Dopamine transporter SPECT: How to remove subjectivity?
Identifieur interne : 002D61 ( Istex/Corpus ); précédent : 002D60; suivant : 002D62Dopamine transporter SPECT: How to remove subjectivity?
Auteurs : Christoph Scherfler ; Michael NockerSource :
- Movement Disorders [ 0885-3185 ] ; 2009.
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Abstract
Clinical criteria enable accurate and reliable diagnosis of parkinsonian syndromes when cardinal clinical features are fully developed. Single photon emission computed tomography (SPECT) investigating the striatal dopamine transporter (DAT) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug‐induced, vascular and psychogenetic parkinsonism. Several approaches for the analysis of the striatal DAT distribution have been tested for their ability to analyze and quantify SPECT images. Visual assessment of DAT binding and semiquantitative analysis using region of interests have been recommended by Nuclear Medicine Associations to be incorporated in the routine work‐up of DAT‐SPECT. Besides these observer dependent approaches, fully automated image‐analysis techniques have been validated in the clinical setting. Their potential as tools to improve the diagnostic accuracy in patients presenting with parkinsonian features is reviewed here. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22590
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ISTEX:48A575F25D3BAAD7B6239C1895719686B5FCC93ALe document en format XML
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Single photon emission computed tomography (SPECT) investigating the striatal dopamine transporter (DAT) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug‐induced, vascular and psychogenetic parkinsonism. Several approaches for the analysis of the striatal DAT distribution have been tested for their ability to analyze and quantify SPECT images. Visual assessment of DAT binding and semiquantitative analysis using region of interests have been recommended by Nuclear Medicine Associations to be incorporated in the routine work‐up of DAT‐SPECT. Besides these observer dependent approaches, fully automated image‐analysis techniques have been validated in the clinical setting. Their potential as tools to improve the diagnostic accuracy in patients presenting with parkinsonian features is reviewed here. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Christoph Scherfler MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Michael Nocker MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>SPECT</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopamine transporter</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subjectivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>operator‐independent</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>visual rating</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>region of interest</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Clinical criteria enable accurate and reliable diagnosis of parkinsonian syndromes when cardinal clinical features are fully developed. 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Single photon emission computed tomography (SPECT) investigating the striatal dopamine transporter (DAT) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug‐induced, vascular and psychogenetic parkinsonism. Several approaches for the analysis of the striatal DAT distribution have been tested for their ability to analyze and quantify SPECT images. Visual assessment of DAT binding and semiquantitative analysis using region of interests have been recommended by Nuclear Medicine Associations to be incorporated in the routine work‐up of DAT‐SPECT. Besides these observer dependent approaches, fully automated image‐analysis techniques have been validated in the clinical setting. Their potential as tools to improve the diagnostic accuracy in patients presenting with parkinsonian features is reviewed here. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>SPECT</topic><topic>dopamine transporter</topic><topic>subjectivity</topic><topic>operator‐independent</topic><topic>visual rating</topic><topic>region of interest</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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