Amantadine may reverse punding in Parkinson's disease—Observation in a patient
Identifieur interne : 003C28 ( Istex/Corpus ); précédent : 003C27; suivant : 003C29Amantadine may reverse punding in Parkinson's disease—Observation in a patient
Auteurs : Kenichi Kashihara ; Takaki ImamuraSource :
- Movement Disorders [ 0885-3185 ] ; 2008-01.
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Abstract
Punding, complex stereotyped behavior, sometimes occurs in patients with Parkinson's disease under dopaminergic replacement therapy. Reduction of dopaminergic drugs may reduce the problem but risks enhancing motor impairment. We report a patient with Parkinson's disease presenting disabling punding, which was reversed by amantadine without aggravating motor function. Amantadine may reduce punding by blocking NMDA receptors, in the same manner as in levodopa‐induced dyskinesias. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21780
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Segment 2.After amantadine: She pays much less attention to the goods in her hands (pencil and roulette this time) and knees (hat). Both videos were taken at on stage.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Punding, complex stereotyped behavior, sometimes occurs in patients with Parkinson's disease under dopaminergic replacement therapy. Reduction of dopaminergic drugs may reduce the problem but risks enhancing motor impairment. We report a patient with Parkinson's disease presenting disabling punding, which was reversed by amantadine without aggravating motor function. 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Reduction of dopaminergic drugs may reduce the problem but risks enhancing motor impairment. We report a patient with Parkinson's disease presenting disabling punding, which was reversed by amantadine without aggravating motor function. Amantadine may reduce punding by blocking NMDA receptors, in the same manner as in levodopa‐induced dyskinesias. © 2007 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>amantadine</topic><topic>Parkinson's disease</topic><topic>punding</topic><topic>stereotypy</topic><topic>treatment</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> This article includes supplementary video clips, available online at http://www.interscience.wiley.com/jpages/0885‐3185/suppmatSupporting Info Item: Segment 1.Before amantadine: She makes continuous repetitive meaningless movements; checking, arranging, and polishing cups, chopsticks, trays, and things on the table. Segment 2.After amantadine: She pays much less attention to the goods in her hands (pencil and roulette this time) and knees (hat). 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