Movement Disorders (revue)

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Pallidal stimulation reduces treatment‐induced dyskinesias in “minimal‐change” multiple system atrophy

Identifieur interne : 002D80 ( Istex/Corpus ); précédent : 002D79; suivant : 002D81

Pallidal stimulation reduces treatment‐induced dyskinesias in “minimal‐change” multiple system atrophy

Auteurs : Yue Huang ; Raymond Garrick ; Raymond Cook ; Dudley O'Sullivan ; John Morris ; Glenda M. Halliday

Source :

RBID : ISTEX:D56C0EEF15814A21388B1354ED437B2F41703AA9

English descriptors

Abstract

Deep brain stimulation therapy is increasingly gaining acceptance in the management of levodopa‐induced dyskinesia and fluctuations in idiopathic Parkinson's disease. It is generally not recommended for the other forms of parkinsonism such as progressive supranuclear palsy or multiple system atrophy where the response to levodopa is usually poor and disease progression more rapid, making any benefit short‐lived. Here, we present an autopsy‐confirmed case of “minimal‐change” multiple system atrophy in whom pallidal stimulation surgery was effective in abolishing severe levodopa‐induced dyskinesia. © 2005 Movement Disorder Society

Url:
DOI: 10.1002/mds.20497

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ISTEX:D56C0EEF15814A21388B1354ED437B2F41703AA9

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<caption> Segment 1. A 47‐year‐old woman's prominent bradykinesia and rigidity are shown. There is no tremor. Her most rigid facial expression is not particularly "mask‐like," and ocular movements are normal. She has prominent action‐induced twitches of her fingers, suggestive of cortical myoclonus. Segment 2. The patient's dyskinesia is observed after the administration of Sinemet 100/25 totalling 1,500 mg of L‐dopa daily. Segment 3. Two weeks later after pallidal surgery for deep brain stimulation implantation and still takingL ‐dopa medication, her mobility and general well‐being are greatly improved. No other medications were taken during this period. This video presentation has been abbreviated. The full version will appear on theMovementDisorders DVD Supplement, which is issued bi‐annually. </caption>
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<p>Deep brain stimulation therapy is increasingly gaining acceptance in the management of levodopa‐induced dyskinesia and fluctuations in idiopathic Parkinson's disease. It is generally not recommended for the other forms of parkinsonism such as progressive supranuclear palsy or multiple system atrophy where the response to levodopa is usually poor and disease progression more rapid, making any benefit short‐lived. Here, we present an autopsy‐confirmed case of “minimal‐change” multiple system atrophy in whom pallidal stimulation surgery was effective in abolishing severe levodopa‐induced dyskinesia. © 2005 Movement Disorder Society</p>
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<abstract lang="en">Deep brain stimulation therapy is increasingly gaining acceptance in the management of levodopa‐induced dyskinesia and fluctuations in idiopathic Parkinson's disease. It is generally not recommended for the other forms of parkinsonism such as progressive supranuclear palsy or multiple system atrophy where the response to levodopa is usually poor and disease progression more rapid, making any benefit short‐lived. Here, we present an autopsy‐confirmed case of “minimal‐change” multiple system atrophy in whom pallidal stimulation surgery was effective in abolishing severe levodopa‐induced dyskinesia. © 2005 Movement Disorder Society</abstract>
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<note type="content"> This article includes Supplementary Video, available online at http://www.interscience.wiley.com/jpages/0885‐3185/suppmatSupporting Info Item: Segment 1. A 47‐year‐old woman's prominent bradykinesia and rigidity are shown. There is no tremor. Her most rigid facial expression is not particularly "mask‐like," and ocular movements are normal. She has prominent action‐induced twitches of her fingers, suggestive of cortical myoclonus. Segment 2. The patient's dyskinesia is observed after the administration of Sinemet 100/25 totalling 1,500 mg of L‐dopa daily. Segment 3. Two weeks later after pallidal surgery for deep brain stimulation implantation and still takingL ‐dopa medication, her mobility and general well‐being are greatly improved. No other medications were taken during this period. This video presentation has been abbreviated. The full version will appear on theMovementDisorders DVD Supplement, which is issued bi‐annually. - </note>
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<date>2005</date>
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