Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes
Identifieur interne : 003179 ( Istex/Corpus ); précédent : 003178; suivant : 003180Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes
Auteurs : Claudia Schmidt ; Birgit Herting ; Silke Prieur ; Susann Junghanns ; Katherine Schweitzer ; Christoph Globas ; Ludger Schöls ; Sabine Antoni ; Dietmar Ferger ; Heinz Reichmann ; Helmut Wilhelm ; Daniela Berg ; Tjalf ZiemssenSource :
- Movement Disorders [ 0885-3185 ] ; 2007-10-31.
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- KwdEn :
Abstract
The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21721
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<front><div type="abstract" xml:lang="en">The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society</div>
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<abstract>The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society</abstract>
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<note type="biography">C.S. and B.H. contributed equally to this work as first authors.</note>
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<note type="correspondence"><p>Correspondence: ANF Labor, Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstraβe 74, D‐01307 Dresden, Germany</p>
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<abstract lang="en">The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society</abstract>
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