Movement Disorders (revue)

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Morphological overlap between corticobasal degeneration and Pick's disease: A clinicopathological report

Identifieur interne : 003592 ( Istex/Corpus ); précédent : 003591; suivant : 003593

Morphological overlap between corticobasal degeneration and Pick's disease: A clinicopathological report

Auteurs : Klaus Jendroska ; Martin N. Rossor ; Christopher J. Mathias ; Daniel

Source :

RBID : ISTEX:77D6458F5CE9A1B428768C963B83FF235D3A8C97

English descriptors

Abstract

An 81‐year‐old woman died after a 3‐year history of a progressive nondementing akinetic‐rigid syndrome. Initially, there was a moderate response to levodopa treatment. Subsequently she developed postural tremor, loss of upward gaze, and frequent falls suggestive of Steele‐Richardson‐Olszewski syndrome (SROS). Macroscopical examination showed depigmentation of substantia nigra and locus ceruleus. Histology revealed occasional swollen achromatic neurons predominantly in frontal cortex, small cortical neurofibrillary tangles, brain stem basophil (corticobasal) inclusions, and Pick bodies. The coexistence of these histopathological markers raises questions concerning their specificity and the basis of a morphological distinction between corticobasal degeneration and Pick's disease.

Url:
DOI: 10.1002/mds.870100118

Links to Exploration step

ISTEX:77D6458F5CE9A1B428768C963B83FF235D3A8C97

Le document en format XML

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<keyword xml:id="kwd3">Swollen neuron</keyword>
<keyword xml:id="kwd4">Pick body</keyword>
<keyword xml:id="kwd5">Basophil inclusion</keyword>
<keyword xml:id="kwd6">Neurofibrillary tangle</keyword>
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<p>An 81‐year‐old woman died after a 3‐year history of a progressive nondementing akinetic‐rigid syndrome. Initially, there was a moderate response to levodopa treatment. Subsequently she developed postural tremor, loss of upward gaze, and frequent falls suggestive of Steele‐Richardson‐Olszewski syndrome (SROS). Macroscopical examination showed depigmentation of substantia nigra and locus ceruleus. Histology revealed occasional swollen achromatic neurons predominantly in frontal cortex, small cortical neurofibrillary tangles, brain stem basophil (corticobasal) inclusions, and Pick bodies. The coexistence of these histopathological markers raises questions concerning their specificity and the basis of a morphological distinction between corticobasal degeneration and Pick's disease.</p>
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<title>Morphological overlap between corticobasal degeneration and Pick's disease: A clinicopathological report</title>
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<title>CORTICOBASAL DEGENERATION AND PICK'S DISEASE</title>
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<title>Morphological overlap between corticobasal degeneration and Pick's disease: A clinicopathological report</title>
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<name type="personal">
<namePart type="given">Klaus</namePart>
<namePart type="family">Jendroska</namePart>
<affiliation>Parkinson's Disease Society Brain Bank, London</affiliation>
<affiliation>Institute of Neurology, London</affiliation>
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<name type="personal">
<namePart type="given">Martin N.</namePart>
<namePart type="family">Rossor</namePart>
<affiliation>Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Germany</affiliation>
<affiliation>Department of Neurology, St Mary's Hospital Medical School, London, England</affiliation>
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<name type="personal">
<namePart type="given">Christopher J.</namePart>
<namePart type="family">Mathias</namePart>
<affiliation>Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Germany</affiliation>
<affiliation>Department of Neurology, St Mary's Hospital Medical School, London, England</affiliation>
<affiliation>Imperial College of Science, Technology, and Medicine, The National Hospital for Neurology and Neurosurgery, London, England</affiliation>
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<name type="personal">
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<namePart type="family">Daniel</namePart>
<affiliation>Parkinson's Disease Society Brain Bank, London</affiliation>
<affiliation>Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Germany</affiliation>
<affiliation>Department of Neuropathology, The National Hospital for Neurology and Neurosurgery, London, England</affiliation>
<description>Correspondence: Parkinson's Disease Society Brain Bank, 1 Wakefield Street, London WC1N 1PJ, England</description>
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<abstract lang="en">An 81‐year‐old woman died after a 3‐year history of a progressive nondementing akinetic‐rigid syndrome. Initially, there was a moderate response to levodopa treatment. Subsequently she developed postural tremor, loss of upward gaze, and frequent falls suggestive of Steele‐Richardson‐Olszewski syndrome (SROS). Macroscopical examination showed depigmentation of substantia nigra and locus ceruleus. Histology revealed occasional swollen achromatic neurons predominantly in frontal cortex, small cortical neurofibrillary tangles, brain stem basophil (corticobasal) inclusions, and Pick bodies. The coexistence of these histopathological markers raises questions concerning their specificity and the basis of a morphological distinction between corticobasal degeneration and Pick's disease.</abstract>
<subject lang="en">
<genre>Keywords</genre>
<topic>Corticobasal degeneration</topic>
<topic>Pick's disease</topic>
<topic>Swollen neuron</topic>
<topic>Pick body</topic>
<topic>Basophil inclusion</topic>
<topic>Neurofibrillary tangle</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
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<date>1995</date>
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<caption>vol.</caption>
<number>10</number>
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<identifier type="DOI">10.1002/mds.870100118</identifier>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 1995 Movement Disorder Society</accessCondition>
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