Pathologic gambling in Parkinson's disease: A behavioral manifestation of pharmacologic treatment?
Identifieur interne : 002C44 ( Istex/Corpus ); précédent : 002C43; suivant : 002C45Pathologic gambling in Parkinson's disease: A behavioral manifestation of pharmacologic treatment?
Auteurs : José Antonio Molina ; María José Sáinz-Artiga ; Alicia Fraile ; Félix Javier Jiménez-Jiménez ; Clara Villanueva ; Miguel Ortí-Pareja ; Félix Bermejo-PSource :
- Movement Disorders [ 0885-3185 ] ; 2000-09.
English descriptors
Abstract
We describe 12 patients with Parkinson's disease and pathologic gambling. This association has apparently never been reported. The patients were selected from a Parkinson's disease unit of 250 patients. They met Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for pathologic gambling. All patients underwent a neurologic, psychiatric, and psychologic examination, specifically noting the presence or absence of psychopathology in the spectrum of impulse control disorder and the nature of the gambling. Ten patients started gambling after the onset of Parkinson's disease and treatment with levodopa. The pathologic behavior was exclusively present or was markedly increased in “on” periods in 11 patients. All patients had motor fluctuations at the time of the study. Slot machines were the preferred source of gambling for 10 patients, similar to the Spanish gambling population. That the gambling behavior appears more often in the “on” periods of motor fluctuations and that it begins after the onset of Parkinson's disease in most patients and worsens with levodopa therapy suggest that it could be related to the dopaminergic tone in patients with Parkinson's disease and motor fluctuations (that is, it could represent a behavioral manifestation of pharmacologic treatment).
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DOI: 10.1002/1531-8257(200009)15:5<869::AID-MDS1016>3.0.CO;2-I
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Spain</mods:affiliation></affiliation></author><author><name sortKey="Jimenez Imenez, Felix Javier" sort="Jimenez Imenez, Felix Javier" uniqKey="Jimenez Imenez F" first="Félix Javier" last="Jiménez-Jiménez">Félix Javier Jiménez-Jiménez</name><affiliation><mods:affiliation>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Villanueva, Clara" sort="Villanueva, Clara" uniqKey="Villanueva C" first="Clara" last="Villanueva">Clara Villanueva</name><affiliation><mods:affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Orti Areja, Miguel" sort="Orti Areja, Miguel" uniqKey="Orti Areja M" first="Miguel" last="Ortí-Pareja">Miguel Ortí-Pareja</name><affiliation><mods:affiliation>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Bermejo, Felix" sort="Bermejo, Felix" uniqKey="Bermejo F" first="Félix" last="Bermejo-P">Félix Bermejo-P</name><affiliation><mods:affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-09">2000-09</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="869">869</biblScope><biblScope unit="page" to="872">872</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D2441E26F52B69FC5FE05EE9815A10F6DF81A66B</idno><idno type="DOI">10.1002/1531-8257(200009)15:5<869::AID-MDS1016>3.0.CO;2-I</idno><idno type="ArticleID">MDS1016</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Impulse control disorders</term><term>Movement disorders</term><term>Parkinson's disease</term><term>Pathologic gambling</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We describe 12 patients with Parkinson's disease and pathologic gambling. This association has apparently never been reported. The patients were selected from a Parkinson's disease unit of 250 patients. They met Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for pathologic gambling. All patients underwent a neurologic, psychiatric, and psychologic examination, specifically noting the presence or absence of psychopathology in the spectrum of impulse control disorder and the nature of the gambling. Ten patients started gambling after the onset of Parkinson's disease and treatment with levodopa. The pathologic behavior was exclusively present or was markedly increased in “on” periods in 11 patients. All patients had motor fluctuations at the time of the study. Slot machines were the preferred source of gambling for 10 patients, similar to the Spanish gambling population. That the gambling behavior appears more often in the “on” periods of motor fluctuations and that it begins after the onset of Parkinson's disease in most patients and worsens with levodopa therapy suggest that it could be related to the dopaminergic tone in patients with Parkinson's disease and motor fluctuations (that is, it could represent a behavioral manifestation of pharmacologic treatment).</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>José Antonio Molina MD, PhD</name><affiliations><json:string>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</json:string></affiliations></json:item><json:item><name>María José Sáinz‐Artiga</name><affiliations><json:string>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Alicia Fraile MD</name><affiliations><json:string>Department of Psychiatry, Hospital Universitario Doce de Octubre, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Félix Javier Jiménez‐Jiménez MD, PhD</name><affiliations><json:string>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Clara Villanueva</name><affiliations><json:string>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Miguel Ortí‐Pareja MD, PhD</name><affiliations><json:string>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Félix Bermejo‐P MD, PhD</name><affiliations><json:string>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Impulse control disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Movement disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pathologic gambling</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We describe 12 patients with Parkinson's disease and pathologic gambling. This association has apparently never been reported. The patients were selected from a Parkinson's disease unit of 250 patients. They met Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for pathologic gambling. All patients underwent a neurologic, psychiatric, and psychologic examination, specifically noting the presence or absence of psychopathology in the spectrum of impulse control disorder and the nature of the gambling. Ten patients started gambling after the onset of Parkinson's disease and treatment with levodopa. The pathologic behavior was exclusively present or was markedly increased in “on” periods in 11 patients. All patients had motor fluctuations at the time of the study. Slot machines were the preferred source of gambling for 10 patients, similar to the Spanish gambling population. That the gambling behavior appears more often in the “on” periods of motor fluctuations and that it begins after the onset of Parkinson's disease in most patients and worsens with levodopa therapy suggest that it could be related to the dopaminergic tone in patients with Parkinson's disease and motor fluctuations (that is, it could represent a behavioral manifestation of pharmacologic treatment).</abstract><qualityIndicators><score>4.472</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1310</abstractCharCount><pdfWordCount>2156</pdfWordCount><pdfCharCount>14564</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>193</abstractWordCount></qualityIndicators><title>Pathologic gambling in Parkinson's disease: A behavioral manifestation of pharmacologic treatment?</title><genre><json:string>Serial article</json:string></genre><host><volume>15</volume><pages><total>4</total><last>872</last><first>869</first></pages><issn><json:string>0885-3185</json:string></issn><issue>5</issue><subject><json:item><value>Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1002/1531-8257(200009)15:5>869::AID-MDS1016>3.0.CO;2-I</json:string></doi><id>D2441E26F52B69FC5FE05EE9815A10F6DF81A66B</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/D2441E26F52B69FC5FE05EE9815A10F6DF81A66B/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/D2441E26F52B69FC5FE05EE9815A10F6DF81A66B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D2441E26F52B69FC5FE05EE9815A10F6DF81A66B/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Pathologic gambling in Parkinson's disease: A behavioral manifestation of pharmacologic treatment?</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><availability><p>John Wiley & Sons, Inc.</p></availability><date>2000</date></publicationStmt><notesStmt><note>Comunidad de Madrid and Fundacion Neurociencias y Envejecimiento - No. 08.5/005/97;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Pathologic gambling in Parkinson's disease: A behavioral manifestation of pharmacologic treatment?</title><author><persName><forename type="first">José Antonio</forename><surname>Molina</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation></author><author><persName><forename type="first">María José</forename><surname>Sáinz‐Artiga</surname></persName><affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation></author><author><persName><forename type="first">Alicia</forename><surname>Fraile</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Psychiatry, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation></author><author><persName><forename type="first">Félix Javier</forename><surname>Jiménez‐Jiménez</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: C/ Corregidor Jose de Pasamont 24, 3° D, E‐8030 Madrid, Spain</p></note><affiliation>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</affiliation></author><author><persName><forename type="first">Clara</forename><surname>Villanueva</surname></persName><affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation></author><author><persName><forename type="first">Miguel</forename><surname>Ortí‐Pareja</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</affiliation></author><author><persName><forename type="first">Félix</forename><surname>Bermejo‐P</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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That the gambling behavior appears more often in the “on” periods of motor fluctuations and that it begins after the onset of Parkinson's disease in most patients and worsens with levodopa therapy suggest that it could be related to the dopaminergic tone in patients with Parkinson's disease and motor fluctuations (that is, it could represent a behavioral manifestation of pharmacologic treatment).</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Impulse control disorders</term></item><item><term>Movement disorders</term></item><item><term>Parkinson's disease</term></item><item><term>Pathologic gambling</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-12-15">Received</change><change when="2000-03-15">Registration</change><change when="2000-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D2441E26F52B69FC5FE05EE9815A10F6DF81A66B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/1531-8257(200009)15:5<>1.0.CO;2-S</doi><numberingGroup><numbering type="journalVolume" number="15">15</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2000-09">September 2000</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="16" status="forIssue"><doi origin="wiley" registered="yes">10.1002/1531-8257(200009)15:5<869::AID-MDS1016>3.0.CO;2-I</doi><idGroup><id type="unit" value="MDS1016"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2000 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="1999-12-15"></event><event type="manuscriptAccepted" date="2000-03-15"></event><event type="firstOnline" date="2001-01-23"></event><event type="publishedOnlineFinalForm" date="2001-01-23"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.18.1 mode:FullText source:HeaderRef result:HeaderRef" date="2010-09-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">869</numbering><numbering type="pageLast">872</numbering></numberingGroup><correspondenceTo>C/ Corregidor Jose de Pasamont 24, 3° D, E‐8030 Madrid, Spain</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS1016.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="25"></count><count type="wordTotal" number="2073"></count></countGroup><titleGroup><title type="main" xml:lang="en">Pathologic gambling in Parkinson's disease: A behavioral manifestation of pharmacologic treatment?</title><title type="short" xml:lang="en">Pathologic Gambling and PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>José Antonio</givenNames><familyName>Molina</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>María José</givenNames><familyName>Sáinz‐Artiga</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Alicia</givenNames><familyName>Fraile</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3" corresponding="yes"><personName><givenNames>Félix Javier</givenNames><familyName>Jiménez‐Jiménez</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Clara</givenNames><familyName>Villanueva</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Miguel</givenNames><familyName>Ortí‐Pareja</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Félix</givenNames><familyName>Bermejo‐P</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="ES" type="organization"><unparsedAffiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="ES" type="organization"><unparsedAffiliation>Department of Psychiatry, Hospital Universitario Doce de Octubre, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="ES" type="organization"><unparsedAffiliation>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Impulse control disorders</keyword><keyword xml:id="kwd2">Movement disorders</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">Pathologic gambling</keyword></keywordGroup><fundingInfo><fundingAgency>Comunidad de Madrid and Fundacion Neurociencias y Envejecimiento</fundingAgency><fundingNumber>08.5/005/97</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We describe 12 patients with Parkinson's disease and pathologic gambling. This association has apparently never been reported. The patients were selected from a Parkinson's disease unit of 250 patients. They met <i>Diagnostic and Statistical Manual of Mental Disorders</i>, 4th edition, criteria for pathologic gambling. All patients underwent a neurologic, psychiatric, and psychologic examination, specifically noting the presence or absence of psychopathology in the spectrum of impulse control disorder and the nature of the gambling. Ten patients started gambling after the onset of Parkinson's disease and treatment with levodopa. The pathologic behavior was exclusively present or was markedly increased in “on” periods in 11 patients. All patients had motor fluctuations at the time of the study. Slot machines were the preferred source of gambling for 10 patients, similar to the Spanish gambling population. That the gambling behavior appears more often in the “on” periods of motor fluctuations and that it begins after the onset of Parkinson's disease in most patients and worsens with levodopa therapy suggest that it could be related to the dopaminergic tone in patients with Parkinson's disease and motor fluctuations (that is, it could represent a behavioral manifestation of pharmacologic treatment).</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Pathologic gambling in Parkinson's disease: A behavioral manifestation of pharmacologic treatment?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pathologic Gambling and PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Pathologic gambling in Parkinson's disease: A behavioral manifestation of pharmacologic treatment?</title></titleInfo><name type="personal"><namePart type="given">José Antonio</namePart><namePart type="family">Molina</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">María José</namePart><namePart type="family">Sáinz‐Artiga</namePart><affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alicia</namePart><namePart type="family">Fraile</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Psychiatry, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Félix Javier</namePart><namePart type="family">Jiménez‐Jiménez</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</affiliation><description>Correspondence: C/ Corregidor Jose de Pasamont 24, 3° D, E‐8030 Madrid, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clara</namePart><namePart type="family">Villanueva</namePart><affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miguel</namePart><namePart type="family">Ortí‐Pareja</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Medicine–Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Félix</namePart><namePart type="family">Bermejo‐P</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2000-09</dateIssued><dateCaptured encoding="w3cdtf">1999-12-15</dateCaptured><dateValid encoding="w3cdtf">2000-03-15</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">25</extent><extent unit="words">2073</extent></physicalDescription><abstract lang="en">We describe 12 patients with Parkinson's disease and pathologic gambling. This association has apparently never been reported. The patients were selected from a Parkinson's disease unit of 250 patients. They met Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for pathologic gambling. All patients underwent a neurologic, psychiatric, and psychologic examination, specifically noting the presence or absence of psychopathology in the spectrum of impulse control disorder and the nature of the gambling. Ten patients started gambling after the onset of Parkinson's disease and treatment with levodopa. The pathologic behavior was exclusively present or was markedly increased in “on” periods in 11 patients. All patients had motor fluctuations at the time of the study. Slot machines were the preferred source of gambling for 10 patients, similar to the Spanish gambling population. That the gambling behavior appears more often in the “on” periods of motor fluctuations and that it begins after the onset of Parkinson's disease in most patients and worsens with levodopa therapy suggest that it could be related to the dopaminergic tone in patients with Parkinson's disease and motor fluctuations (that is, it could represent a behavioral manifestation of pharmacologic treatment).</abstract><note type="funding">Comunidad de Madrid and Fundacion Neurociencias y Envejecimiento - No. 08.5/005/97; </note><subject lang="en"><genre>Keywords</genre><topic>Impulse control disorders</topic><topic>Movement disorders</topic><topic>Parkinson's disease</topic><topic>Pathologic gambling</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>869</start><end>872</end><total>4</total></extent></part></relatedItem><identifier type="istex">D2441E26F52B69FC5FE05EE9815A10F6DF81A66B</identifier><identifier type="DOI">10.1002/1531-8257(200009)15:5<869::AID-MDS1016>3.0.CO;2-I</identifier><identifier type="ArticleID">MDS1016</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2000 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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