Striatal gray matter loss in Huntington's disease is leftward biased
Identifieur interne : 002D55 ( Istex/Corpus ); précédent : 002D54; suivant : 002D56Striatal gray matter loss in Huntington's disease is leftward biased
Auteurs : Mark Mühlau ; Christian Gaser ; Afra M. Wohlschl Ger ; Adolf Weindl ; Michael St Dtler ; Michael Valet ; Claus Zimmer ; Jan Kassubek ; Alexander PeinemannSource :
- Movement Disorders [ 0885-3185 ] ; 2007-06-15.
English descriptors
Abstract
In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21137
Links to Exploration step
ISTEX:B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Striatal gray matter loss in Huntington's disease is leftward biased</title><author><name sortKey="Muhlau, Mark" sort="Muhlau, Mark" uniqKey="Muhlau M" first="Mark" last="Mühlau">Mark Mühlau</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gaser, Christian" sort="Gaser, Christian" uniqKey="Gaser C" first="Christian" last="Gaser">Christian Gaser</name><affiliation><mods:affiliation>Department of Psychiatry, University of Jena, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wohlschl Ger, Afra M" sort="Wohlschl Ger, Afra M" uniqKey="Wohlschl Ger A" first="Afra M." last="Wohlschl Ger">Afra M. Wohlschl Ger</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Nuclear Medicine, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="St Dtler, Michael" sort="St Dtler, Michael" uniqKey="St Dtler M" first="Michael" last="St Dtler">Michael St Dtler</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Valet, Michael" sort="Valet, Michael" uniqKey="Valet M" first="Michael" last="Valet">Michael Valet</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name><affiliation><mods:affiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Peinemann, Alexander" sort="Peinemann, Alexander" uniqKey="Peinemann A" first="Alexander" last="Peinemann">Alexander Peinemann</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21137</idno><idno type="url">https://api.istex.fr/document/B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002D55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Striatal gray matter loss in Huntington's disease is leftward biased</title><author><name sortKey="Muhlau, Mark" sort="Muhlau, Mark" uniqKey="Muhlau M" first="Mark" last="Mühlau">Mark Mühlau</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gaser, Christian" sort="Gaser, Christian" uniqKey="Gaser C" first="Christian" last="Gaser">Christian Gaser</name><affiliation><mods:affiliation>Department of Psychiatry, University of Jena, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wohlschl Ger, Afra M" sort="Wohlschl Ger, Afra M" uniqKey="Wohlschl Ger A" first="Afra M." last="Wohlschl Ger">Afra M. Wohlschl Ger</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Nuclear Medicine, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="St Dtler, Michael" sort="St Dtler, Michael" uniqKey="St Dtler M" first="Michael" last="St Dtler">Michael St Dtler</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Valet, Michael" sort="Valet, Michael" uniqKey="Valet M" first="Michael" last="Valet">Michael Valet</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name><affiliation><mods:affiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Peinemann, Alexander" sort="Peinemann, Alexander" uniqKey="Peinemann A" first="Alexander" last="Peinemann">Alexander Peinemann</name><affiliation><mods:affiliation>Department of Neurology, Technische Universität München, Munich, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-06-15">2007-06-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1169">1169</biblScope><biblScope unit="page" to="1173">1173</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9</idno><idno type="DOI">10.1002/mds.21137</idno><idno type="ArticleID">MDS21137</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term><term>gray matter loss</term><term>lateralization, striatum</term><term>voxel‐based morphometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Mark Mühlau MD</name><affiliations><json:string>Department of Neurology, Technische Universität München, Munich, Germany</json:string></affiliations></json:item><json:item><name>Christian Gaser PhD</name><affiliations><json:string>Department of Psychiatry, University of Jena, Jena, Germany</json:string></affiliations></json:item><json:item><name>Afra M. Wohlschläger PhD</name><affiliations><json:string>Department of Neurology, Technische Universität München, Munich, Germany</json:string><json:string>Department of Neuroradiology, Technische Universität München, Munich, Germany</json:string><json:string>Department of Nuclear Medicine, Technische Universität München, Munich, Germany</json:string></affiliations></json:item><json:item><name>Adolf Weindl MD</name><affiliations><json:string>Department of Neurology, Technische Universität München, Munich, Germany</json:string></affiliations></json:item><json:item><name>Michael Städtler</name><affiliations><json:string>Department of Neurology, Technische Universität München, Munich, Germany</json:string></affiliations></json:item><json:item><name>Michael Valet MD</name><affiliations><json:string>Department of Neurology, Technische Universität München, Munich, Germany</json:string></affiliations></json:item><json:item><name>Claus Zimmer MD</name><affiliations><json:string>Department of Neuroradiology, Technische Universität München, Munich, Germany</json:string></affiliations></json:item><json:item><name>Jan Kassubek MD</name><affiliations><json:string>Department of Neurology, University of Ulm, Ulm, Germany</json:string></affiliations></json:item><json:item><name>Alexander Peinemann MD</name><affiliations><json:string>Department of Neurology, Technische Universität München, Munich, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>gray matter loss</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Huntington's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>lateralization, striatum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>voxel‐based morphometry</value></json:item></subject><language><json:string>eng</json:string></language><abstract>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society</abstract><qualityIndicators><score>4.34</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>764</abstractCharCount><pdfWordCount>2996</pdfWordCount><pdfCharCount>19381</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>112</abstractWordCount></qualityIndicators><title>Striatal gray matter loss in Huntington's disease is leftward biased</title><genre><json:string>Serial article</json:string></genre><host><volume>22</volume><pages><total>5</total><last>1173</last><first>1169</first></pages><issn><json:string>0885-3185</json:string></issn><issue>8</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/mds.21137</json:string></doi><id>B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Striatal gray matter loss in Huntington's disease is leftward biased</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Striatal gray matter loss in Huntington's disease is leftward biased</title><author><persName><forename type="first">Mark</forename><surname>Mühlau</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Technische Universität München, Department of Neurology, Möhlstrasse 28, D‐81675 München, Germany</p></note><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation></author><author><persName><forename type="first">Christian</forename><surname>Gaser</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Psychiatry, University of Jena, Jena, Germany</affiliation></author><author><persName><forename type="first">Afra M.</forename><surname>Wohlschläger</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation><affiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</affiliation><affiliation>Department of Nuclear Medicine, Technische Universität München, Munich, Germany</affiliation></author><author><persName><forename type="first">Adolf</forename><surname>Weindl</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Städtler</surname></persName><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Valet</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation></author><author><persName><forename type="first">Claus</forename><surname>Zimmer</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</affiliation></author><author><persName><forename type="first">Jan</forename><surname>Kassubek</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation></author><author><persName><forename type="first">Alexander</forename><surname>Peinemann</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-06-15"></date><biblScope unit="vol">22</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1169">1169</biblScope><biblScope unit="page" to="1173">1173</biblScope></imprint></monogr><idno type="istex">B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9</idno><idno type="DOI">10.1002/mds.21137</idno><idno type="ArticleID">MDS21137</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>gray matter loss</term></item><item><term>Huntington's disease</term></item><item><term>lateralization, striatum</term></item><item><term>voxel‐based morphometry</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-03-02">Received</change><change when="2006-06-26">Registration</change><change when="2007-06-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="80"><doi origin="wiley" registered="yes">10.1002/mds.v22:8</doi><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue">8</numbering></numberingGroup><coverDate startDate="2007-06-15">15 June 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="170" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21137</doi><idGroup><id type="unit" value="MDS21137"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2007 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2006-03-02"></event><event type="manuscriptRevised" date="2006-06-26"></event><event type="manuscriptAccepted" date="2006-06-26"></event><event type="firstOnline" date="2007-03-29"></event><event type="publishedOnlineFinalForm" date="2007-06-19"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2007-03-29"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1169</numbering><numbering type="pageLast">1173</numbering></numberingGroup><correspondenceTo>Technische Universität München, Department of Neurology, Möhlstrasse 28, D‐81675 München, Germany</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21137.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="15"></count><count type="wordTotal" number="3130"></count></countGroup><titleGroup><title type="main" xml:lang="en">Striatal gray matter loss in Huntington's disease is leftward biased</title><title type="short" xml:lang="en">Striatal Gray Matter Loss in HD is Leftward Biased</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Mark</givenNames><familyName>Mühlau</familyName><degrees>MD</degrees></personName><contactDetails><email>m.muehlau@neuro.med.tum.de</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Christian</givenNames><familyName>Gaser</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af3 #af4"><personName><givenNames>Afra M.</givenNames><familyName>Wohlschläger</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Adolf</givenNames><familyName>Weindl</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michael</givenNames><familyName>Städtler</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michael</givenNames><familyName>Valet</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Claus</givenNames><familyName>Zimmer</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Jan</givenNames><familyName>Kassubek</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alexander</givenNames><familyName>Peinemann</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Technische Universität München, Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Department of Psychiatry, University of Jena, Jena, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>Department of Nuclear Medicine, Technische Universität München, Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University of Ulm, Ulm, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">gray matter loss</keyword><keyword xml:id="kwd2">Huntington's disease</keyword><keyword xml:id="kwd3">lateralization, striatum</keyword><keyword xml:id="kwd4">voxel‐based morphometry</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Striatal gray matter loss in Huntington's disease is leftward biased</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Striatal Gray Matter Loss in HD is Leftward Biased</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Striatal gray matter loss in Huntington's disease is leftward biased</title></titleInfo><name type="personal"><namePart type="given">Mark</namePart><namePart type="family">Mühlau</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation><description>Correspondence: Technische Universität München, Department of Neurology, Möhlstrasse 28, D‐81675 München, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christian</namePart><namePart type="family">Gaser</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychiatry, University of Jena, Jena, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Afra M.</namePart><namePart type="family">Wohlschläger</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation><affiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</affiliation><affiliation>Department of Nuclear Medicine, Technische Universität München, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adolf</namePart><namePart type="family">Weindl</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Städtler</namePart><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Valet</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claus</namePart><namePart type="family">Zimmer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroradiology, Technische Universität München, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Kassubek</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexander</namePart><namePart type="family">Peinemann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technische Universität München, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-06-15</dateIssued><dateCaptured encoding="w3cdtf">2006-03-02</dateCaptured><dateValid encoding="w3cdtf">2006-06-26</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">15</extent><extent unit="words">3130</extent></physicalDescription><abstract lang="en">In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>gray matter loss</topic><topic>Huntington's disease</topic><topic>lateralization, striatum</topic><topic>voxel‐based morphometry</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1169</start><end>1173</end><total>5</total></extent></part></relatedItem><identifier type="istex">B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9</identifier><identifier type="DOI">10.1002/mds.21137</identifier><identifier type="ArticleID">MDS21137</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D55 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002D55 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9
|texte= Striatal gray matter loss in Huntington's disease is leftward biased
}}
| This area was generated with Dilib version V0.6.23. |  |