Paroxysmal dyskinesias in mice
Identifieur interne : 002958 ( Istex/Corpus ); précédent : 002957; suivant : 002959Paroxysmal dyskinesias in mice
Auteurs : Thomas L. Shirley ; Lekha M. Rao ; Ellen J. Hess ; H. A. JinnahSource :
- Movement Disorders [ 0885-3185 ] ; 2008-01-30.
English descriptors
- KwdEn :
Abstract
Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21829
Links to Exploration step
ISTEX:BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Paroxysmal dyskinesias in mice</title>
<author><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L." last="Shirley">Thomas L. Shirley</name>
<affiliation><mods:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Rao, Lekha M" sort="Rao, Lekha M" uniqKey="Rao L" first="Lekha M." last="Rao">Lekha M. Rao</name>
<affiliation><mods:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation><mods:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation><mods:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21829</idno>
<idno type="url">https://api.istex.fr/document/BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002958</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Paroxysmal dyskinesias in mice</title>
<author><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L." last="Shirley">Thomas L. Shirley</name>
<affiliation><mods:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Rao, Lekha M" sort="Rao, Lekha M" uniqKey="Rao L" first="Lekha M." last="Rao">Lekha M. Rao</name>
<affiliation><mods:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation><mods:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation><mods:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-01-30">2008-01-30</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="259">259</biblScope>
<biblScope unit="page" to="264">264</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5</idno>
<idno type="DOI">10.1002/mds.21829</idno>
<idno type="ArticleID">MDS21829</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>channelopathy</term>
<term>dystonia</term>
<term>lethargic</term>
<term>paroxysmal dyskinesia</term>
<term>rocker</term>
<term>tottering</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<istex><corpusName>wiley</corpusName>
<author><json:item><name>Thomas L. Shirley PhD</name>
<affiliations><json:string>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</json:string>
</affiliations>
</json:item>
<json:item><name>Lekha M. Rao MD</name>
<affiliations><json:string>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</json:string>
</affiliations>
</json:item>
<json:item><name>Ellen J. Hess PhD</name>
<affiliations><json:string>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</json:string>
</affiliations>
</json:item>
<json:item><name>H. A. Jinnah MD, PhD</name>
<affiliations><json:string>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</json:string>
</affiliations>
</json:item>
</author>
<subject><json:item><lang><json:string>eng</json:string>
</lang>
<value>tottering</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>lethargic</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>rocker</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>paroxysmal dyskinesia</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>dystonia</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>channelopathy</value>
</json:item>
</subject>
<language><json:string>eng</json:string>
</language>
<abstract>Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society</abstract>
<qualityIndicators><score>4.912</score>
<pdfVersion>1.3</pdfVersion>
<pdfPageSize>594 x 792 pts</pdfPageSize>
<refBibsNative>true</refBibsNative>
<abstractCharCount>835</abstractCharCount>
<pdfWordCount>3568</pdfWordCount>
<pdfCharCount>22650</pdfCharCount>
<pdfPageCount>6</pdfPageCount>
<abstractWordCount>112</abstractWordCount>
</qualityIndicators>
<title>Paroxysmal dyskinesias in mice</title>
<genre><json:string>Serial article</json:string>
</genre>
<host><volume>23</volume>
<pages><total>6</total>
<last>264</last>
<first>259</first>
</pages>
<issn><json:string>0885-3185</json:string>
</issn>
<issue>2</issue>
<subject><json:item><value>Research Article</value>
</json:item>
</subject>
<genre></genre>
<language><json:string>unknown</json:string>
</language>
<title>Movement Disorders</title>
<doi><json:string>10.1002/(ISSN)1531-8257</json:string>
</doi>
</host>
<publicationDate>2008</publicationDate>
<copyrightDate>2008</copyrightDate>
<doi><json:string>10.1002/mds.21829</json:string>
</doi>
<id>BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5</id>
<fulltext><json:item><original>true</original>
<mimetype>application/pdf</mimetype>
<extension>pdf</extension>
<uri>https://api.istex.fr/document/BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5/fulltext/pdf</uri>
</json:item>
<json:item><original>false</original>
<mimetype>application/zip</mimetype>
<extension>zip</extension>
<uri>https://api.istex.fr/document/BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5/fulltext/zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/document/BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Paroxysmal dyskinesias in mice</title>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<availability><p>Wiley Subscription Services, Inc., A Wiley Company</p>
</availability>
<date>2008</date>
</publicationStmt>
<notesStmt><note>NIH - No. F32 NS52040; No. R01 NS40470; No. R01 NS33592;</note>
<note>Bachmann‐Strauss Dystonia & Parkinson Foundation</note>
</notesStmt>
<sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Paroxysmal dyskinesias in mice</title>
<author><persName><forename type="first">Thomas L.</forename>
<surname>Shirley</surname>
<roleName type="degree">PhD</roleName>
</persName>
<affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</affiliation>
</author>
<author><persName><forename type="first">Lekha M.</forename>
<surname>Rao</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</affiliation>
</author>
<author><persName><forename type="first">Ellen J.</forename>
<surname>Hess</surname>
<roleName type="degree">PhD</roleName>
</persName>
<affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</affiliation>
</author>
<author><persName><forename type="first">H. A.</forename>
<surname>Jinnah</surname>
<roleName type="degree">MD, PhD</roleName>
</persName>
<note type="correspondence"><p>Correspondence: Meyer 6‐181, Johns Hopkins University, Baltimore, Maryland 21287</p>
</note>
<affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</affiliation>
</author>
</analytic>
<monogr><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="pISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<idno type="DOI">10.1002/(ISSN)1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-01-30"></date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="259">259</biblScope>
<biblScope unit="page" to="264">264</biblScope>
</imprint>
</monogr>
<idno type="istex">BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5</idno>
<idno type="DOI">10.1002/mds.21829</idno>
<idno type="ArticleID">MDS21829</idno>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><creation><date>2008</date>
</creation>
<langUsage><language ident="en">en</language>
</langUsage>
<abstract xml:lang="en"><p>Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society</p>
</abstract>
<textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head>
<item><term>tottering</term>
</item>
<item><term>lethargic</term>
</item>
<item><term>rocker</term>
</item>
<item><term>paroxysmal dyskinesia</term>
</item>
<item><term>dystonia</term>
</item>
<item><term>channelopathy</term>
</item>
</list>
</keywords>
</textClass>
<textClass><keywords scheme="Journal Subject"><list><head>Article category</head>
<item><term>Research Article</term>
</item>
</list>
</keywords>
</textClass>
</profileDesc>
<revisionDesc><change when="2007-07-19">Received</change>
<change when="2007-10-08">Registration</change>
<change when="2008-01-30">Published</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><original>false</original>
<mimetype>text/plain</mimetype>
<extension>txt</extension>
<uri>https://api.istex.fr/document/BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5/fulltext/txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body" wicri:toSee="Element #text; element #text"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration>
<istex:document><component version="2.0" type="serialArticle" xml:lang="en"> <header> <publicationMeta level="product"> <publisherInfo> <publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName>
<publisherLoc>Hoboken</publisherLoc>
</publisherInfo>
<doi registered="yes">10.1002/(ISSN)1531-8257</doi>
<issn type="print">0885-3185</issn>
<issn type="electronic">1531-8257</issn>
<idGroup> <id type="product" value="MDS"></id>
</idGroup>
<titleGroup> <title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title>
<title type="short">Mov. Disord.</title>
</titleGroup>
</publicationMeta>
<publicationMeta level="part" position="20"> <doi origin="wiley" registered="yes">10.1002/mds.v23:2</doi>
<numberingGroup> <numbering type="journalVolume" number="23">23</numbering>
<numbering type="journalIssue">2</numbering>
</numberingGroup>
<coverDate startDate="2008-01-30">30 January 2008</coverDate>
</publicationMeta>
<publicationMeta level="unit" type="article" position="160" status="forIssue"> <doi origin="wiley" registered="yes">10.1002/mds.21829</doi>
<idGroup> <id type="unit" value="MDS21829"></id>
</idGroup>
<countGroup> <count type="pageTotal" number="6"></count>
</countGroup>
<titleGroup> <title type="articleCategory">Research Article</title>
<title type="tocHeading1">Research Articles</title>
</titleGroup>
<copyright ownership="thirdParty">Copyright © 2007 Movement Disorder Society</copyright>
<eventGroup><event type="manuscriptReceived" date="2007-07-19"></event>
<event type="manuscriptRevised" date="2007-08-24"></event>
<event type="manuscriptAccepted" date="2007-10-08"></event>
<event type="firstOnline" date="2007-11-12"></event>
<event type="publishedOnlineFinalForm" date="2008-01-25"></event>
<event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2007-11-12"></event>
<event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event>
<event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event>
<event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event>
</eventGroup>
<numberingGroup> <numbering type="pageFirst">259</numbering>
<numbering type="pageLast">264</numbering>
</numberingGroup>
<correspondenceTo>Meyer 6‐181, Johns Hopkins University, Baltimore, Maryland 21287</correspondenceTo>
<linkGroup> <link type="toTypesetVersion" href="file:MDS.MDS21829.pdf"></link>
</linkGroup>
</publicationMeta>
<contentMeta> <countGroup> <count type="figureTotal" number="2"></count>
<count type="tableTotal" number="0"></count>
<count type="referenceTotal" number="38"></count>
<count type="wordTotal" number="3950"></count>
</countGroup>
<titleGroup> <title type="main" xml:lang="en">Paroxysmal dyskinesias in mice</title>
<title type="short" xml:lang="en">Paroxysmal Dyskinesias in Mice</title>
</titleGroup>
<creators> <creator xml:id="au1" creatorRole="author" affiliationRef="#af1"> <personName> <givenNames>Thomas L.</givenNames>
<familyName>Shirley</familyName>
<degrees>PhD</degrees>
</personName>
</creator>
<creator xml:id="au2" creatorRole="author" affiliationRef="#af1"> <personName> <givenNames>Lekha M.</givenNames>
<familyName>Rao</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au3" creatorRole="author" affiliationRef="#af1"> <personName> <givenNames>Ellen J.</givenNames>
<familyName>Hess</familyName>
<degrees>PhD</degrees>
</personName>
</creator>
<creator xml:id="au4" creatorRole="author" affiliationRef="#af1" corresponding="yes"> <personName> <givenNames>H. A.</givenNames>
<familyName>Jinnah</familyName>
<degrees>MD, PhD</degrees>
</personName>
<contactDetails> <email>hjinnah@jhmi.edu</email>
</contactDetails>
</creator>
</creators>
<affiliationGroup> <affiliation xml:id="af1" countryCode="US" type="organization"> <unparsedAffiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</unparsedAffiliation>
</affiliation>
</affiliationGroup>
<keywordGroup xml:lang="en" type="author"> <keyword xml:id="kwd1">tottering</keyword>
<keyword xml:id="kwd2">lethargic</keyword>
<keyword xml:id="kwd3">rocker</keyword>
<keyword xml:id="kwd4">paroxysmal dyskinesia</keyword>
<keyword xml:id="kwd5">dystonia</keyword>
<keyword xml:id="kwd6">channelopathy</keyword>
</keywordGroup>
<fundingInfo> <fundingAgency>NIH</fundingAgency>
<fundingNumber>F32 NS52040</fundingNumber>
<fundingNumber>R01 NS40470</fundingNumber>
<fundingNumber>R01 NS33592</fundingNumber>
</fundingInfo>
<fundingInfo> <fundingAgency>Bachmann‐Strauss Dystonia & Parkinson Foundation</fundingAgency>
</fundingInfo>
<supportingInformation> <p> This article includes supplementary video clips, available online at <url href="http://www.interscience.wiley.com/jpages/0885-3185/suppmat"> http://www.interscience.wiley.com/jpages/0885‐3185/suppmat </url>
</p>
<supportingInfoItem> <mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds21829:mds21829"></mediaResource>
<caption>The first of three video segments is shown as the earlyview video segment for this article. Segment 1.The first segment of this clip shows a tottering mouse at baseline. It walks and rears with a slightly tremulous and unsteady gait. The second segment shows the early phase of an attack involving predominantly the hind limbs and caudal body. The second segment shows full body involvement at the peak of an attack. The third segment shows the late phase of an attack with predominant involvement of the forelimbs, head, neck, and jaw (Adapted from Hess and Jinnah 38 ).</caption>
</supportingInfoItem>
</supportingInformation>
<abstractGroup> <abstract type="main" xml:lang="en"> <title type="main">Abstract</title>
<p>Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society</p>
</abstract>
</abstractGroup>
</contentMeta>
</header>
</component>
</istex:document>
</istex:metadataXml>
<!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Paroxysmal dyskinesias in mice</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en"><title>Paroxysmal Dyskinesias in Mice</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Paroxysmal dyskinesias in mice</title>
</titleInfo>
<name type="personal"><namePart type="given">Thomas L.</namePart>
<namePart type="family">Shirley</namePart>
<namePart type="termsOfAddress">PhD</namePart>
<affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Lekha M.</namePart>
<namePart type="family">Rao</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Ellen J.</namePart>
<namePart type="family">Hess</namePart>
<namePart type="termsOfAddress">PhD</namePart>
<affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H. A.</namePart>
<namePart type="family">Jinnah</namePart>
<namePart type="termsOfAddress">MD, PhD</namePart>
<affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA</affiliation>
<description>Correspondence: Meyer 6‐181, Johns Hopkins University, Baltimore, Maryland 21287</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre authority="originalCategForm">article</genre>
<originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place><placeTerm type="text">Hoboken</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2008-01-30</dateIssued>
<dateCaptured encoding="w3cdtf">2007-07-19</dateCaptured>
<dateValid encoding="w3cdtf">2007-10-08</dateValid>
<copyrightDate encoding="w3cdtf">2008</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription><internetMediaType>text/html</internetMediaType>
<extent unit="figures">2</extent>
<extent unit="references">38</extent>
<extent unit="words">3950</extent>
</physicalDescription>
<abstract lang="en">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. © 2007 Movement Disorder Society</abstract>
<note type="funding">NIH - No. F32 NS52040; No. R01 NS40470; No. R01 NS33592; </note>
<note type="funding">Bachmann‐Strauss Dystonia & Parkinson Foundation</note>
<subject lang="en"><genre>Keywords</genre>
<topic>tottering</topic>
<topic>lethargic</topic>
<topic>rocker</topic>
<topic>paroxysmal dyskinesia</topic>
<topic>dystonia</topic>
<topic>channelopathy</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
</titleInfo>
<note type="content"> This article includes supplementary video clips, available online at http://www.interscience.wiley.com/jpages/0885‐3185/suppmatSupporting Info Item: The first of three video segments is shown as the earlyview video segment for this article. Segment 1.The first segment of this clip shows a tottering mouse at baseline. It walks and rears with a slightly tremulous and unsteady gait. The second segment shows the early phase of an attack involving predominantly the hind limbs and caudal body. The second segment shows full body involvement at the peak of an attack. The third segment shows the late phase of an attack with predominant involvement of the forelimbs, head, neck, and jaw (Adapted from Hess and Jinnah 38 ). - </note>
<subject><genre>article category</genre>
<topic>Research Article</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>259</start>
<end>264</end>
<total>6</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5</identifier>
<identifier type="DOI">10.1002/mds.21829</identifier>
<identifier type="ArticleID">MDS21829</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition>
<recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002958 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002958 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Istex |étape= Corpus |type= RBID |clé= ISTEX:BC5FF097585FB0A2A2D5F037E0FDF67F796B3BB5 |texte= Paroxysmal dyskinesias in mice }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |