123I‐Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism
Identifieur interne : 002E32 ( Istex/Corpus ); précédent : 002E31; suivant : 002E33123I‐Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism
Auteurs : Carles Gaig ; Maria José Martí ; Eduardo Tolosa ; Francesc Valldeoriola ; Pilar Paredes ; Francisco Juan Lome A ; Fernando NakamaeSource :
- Movement Disorders [ 0885-3185 ] ; 2006-11.
English descriptors
Abstract
Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed 123I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, 123I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, 123I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21062
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ISTEX:8963D2E53E502495B9D3CBAFC4500CD431C96CA0Le document en format XML
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Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed 123I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, 123I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, 123I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Carles Gaig MD</name><affiliations><json:string>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Maria José Martí MD, PhD</name><affiliations><json:string>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Eduardo Tolosa MD, PhD</name><affiliations><json:string>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Francesc Valldeoriola MD, PhD</name><affiliations><json:string>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Pilar Paredes MD</name><affiliations><json:string>Nuclear Medicine Service, Hospital Clínic, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Francisco Juan Lomeña MD, PhD</name><affiliations><json:string>Nuclear Medicine Service, Hospital Clínic, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Fernando Nakamae MD</name><affiliations><json:string>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>psychogenic Parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>123I‐Ioflupane SPECT</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DAT imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parkin gene mutation</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed 123I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, 123I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, 123I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. 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We performed 123I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, 123I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, 123I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome. © 2006 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>psychogenic Parkinsonism</term></item><item><term>123I‐Ioflupane SPECT</term></item><item><term>DAT imaging</term></item><item><term>parkin gene mutation</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-11-18">Received</change><change when="2006-04-15">Registration</change><change when="2006-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8963D2E53E502495B9D3CBAFC4500CD431C96CA0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed <sup>123</sup>I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, <sup>123</sup>I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a <i>parkin</i> gene mutation was detected. In the other 8 patients, <sup>123</sup>I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>123I‐Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>123I‐Ioflupane SPECT and PsyP</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>I‐Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism</title></titleInfo><name type="personal"><namePart type="given">Carles</namePart><namePart type="family">Gaig</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria José</namePart><namePart type="family">Martí</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</affiliation><description>Correspondence: Hospital Clínic, Service of Neurology. Villarroel 170, Barcelona 08036, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduardo</namePart><namePart type="family">Tolosa</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesc</namePart><namePart type="family">Valldeoriola</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pilar</namePart><namePart type="family">Paredes</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Nuclear Medicine Service, Hospital Clínic, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francisco Juan</namePart><namePart type="family">Lomeña</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Nuclear Medicine Service, Hospital Clínic, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fernando</namePart><namePart type="family">Nakamae</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2006-11</dateIssued><dateCaptured encoding="w3cdtf">2005-11-18</dateCaptured><dateValid encoding="w3cdtf">2006-04-15</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">15</extent><extent unit="words">3045</extent></physicalDescription><abstract lang="en">Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed 123I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, 123I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, 123I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome. © 2006 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>psychogenic Parkinsonism</topic><topic>123I‐Ioflupane SPECT</topic><topic>DAT imaging</topic><topic>parkin gene mutation</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1994</start><end>1998</end><total>4</total></extent></part></relatedItem><identifier type="istex">8963D2E53E502495B9D3CBAFC4500CD431C96CA0</identifier><identifier type="DOI">10.1002/mds.21062</identifier><identifier type="ArticleID">MDS21062</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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