Severe evening dyskinesias in advanced Parkinson's disease: Clinical description, relation to plasma levodopa, and treatment
Identifieur interne : 003151 ( Istex/Corpus ); précédent : 003150; suivant : 003152Severe evening dyskinesias in advanced Parkinson's disease: Clinical description, relation to plasma levodopa, and treatment
Auteurs : Thomas R. Zimmerman Jr. ; Jacob I. Sage ; Anthony E. Lang ; MarkSource :
- Movement Disorders [ 0885-3185 ] ; 1994.
English descriptors
Abstract
We report four patients with Parkinson's disease who had an unusual pattern of severe chorea and dystonia in the evenings only. The temporal pattern of abnormal movements and simultaneous monitoring of plasma levodopa and clinical state were consistent with dyskinesias associated with subtherapeutic (low dopa dyskinesias) rather than peak concentrations of levodopa (high dopa dyskinesias). In two patients, addition of a direct‐acting dopamine receptor agonist was helpful in ameliorating this complication of anitparkinson therapy.
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DOI: 10.1002/mds.870090208
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994">1994</date><biblScope unit="vol">9</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="173">173</biblScope><biblScope unit="page" to="177">177</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">13157136085C969EE4830BC362C6C00615ACB2B4</idno><idno type="DOI">10.1002/mds.870090208</idno><idno type="ArticleID">MDS870090208</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dyskinesias</term><term>Evening</term><term>Low dopa dyskinesias</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report four patients with Parkinson's disease who had an unusual pattern of severe chorea and dystonia in the evenings only. The temporal pattern of abnormal movements and simultaneous monitoring of plasma levodopa and clinical state were consistent with dyskinesias associated with subtherapeutic (low dopa dyskinesias) rather than peak concentrations of levodopa (high dopa dyskinesias). In two patients, addition of a direct‐acting dopamine receptor agonist was helpful in ameliorating this complication of anitparkinson therapy.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Thomas R. Zimmerman Jr.</name><affiliations><json:string>Department of Neurology, University of Medicine and Dentistry of New Jersey‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, U.S.A.</json:string></affiliations></json:item><json:item><name>Jacob I. Sage</name><affiliations><json:string>Department of Neurology, University of Medicine and Dentistry of New Jersey‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, U.S.A.</json:string></affiliations></json:item><json:item><name>Anthony E. Lang</name><affiliations><json:string>Division of Neurology and the Playfair Neurosciences Unit, University of Toronto, The Toronto Hospital, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Dr. Mark</name><affiliations><json:string>Department of Neurology, University of Medicine and Dentistry of New Jersey‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, U.S.A.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Evening</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dyskinesias</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Low dopa dyskinesias</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We report four patients with Parkinson's disease who had an unusual pattern of severe chorea and dystonia in the evenings only. 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The temporal pattern of abnormal movements and simultaneous monitoring of plasma levodopa and clinical state were consistent with dyskinesias associated with subtherapeutic (low dopa dyskinesias) rather than peak concentrations of levodopa (high dopa dyskinesias). In two patients, addition of a direct‐acting dopamine receptor agonist was helpful in ameliorating this complication of anitparkinson therapy.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Severe evening dyskinesias in advanced Parkinson's disease: Clinical description, relation to plasma levodopa, and treatment</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SEVERE EVENING DYSKINESIAS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Severe evening dyskinesias in advanced Parkinson's disease: Clinical description, relation to plasma levodopa, and treatment</title></titleInfo><name type="personal"><namePart type="given">Thomas R.</namePart><namePart type="family">Zimmerman Jr.</namePart><affiliation>Department of Neurology, University of Medicine and Dentistry of New Jersey‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jacob I.</namePart><namePart type="family">Sage</namePart><affiliation>Department of Neurology, University of Medicine and Dentistry of New Jersey‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony E.</namePart><namePart type="family">Lang</namePart><affiliation>Division of Neurology and the Playfair Neurosciences Unit, University of Toronto, The Toronto Hospital, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Mark</namePart><affiliation>Department of Neurology, University of Medicine and Dentistry of New Jersey‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, U.S.A.</affiliation><description>Correspondence: Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, CN‐19, New Brunswick, NJ 08903, U.S.A.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="references">12</extent></physicalDescription><abstract lang="en">We report four patients with Parkinson's disease who had an unusual pattern of severe chorea and dystonia in the evenings only. The temporal pattern of abnormal movements and simultaneous monitoring of plasma levodopa and clinical state were consistent with dyskinesias associated with subtherapeutic (low dopa dyskinesias) rather than peak concentrations of levodopa (high dopa dyskinesias). In two patients, addition of a direct‐acting dopamine receptor agonist was helpful in ameliorating this complication of anitparkinson therapy.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Evening</topic><topic>Dyskinesias</topic><topic>Low dopa dyskinesias</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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