of clinical disease progression with advancing disease. In this study, we investigated the rate of clinical progression of PD in a clinic‐based sample of 145 patients over 1 year and in a community‐based sample of 124 patients over 4 years. Depending on the sample and clinical scale used, mean deterioration of motor and disability scores ranged from 2.4 to 7.4% of the maximum possible score per year, and standard deviations indicated that there was considerable variability of progression rates between individuals. The progression of motor scores decreased with follow‐up over 4 years and significantly decreased in more advanced disease stages. Deterioration of disability scores did not differ between disease stages; this may reflect the increasing rate of disease complications, which contribute to increasing disability in addition to motor impairment alone, in more advanced disease. Thus, motor fluctuations, hallucinations, depression, memory problems, and bladder symptoms were all reported more often at follow‐up in the community‐based sample (all P < 0.01), and dyskinesias, motor fluctuations, falls, and hallucinations were more common and cognitive and depression scores worse in higher disease stages in the clinic‐based sample (all P < 0.001). We conclude that progression of motor scores in PD decreases with advancing disease in PD. However, disability continues to deteriorate with advancing disease and with the development of disease complications that are likely to be related to additional extrastriatal pathology. © 2007 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000073 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000073 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:F1DF8109D628EB376E740F8D6552CED8CE6662B6
|texte= Rate of clinical progression in Parkinson's disease. A prospective study
}}
| This area was generated with Dilib version V0.6.23. |  |