Antero‐ventral internal pallidum stimulation improves behavioral disorders in Lesch–Nyhan disease
Identifieur interne : 003170 ( Istex/Corpus ); précédent : 003169; suivant : 003171Antero‐ventral internal pallidum stimulation improves behavioral disorders in Lesch–Nyhan disease
Auteurs : Laura Cif ; Brigitte Biolsi ; Sophie Gavarini ; Aude Saux ; Santiago Gil Robles ; Cornel Tancu ; Xavier Vasques ; Philippe CoubesSource :
- Movement Disorders [ 0885-3185 ] ; 2007-10-31.
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Abstract
The Lesch–Nyhan syndrome is an X‐linked recessive disorder caused by a deficiency in hypoxanthine–guanine phosphoribosyl transferase, a purine salvage enzyme. Affected individuals exhibit a characteristic neurobehavioral disorder with delayed acquisition of motor skills, dystonia, severe self‐mutilations, and aggressive behavior. Deep brain stimulation has been previously proposed for controlling isolated involuntary movements and psychiatric disorders. We applied a double bilateral simultaneous stimulation to limbic and motor internal pallidum in one patient for controlling both behavioral and movement disorders, respectively. The injurious compulsions disappeared; dystonia and dyskinesia were decreased at 28 months follow‐up. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21723
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ISTEX:FAB3446595192B831E717048AC9CE33BB3E6A43ALe document en format XML
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Affected individuals exhibit a characteristic neurobehavioral disorder with delayed acquisition of motor skills, dystonia, severe self‐mutilations, and aggressive behavior. Deep brain stimulation has been previously proposed for controlling isolated involuntary movements and psychiatric disorders. We applied a double bilateral simultaneous stimulation to limbic and motor internal pallidum in one patient for controlling both behavioral and movement disorders, respectively. The injurious compulsions disappeared; dystonia and dyskinesia were decreased at 28 months follow‐up. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Laura Cif MD, MSc</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</json:string></affiliations></json:item><json:item><name>Brigitte Biolsi MD</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string></affiliations></json:item><json:item><name>Sophie Gavarini PhD</name><affiliations><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</json:string></affiliations></json:item><json:item><name>Aude Saux BSc</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string></affiliations></json:item><json:item><name>Santiago Gil Robles MD, MSc</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>INSERM, U661, Montpellier, France</json:string></affiliations></json:item><json:item><name>Cornel Tancu MD, MSc</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</json:string></affiliations></json:item><json:item><name>Xavier Vasques MSc</name><affiliations><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</json:string></affiliations></json:item><json:item><name>Philippe Coubes MD, PhD</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Lesch–Nyhan disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>self injury</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dystonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>internal pallidum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DBS</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The Lesch–Nyhan syndrome is an X‐linked recessive disorder caused by a deficiency in hypoxanthine–guanine phosphoribosyl transferase, a purine salvage enzyme. 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type="figureTotal" number="2"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="14"></count><count type="wordTotal" number="2222"></count></countGroup><titleGroup><title type="main" xml:lang="en">Antero‐ventral internal pallidum stimulation improves behavioral disorders in Lesch–Nyhan disease</title><title type="short" xml:lang="en">DBS for Self‐Injury and Dystonia in LND</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Laura</givenNames><familyName>Cif</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Brigitte</givenNames><familyName>Biolsi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Sophie</givenNames><familyName>Gavarini</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Aude</givenNames><familyName>Saux</familyName><degrees>BSc</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Santiago Gil</givenNames><familyName>Robles</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Cornel</givenNames><familyName>Tancu</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Xavier</givenNames><familyName>Vasques</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af2 #af3" corresponding="yes"><personName><givenNames>Philippe</givenNames><familyName>Coubes</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email normalForm="p-coubes@chu-montpellier.fr">p‐coubes@chu‐montpellier.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>INSERM, U661, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Lesch–Nyhan disease</keyword><keyword xml:id="kwd2">self injury</keyword><keyword xml:id="kwd3">dystonia</keyword><keyword xml:id="kwd4">internal pallidum</keyword><keyword xml:id="kwd5">DBS</keyword></keywordGroup><supportingInformation><p> This article includes supplementary video clips, available online at <url href="http://www.interscience.wiley.com/jpages/0885-3185/suppmat"> http://www.interscience.wiley.com/jpages/0885‐3185/suppmat </url></p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds21723:mds21723-MDS21723"></mediaResource><caption>First sequence. Patient before surgery in his ordinary environment. Several items of the BPI‐1 (Behavior Problem Inventory) are positive. Self‐mutilation behavior with severe lip biting and lip amputation. The hands are protected by gloves and permanently tied to the bed. Aggressive behavior against his environment with kicking/hitting his father. The patient is cruel with his mother during the breakfast. He is spitting the food on his mother.Second sequence. After surgery in the hospital. At rest, the four limbs are not tied to the bed and to the wheelchair, and protection of the fingers by the gloves is not necessary anymore. Bilateral simple manipulations are possible.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The Lesch–Nyhan syndrome is an X‐linked recessive disorder caused by a deficiency in hypoxanthine–guanine phosphoribosyl transferase, a purine salvage enzyme. Affected individuals exhibit a characteristic neurobehavioral disorder with delayed acquisition of motor skills, dystonia, severe self‐mutilations, and aggressive behavior. Deep brain stimulation has been previously proposed for controlling isolated involuntary movements and psychiatric disorders. We applied a double bilateral simultaneous stimulation to limbic and motor internal pallidum in one patient for controlling both behavioral and movement disorders, respectively. The injurious compulsions disappeared; dystonia and dyskinesia were decreased at 28 months follow‐up. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Antero‐ventral internal pallidum stimulation improves behavioral disorders in Lesch–Nyhan disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DBS for Self‐Injury and Dystonia in LND</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Antero‐ventral internal pallidum stimulation improves behavioral disorders in Lesch–Nyhan disease</title></titleInfo><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Cif</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brigitte</namePart><namePart type="family">Biolsi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sophie</namePart><namePart type="family">Gavarini</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aude</namePart><namePart type="family">Saux</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Santiago Gil</namePart><namePart type="family">Robles</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cornel</namePart><namePart type="family">Tancu</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xavier</namePart><namePart type="family">Vasques</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Coubes</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier I, CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation><description>Correspondence: CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-10-31</dateIssued><dateCaptured encoding="w3cdtf">2007-04-03</dateCaptured><dateValid encoding="w3cdtf">2007-08-07</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="references">14</extent><extent unit="words">2222</extent></physicalDescription><abstract lang="en">The Lesch–Nyhan syndrome is an X‐linked recessive disorder caused by a deficiency in hypoxanthine–guanine phosphoribosyl transferase, a purine salvage enzyme. Affected individuals exhibit a characteristic neurobehavioral disorder with delayed acquisition of motor skills, dystonia, severe self‐mutilations, and aggressive behavior. Deep brain stimulation has been previously proposed for controlling isolated involuntary movements and psychiatric disorders. We applied a double bilateral simultaneous stimulation to limbic and motor internal pallidum in one patient for controlling both behavioral and movement disorders, respectively. The injurious compulsions disappeared; dystonia and dyskinesia were decreased at 28 months follow‐up. © 2007 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Lesch–Nyhan disease</topic><topic>self injury</topic><topic>dystonia</topic><topic>internal pallidum</topic><topic>DBS</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> This article includes supplementary video clips, available online at http://www.interscience.wiley.com/jpages/0885‐3185/suppmatSupporting Info Item: First sequence. Patient before surgery in his ordinary environment. Several items of the BPI‐1 (Behavior Problem Inventory) are positive. Self‐mutilation behavior with severe lip biting and lip amputation. The hands are protected by gloves and permanently tied to the bed. Aggressive behavior against his environment with kicking/hitting his father. The patient is cruel with his mother during the breakfast. He is spitting the food on his mother.Second sequence. After surgery in the hospital. At rest, the four limbs are not tied to the bed and to the wheelchair, and protection of the fingers by the gloves is not necessary anymore. Bilateral simple manipulations are possible. - </note><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2126</start><end>2129</end><total>4</total></extent></part></relatedItem><identifier type="istex">FAB3446595192B831E717048AC9CE33BB3E6A43A</identifier><identifier type="DOI">10.1002/mds.21723</identifier><identifier type="ArticleID">MDS21723</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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