Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes
Identifieur interne : 003179 ( Istex/Corpus ); précédent : 003178; suivant : 003180Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes
Auteurs : Claudia Schmidt ; Birgit Herting ; Silke Prieur ; Susann Junghanns ; Katherine Schweitzer ; Christoph Globas ; Ludger Schöls ; Sabine Antoni ; Dietmar Ferger ; Heinz Reichmann ; Helmut Wilhelm ; Daniela Berg ; Tjalf ZiemssenSource :
- Movement Disorders [ 0885-3185 ] ; 2007-10-31.
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Abstract
The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21721
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last="Prieur">Silke Prieur</name><affiliation><mods:affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name><affiliation><mods:affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Globas, Christoph" 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progressive supranuclear palsy (PSP) from other extrapyramidal syndromes</title><author><name sortKey="Schmidt, Claudia" sort="Schmidt, Claudia" uniqKey="Schmidt C" first="Claudia" last="Schmidt">Claudia Schmidt</name><affiliation><mods:affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name><affiliation><mods:affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Prieur, Silke" sort="Prieur, Silke" uniqKey="Prieur S" first="Silke" last="Prieur">Silke Prieur</name><affiliation><mods:affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name><affiliation><mods:affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Globas, Christoph" sort="Globas, Christoph" uniqKey="Globas C" first="Christoph" last="Globas">Christoph Globas</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Antoni, Sabine" sort="Antoni, Sabine" uniqKey="Antoni S" first="Sabine" last="Antoni">Sabine Antoni</name><affiliation><mods:affiliation>Department of Mathematics, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ferger, Dietmar" sort="Ferger, Dietmar" uniqKey="Ferger D" first="Dietmar" last="Ferger">Dietmar Ferger</name><affiliation><mods:affiliation>Department of Mathematics, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name><affiliation><mods:affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wilhelm, Helmut" sort="Wilhelm, Helmut" uniqKey="Wilhelm H" first="Helmut" last="Wilhelm">Helmut Wilhelm</name><affiliation><mods:affiliation>Department of Neuroophthalmology, University Eye Hospital, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name><affiliation><mods:affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-10-31">2007-10-31</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2123">2123</biblScope><biblScope unit="page" to="2126">2126</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5304C1E52C09F6DAD478A14339FA7E6016561388</idno><idno type="DOI">10.1002/mds.21721</idno><idno type="ArticleID">MDS21721</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>autonomic dysfunction</term><term>multiple system atrophy</term><term>progressive supranuclear palsy</term><term>pupil diameter in darkness</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Claudia Schmidt MD</name><affiliations><json:string>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Birgit Herting MD</name><affiliations><json:string>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Silke Prieur</name><affiliations><json:string>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Susann Junghanns MD</name><affiliations><json:string>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Katherine Schweitzer MD</name><affiliations><json:string>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Christoph Globas MD</name><affiliations><json:string>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Ludger Schöls MD</name><affiliations><json:string>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Sabine Antoni PhD</name><affiliations><json:string>Department of Mathematics, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Dietmar Ferger PhD</name><affiliations><json:string>Department of Mathematics, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Heinz Reichmann MD</name><affiliations><json:string>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Helmut Wilhelm MD</name><affiliations><json:string>Department of Neuroophthalmology, University Eye Hospital, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Daniela Berg MD</name><affiliations><json:string>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Tjalf Ziemssen MD</name><affiliations><json:string>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>progressive supranuclear palsy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pupil diameter in darkness</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autonomic dysfunction</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society</abstract><qualityIndicators><score>3.695</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>799</abstractCharCount><pdfWordCount>2447</pdfWordCount><pdfCharCount>16425</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>104</abstractWordCount></qualityIndicators><title>Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes</title><genre><json:string>Serial article</json:string></genre><host><volume>22</volume><pages><total>4</total><last>2126</last><first>2123</first></pages><issn><json:string>0885-3185</json:string></issn><issue>14</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement 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syndromes</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes</title><author><persName><forename type="first">Claudia</forename><surname>Schmidt</surname><roleName type="degree">MD</roleName></persName><note type="biography">C.S. and B.H. contributed equally to this work as first authors.</note><affiliation>C.S. and B.H. contributed equally to this work as first authors.</affiliation><affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Birgit</forename><surname>Herting</surname><roleName type="degree">MD</roleName></persName><note type="biography">C.S. and B.H. contributed equally to this work as first authors.</note><affiliation>C.S. and B.H. contributed equally to this work as first authors.</affiliation><affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Silke</forename><surname>Prieur</surname></persName><affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Susann</forename><surname>Junghanns</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Katherine</forename><surname>Schweitzer</surname><roleName type="degree">MD</roleName></persName><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</affiliation></author><author><persName><forename type="first">Christoph</forename><surname>Globas</surname><roleName type="degree">MD</roleName></persName><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</affiliation></author><author><persName><forename type="first">Ludger</forename><surname>Schöls</surname><roleName type="degree">MD</roleName></persName><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</affiliation></author><author><persName><forename type="first">Sabine</forename><surname>Antoni</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Mathematics, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Dietmar</forename><surname>Ferger</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Mathematics, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Heinz</forename><surname>Reichmann</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Helmut</forename><surname>Wilhelm</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neuroophthalmology, University Eye Hospital, Tübingen, Germany</affiliation></author><author><persName><forename type="first">Daniela</forename><surname>Berg</surname><roleName type="degree">MD</roleName></persName><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</affiliation></author><author><persName><forename type="first">Tjalf</forename><surname>Ziemssen</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: ANF Labor, Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstraβe 74, D‐01307 Dresden, Germany</p></note><affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder 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In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>progressive supranuclear palsy</term></item><item><term>pupil diameter in darkness</term></item><item><term>Parkinson's disease</term></item><item><term>multiple system atrophy</term></item><item><term>autonomic dysfunction</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-04-10">Received</change><change when="2007-08-07">Registration</change><change when="2007-10-31">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/5304C1E52C09F6DAD478A14339FA7E6016561388/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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type="manuscriptAccepted" date="2007-08-07"></event><event type="publishedOnlineEarlyUnpaginated" date="2007-09-12"></event><event type="firstOnline" date="2007-09-12"></event><event type="publishedOnlineFinalForm" date="2007-10-26"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText mathml2tex" date="2010-04-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2123</numbering><numbering type="pageLast">2126</numbering></numberingGroup><correspondenceTo>ANF Labor, Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstraβe 74, D‐01307 Dresden, Germany</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21721.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="18"></count><count type="wordTotal" number="2870"></count></countGroup><titleGroup><title type="main" xml:lang="en">Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes</title><title type="short" xml:lang="en">Pupil Diameter in Darkness</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" noteRef="#fn1"><personName><givenNames>Claudia</givenNames><familyName>Schmidt</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" noteRef="#fn1"><personName><givenNames>Birgit</givenNames><familyName>Herting</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Silke</givenNames><familyName>Prieur</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Susann</givenNames><familyName>Junghanns</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Katherine</givenNames><familyName>Schweitzer</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Christoph</givenNames><familyName>Globas</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Ludger</givenNames><familyName>Schöls</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Sabine</givenNames><familyName>Antoni</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Dietmar</givenNames><familyName>Ferger</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Heinz</givenNames><familyName>Reichmann</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Helmut</givenNames><familyName>Wilhelm</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Daniela</givenNames><familyName>Berg</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Tjalf</givenNames><familyName>Ziemssen</familyName><degrees>MD</degrees></personName><contactDetails><email>ziemssen@web.de</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>Department of Mathematics, Dresden University of Technology, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neuroophthalmology, University Eye Hospital, Tübingen, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">progressive supranuclear palsy</keyword><keyword xml:id="kwd2">pupil diameter in darkness</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">multiple system atrophy</keyword><keyword xml:id="kwd5">autonomic dysfunction</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>C.S. and B.H. contributed equally to this work as first authors.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pupil Diameter in Darkness</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes</title></titleInfo><name type="personal"><namePart type="given">Claudia</namePart><namePart type="family">Schmidt</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><description>C.S. and B.H. contributed equally to this work as first authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Birgit</namePart><namePart type="family">Herting</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><description>C.S. and B.H. contributed equally to this work as first authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Silke</namePart><namePart type="family">Prieur</namePart><affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susann</namePart><namePart type="family">Junghanns</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katherine</namePart><namePart type="family">Schweitzer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christoph</namePart><namePart type="family">Globas</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ludger</namePart><namePart type="family">Schöls</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sabine</namePart><namePart type="family">Antoni</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Mathematics, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dietmar</namePart><namePart type="family">Ferger</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Mathematics, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heinz</namePart><namePart type="family">Reichmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Movement Disorders Research Group, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helmut</namePart><namePart type="family">Wilhelm</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroophthalmology, University Eye Hospital, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniela</namePart><namePart type="family">Berg</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute of Clinical Brain Research University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tjalf</namePart><namePart type="family">Ziemssen</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Autonomic and Neuroendocrinological laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><description>Correspondence: ANF Labor, Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstraβe 74, D‐01307 Dresden, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-10-31</dateIssued><dateCaptured encoding="w3cdtf">2007-04-10</dateCaptured><dateValid encoding="w3cdtf">2007-08-07</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">18</extent><extent unit="words">2870</extent></physicalDescription><abstract lang="en">The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. © 2007 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>progressive supranuclear palsy</topic><topic>pupil diameter in darkness</topic><topic>Parkinson's disease</topic><topic>multiple system atrophy</topic><topic>autonomic dysfunction</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2123</start><end>2126</end><total>4</total></extent></part></relatedItem><identifier type="istex">5304C1E52C09F6DAD478A14339FA7E6016561388</identifier><identifier type="DOI">10.1002/mds.21721</identifier><identifier type="ArticleID">MDS21721</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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