Spastic paraplegia 15: Linkage and clinical description of three Tunisian families
Identifieur interne : 002E27 ( Istex/Corpus ); précédent : 002E26; suivant : 002E28Spastic paraplegia 15: Linkage and clinical description of three Tunisian families
Auteurs : Amir Boukhris ; Imed Feki ; Elodie Denis ; Mohamed Imed Miladi ; Alexis Brice ; Chokri Mhiri ; Giovanni StevaninSource :
- Movement Disorders [ 0885-3185 ] ; 2008-02-15.
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Abstract
Hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity of the lower limbs. The locus designated spastic paraplegia 15 (SPG15), located in a 16‐Mb interval on chromosome 14q, is associated with a rare autosomal recessive complicated form of HSP known as Kjellin's syndrome. In this study, we describe three additional families, of Tunisian origin, linked to the SPG15 locus, one of which had a significant multipoint LOD score of 3.46. In accordance with previous reports, the phenotype of our patients consisted of early onset spastic paraparesis associated with mental impairment and severe progression. Retinal degeneration was not observed, however, but we extended the phenotype of this form to include peripheral neuropathy and white matter abnormalities on MRI. Interestingly, like retinal degeneration, thin corpus callosum is not a constant feature in this entity. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21848
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Brice</name><affiliation><mods:affiliation>INSERM, U679, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Mhiri, Chokri" sort="Mhiri, Chokri" uniqKey="Mhiri C" first="Chokri" last="Mhiri">Chokri Mhiri</name><affiliation><mods:affiliation>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</mods:affiliation></affiliation><affiliation><mods:affiliation>Faculté de Médecine de Sfax, Tunisia</mods:affiliation></affiliation></author><author><name sortKey="Stevanin, Giovanni" sort="Stevanin, Giovanni" uniqKey="Stevanin G" first="Giovanni" last="Stevanin">Giovanni 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The locus designated spastic paraplegia 15 (SPG15), located in a 16‐Mb interval on chromosome 14q, is associated with a rare autosomal recessive complicated form of HSP known as Kjellin's syndrome. In this study, we describe three additional families, of Tunisian origin, linked to the SPG15 locus, one of which had a significant multipoint LOD score of 3.46. In accordance with previous reports, the phenotype of our patients consisted of early onset spastic paraparesis associated with mental impairment and severe progression. Retinal degeneration was not observed, however, but we extended the phenotype of this form to include peripheral neuropathy and white matter abnormalities on MRI. Interestingly, like retinal degeneration, thin corpus callosum is not a constant feature in this entity. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Amir Boukhris MD</name><affiliations><json:string>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</json:string><json:string>Faculté de Médecine de Sfax, Tunisia</json:string><json:string>INSERM, U679, Paris, France</json:string><json:string>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</json:string><json:string>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</json:string></affiliations></json:item><json:item><name>Imed Feki MD</name><affiliations><json:string>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</json:string><json:string>Faculté de Médecine de Sfax, Tunisia</json:string></affiliations></json:item><json:item><name>Elodie Denis BS</name><affiliations><json:string>INSERM, U679, Paris, France</json:string><json:string>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</json:string><json:string>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</json:string></affiliations></json:item><json:item><name>Mohamed Imed Miladi MD</name><affiliations><json:string>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</json:string><json:string>Faculté de Médecine de Sfax, Tunisia</json:string></affiliations></json:item><json:item><name>Alexis Brice MD</name><affiliations><json:string>INSERM, U679, Paris, France</json:string><json:string>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</json:string><json:string>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</json:string></affiliations></json:item><json:item><name>Chokri Mhiri MD</name><affiliations><json:string>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</json:string><json:string>Faculté de Médecine de Sfax, Tunisia</json:string></affiliations></json:item><json:item><name>Giovanni Stevanin PhD</name><affiliations><json:string>INSERM, U679, Paris, France</json:string><json:string>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</json:string><json:string>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>hereditary spastic paraplegia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Kjellin's syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SPG15</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>linkage</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>14q22–q24</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>thin corpus callosum</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity of the lower limbs. The locus designated spastic paraplegia 15 (SPG15), located in a 16‐Mb interval on chromosome 14q, is associated with a rare autosomal recessive complicated form of HSP known as Kjellin's syndrome. In this study, we describe three additional families, of Tunisian origin, linked to the SPG15 locus, one of which had a significant multipoint LOD score of 3.46. In accordance with previous reports, the phenotype of our patients consisted of early onset spastic paraparesis associated with mental impairment and severe progression. Retinal degeneration was not observed, however, but we extended the phenotype of this form to include peripheral neuropathy and white matter abnormalities on MRI. 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Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</affiliation><affiliation>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</affiliation></author><author><persName><forename type="first">Mohamed Imed</forename><surname>Miladi</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</affiliation><affiliation>Faculté de Médecine de Sfax, Tunisia</affiliation></author><author><persName><forename type="first">Alexis</forename><surname>Brice</surname><roleName type="degree">MD</roleName></persName><affiliation>INSERM, U679, Paris, France</affiliation><affiliation>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</affiliation><affiliation>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, 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Interestingly, like retinal degeneration, thin corpus callosum is not a constant feature in this entity. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>hereditary spastic paraplegia</term></item><item><term>Kjellin's syndrome</term></item><item><term>SPG15</term></item><item><term>linkage</term></item><item><term>14q22–q24</term></item><item><term>thin corpus callosum</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-07-23">Received</change><change when="2007-10-17">Registration</change><change when="2008-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/5B8D511B4C6488A3015F71A76CF6B3FE5712BAED/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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date="2007-10-17"></event><event type="publishedOnlineEarlyUnpaginated" date="2007-12-20"></event><event type="firstOnline" date="2007-12-20"></event><event type="publishedOnlineFinalForm" date="2008-02-25"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">429</numbering><numbering type="pageLast">433</numbering></numberingGroup><correspondenceTo>INSERM U679, Groupe Pitié‐Salpêtrière, 47 Bd de l'Hôpital, 75013 Paris, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21848.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="15"></count><count type="wordTotal" number="2881"></count></countGroup><titleGroup><title type="main" xml:lang="en">Spastic paraplegia 15: Linkage and clinical description of three Tunisian families</title><title type="short" xml:lang="en">SPG15 in Tunisia</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4 #af5"><personName><givenNames>Amir</givenNames><familyName>Boukhris</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Imed</givenNames><familyName>Feki</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3 #af4 #af5"><personName><givenNames>Elodie</givenNames><familyName>Denis</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Mohamed Imed</givenNames><familyName>Miladi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3 #af4 #af5"><personName><givenNames>Alexis</givenNames><familyName>Brice</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Chokri</givenNames><familyName>Mhiri</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3 #af4 #af5" corresponding="yes"><personName><givenNames>Giovanni</givenNames><familyName>Stevanin</familyName><degrees>PhD</degrees></personName><contactDetails><email>stevanin@ccr.jussieu.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="TN" type="organization"><unparsedAffiliation>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="TN" type="organization"><unparsedAffiliation>Faculté de Médecine de Sfax, Tunisia</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>INSERM, U679, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">hereditary spastic paraplegia</keyword><keyword xml:id="kwd2">Kjellin's syndrome</keyword><keyword xml:id="kwd3"><i>SPG15</i></keyword><keyword xml:id="kwd4">linkage</keyword><keyword xml:id="kwd5">14q22–q24</keyword><keyword xml:id="kwd6">thin <i>corpus callosum</i></keyword></keywordGroup><fundingInfo><fundingAgency>French Tunisian cooperation project led by INSERM (France)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>DGRST (Tunisia)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>VERUM Foundation (Germany)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>French National Agency for Research (ANR)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Fellowship from the Association Strümpell‐Lorrain (ASL, France)</fundingAgency></fundingInfo><supportingInformation><p> This article contains supplementary material available via the Internet at <url href="http://www.interscience.wiley.com/jpages/0885-3185/suppmat"> http://www.interscience.wiley.com/jpages/0885‐3185/suppmat </url> . </p></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity of the lower limbs. The locus designated <i>spastic paraplegia 15</i> (<i>SPG15</i>), located in a 16‐Mb interval on chromosome 14q, is associated with a rare autosomal recessive complicated form of HSP known as Kjellin's syndrome. In this study, we describe three additional families, of Tunisian origin, linked to the <i>SPG15</i> locus, one of which had a significant multipoint LOD score of 3.46. In accordance with previous reports, the phenotype of our patients consisted of early onset spastic paraparesis associated with mental impairment and severe progression. Retinal degeneration was not observed, however, but we extended the phenotype of this form to include peripheral neuropathy and white matter abnormalities on MRI. Interestingly, like retinal degeneration, thin <i>corpus callosum</i> is not a constant feature in this entity. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Spastic paraplegia 15: Linkage and clinical description of three Tunisian families</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SPG15 in Tunisia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Spastic paraplegia 15: Linkage and clinical description of three Tunisian families</title></titleInfo><name type="personal"><namePart type="given">Amir</namePart><namePart type="family">Boukhris</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</affiliation><affiliation>Faculté de Médecine de Sfax, Tunisia</affiliation><affiliation>INSERM, U679, Paris, France</affiliation><affiliation>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</affiliation><affiliation>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Imed</namePart><namePart type="family">Feki</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</affiliation><affiliation>Faculté de Médecine de Sfax, Tunisia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elodie</namePart><namePart type="family">Denis</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>INSERM, U679, Paris, France</affiliation><affiliation>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</affiliation><affiliation>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mohamed Imed</namePart><namePart type="family">Miladi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</affiliation><affiliation>Faculté de Médecine de Sfax, Tunisia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Brice</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM, U679, Paris, France</affiliation><affiliation>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</affiliation><affiliation>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chokri</namePart><namePart type="family">Mhiri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Habib Bourguiba University Hospital, Sfax, Tunisia</affiliation><affiliation>Faculté de Médecine de Sfax, Tunisia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Stevanin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, U679, Paris, France</affiliation><affiliation>Pierre and Marie Curie – Paris 6 University, UMR S679, Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</affiliation><affiliation>Department of Genetics and Cytogenetics, Pitié‐Salpêtrière Hospital, AP‐HP, Paris, France</affiliation><description>Correspondence: INSERM U679, Groupe Pitié‐Salpêtrière, 47 Bd de l'Hôpital, 75013 Paris, France</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-02-15</dateIssued><dateCaptured encoding="w3cdtf">2007-07-23</dateCaptured><dateValid encoding="w3cdtf">2007-10-17</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">15</extent><extent unit="words">2881</extent></physicalDescription><abstract lang="en">Hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity of the lower limbs. The locus designated spastic paraplegia 15 (SPG15), located in a 16‐Mb interval on chromosome 14q, is associated with a rare autosomal recessive complicated form of HSP known as Kjellin's syndrome. In this study, we describe three additional families, of Tunisian origin, linked to the SPG15 locus, one of which had a significant multipoint LOD score of 3.46. In accordance with previous reports, the phenotype of our patients consisted of early onset spastic paraparesis associated with mental impairment and severe progression. Retinal degeneration was not observed, however, but we extended the phenotype of this form to include peripheral neuropathy and white matter abnormalities on MRI. Interestingly, like retinal degeneration, thin corpus callosum is not a constant feature in this entity. © 2007 Movement Disorder Society</abstract><note type="funding">French Tunisian cooperation project led by INSERM (France)</note><note type="funding">DGRST (Tunisia)</note><note type="funding">VERUM Foundation (Germany)</note><note type="funding">French National Agency for Research (ANR)</note><note type="funding">Fellowship from the Association Strümpell‐Lorrain (ASL, France)</note><subject lang="en"><genre>Keywords</genre><topic>hereditary spastic paraplegia</topic><topic>Kjellin's syndrome</topic><topic>SPG15</topic><topic>linkage</topic><topic>14q22–q24</topic><topic>thin corpus callosum</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> This article contains supplementary material available via the Internet at http://www.interscience.wiley.com/jpages/0885‐3185/suppmat .</note><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>429</start><end>433</end><total>5</total></extent></part></relatedItem><identifier type="istex">5B8D511B4C6488A3015F71A76CF6B3FE5712BAED</identifier><identifier type="DOI">10.1002/mds.21848</identifier><identifier type="ArticleID">MDS21848</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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