Movement Disorders (revue)

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Olfaction in essential tremor patients with and without isolated rest tremor

Identifieur interne : 002B24 ( Istex/Corpus ); précédent : 002B23; suivant : 002B25

Olfaction in essential tremor patients with and without isolated rest tremor

Auteurs : Elan D. Louis ; Eva C. Jurewicz

Source :

RBID : ISTEX:DB3AF488EEBEFF4BB0353D3343353BB21FD6927F

English descriptors

Abstract

An olfactory deficit is present in patients with essential tremor (ET), but it is often milder than that in patients with Parkinson's disease (PD). In both, the deficit occurs early in the disease. Isolated rest tremor without other signs of parkinsonism can occur in patients with ET. If the rest tremor in these patients represents a manifestation of ET rather than early PD, we hypothesized that their University of Pennsylvania Smell Identification Test (UPSIT) scores would be similar to those of ET patients without rest tremor. The mean UPSIT score in 13 ET patients with isolated rest tremor did not differ from that of 58 ET patients without rest tremor (29.3 ± 4.3 vs. 29.4 ± 6.4; P = 0.69). Several ET patients with rest tremor had UPSIT scores that fell outside of the range that is seen in 95% of patients with PD. These data raise the possibility that some ET patients with isolated rest tremor may not have early PD and that the pathological process that is responsible for their ET is also involving the basal ganglia. © 2003 Movement Disorder Society

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DOI: 10.1002/mds.10603

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ISTEX:DB3AF488EEBEFF4BB0353D3343353BB21FD6927F

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<abstract lang="fr">An olfactory deficit is present in patients with essential tremor (ET), but it is often milder than that in patients with Parkinson's disease (PD). In both, the deficit occurs early in the disease. Isolated rest tremor without other signs of parkinsonism can occur in patients with ET. If the rest tremor in these patients represents a manifestation of ET rather than early PD, we hypothesized that their University of Pennsylvania Smell Identification Test (UPSIT) scores would be similar to those of ET patients without rest tremor. The mean UPSIT score in 13 ET patients with isolated rest tremor did not differ from that of 58 ET patients without rest tremor (29.3 ± 4.3 vs. 29.4 ± 6.4; P = 0.69). Several ET patients with rest tremor had UPSIT scores that fell outside of the range that is seen in 95% of patients with PD. These data raise the possibility that some ET patients with isolated rest tremor may not have early PD and that the pathological process that is responsible for their ET is also involving the basal ganglia. © 2003 Movement Disorder Society</abstract>
<note type="funding">National Institutes of Health General Clinical Research Center - No. R01 NS39422; No. RR00645; </note>
<subject lang="en">
<genre>Keywords</genre>
<topic>essential tremor</topic>
<topic>olfaction</topic>
<topic>rest tremor</topic>
<topic>Parkinson's disease</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
</titleInfo>
<titleInfo type="abbreviated">
<title>Mov. Disord.</title>
</titleInfo>
<subject>
<genre>article category</genre>
<topic>Clinical/Scientific Note</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>2003</date>
<detail type="volume">
<caption>vol.</caption>
<number>18</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>11</number>
</detail>
<extent unit="pages">
<start>1387</start>
<end>1389</end>
<total>3</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">DB3AF488EEBEFF4BB0353D3343353BB21FD6927F</identifier>
<identifier type="DOI">10.1002/mds.10603</identifier>
<identifier type="ArticleID">MDS10603</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorder Society</accessCondition>
<recordInfo>
<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
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