A validation exercise on the new consensus criteria for multiple system atrophy
Identifieur interne : 002940 ( Istex/Corpus ); précédent : 002939; suivant : 002941A validation exercise on the new consensus criteria for multiple system atrophy
Auteurs : Yasushi Osaki ; Yoav Ben-Shlomo ; Andrew J. Lees ; Gregor K. Wenning ; Niall P. QuinnSource :
- Movement Disorders [ 0885-3185 ] ; 2009-11-15.
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Abstract
The revised (new) consensus clinical diagnostic criteria for multiple system atrophy (MSA) were published in 2008. To validate these criteria, we utilized the same cohort that we reported previously, which included 59 patients with a clinical diagnosis of MSA that was confirmed neuropathologically in 51 of them at the Queen Square Brain Bank for Neurological Disorders. At the first clinic visit, sensitivity with new consensus possible category was higher, and PPV marginally higher, than for clinical diagnosis and old consensus possible category. New consensus probable category showed marginally higher sensitivity than, and the same PPV as, old consensus probable category. At the last clinic visit, new consensus possible category had exactly the same sensitivity and only marginally higher PPV compared with old consensus possible category. New consensus probable category showed the same sensitivity and PPV as old consensus probable category. Our data indicate that in this case material the new consensus criteria for possible MSA could improve diagnostic accuracy at first neurological evaluation compared with the old consensus criteria. Prospective clinicopathological validation studies of the new consensus criteria, particularly incorporating in vivo structural and functional imaging results, are required to extend the current findings. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22826
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Lees</name><affiliation><mods:affiliation>Reta Lila Weston Institute for Neurological Studies, Royal Free and UCL Medical School, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Queen Square Brain Bank for Neurological Disorders, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation><mods:affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. 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Quinn</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11-15">2009-11-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2272">2272</biblScope><biblScope unit="page" to="2276">2276</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EA23B054034EF09A5E31E7B8443A7FFD42917B75</idno><idno type="DOI">10.1002/mds.22826</idno><idno type="ArticleID">MDS22826</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>autonomic failure</term><term>cerebellar ataxia</term><term>diagnostic criteria</term><term>multiple system atrophy</term><term>parkinsonism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The revised (new) consensus clinical diagnostic criteria for multiple system atrophy (MSA) were published in 2008. To validate these criteria, we utilized the same cohort that we reported previously, which included 59 patients with a clinical diagnosis of MSA that was confirmed neuropathologically in 51 of them at the Queen Square Brain Bank for Neurological Disorders. At the first clinic visit, sensitivity with new consensus possible category was higher, and PPV marginally higher, than for clinical diagnosis and old consensus possible category. New consensus probable category showed marginally higher sensitivity than, and the same PPV as, old consensus probable category. At the last clinic visit, new consensus possible category had exactly the same sensitivity and only marginally higher PPV compared with old consensus possible category. New consensus probable category showed the same sensitivity and PPV as old consensus probable category. Our data indicate that in this case material the new consensus criteria for possible MSA could improve diagnostic accuracy at first neurological evaluation compared with the old consensus criteria. Prospective clinicopathological validation studies of the new consensus criteria, particularly incorporating in vivo structural and functional imaging results, are required to extend the current findings. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Yasushi Osaki MD</name><affiliations><json:string>National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</json:string><json:string>Department of Geriatrics, Cardiology and Neurology, Kochi Medical School, Kochi, Japan</json:string></affiliations></json:item><json:item><name>Yoav Ben‐Shlomo MD</name><affiliations><json:string>Department of Social Medicine, University of Bristol, Bristol, United Kingdom</json:string></affiliations></json:item><json:item><name>Andrew J. Lees MD</name><affiliations><json:string>Reta Lila Weston Institute for Neurological Studies, Royal Free and UCL Medical School, London, United Kingdom</json:string><json:string>Queen Square Brain Bank for Neurological Disorders, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Gregor K. Wenning MSc</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Niall P. Quinn MD</name><affiliations><json:string>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diagnostic criteria</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cerebellar ataxia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autonomic failure</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The revised (new) consensus clinical diagnostic criteria for multiple system atrophy (MSA) were published in 2008. To validate these criteria, we utilized the same cohort that we reported previously, which included 59 patients with a clinical diagnosis of MSA that was confirmed neuropathologically in 51 of them at the Queen Square Brain Bank for Neurological Disorders. At the first clinic visit, sensitivity with new consensus possible category was higher, and PPV marginally higher, than for clinical diagnosis and old consensus possible category. New consensus probable category showed marginally higher sensitivity than, and the same PPV as, old consensus probable category. At the last clinic visit, new consensus possible category had exactly the same sensitivity and only marginally higher PPV compared with old consensus possible category. New consensus probable category showed the same sensitivity and PPV as old consensus probable category. Our data indicate that in this case material the new consensus criteria for possible MSA could improve diagnostic accuracy at first neurological evaluation compared with the old consensus criteria. Prospective clinicopathological validation studies of the new consensus criteria, particularly incorporating in vivo structural and functional imaging results, are required to extend the current findings. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>4.916</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1389</abstractCharCount><pdfWordCount>2528</pdfWordCount><pdfCharCount>17505</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>199</abstractWordCount></qualityIndicators><title>A validation exercise on the new consensus criteria for multiple system atrophy</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>5</total><last>2276</last><first>2272</first></pages><issn><json:string>0885-3185</json:string></issn><issue>15</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22826</json:string></doi><id>EA23B054034EF09A5E31E7B8443A7FFD42917B75</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/EA23B054034EF09A5E31E7B8443A7FFD42917B75/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/EA23B054034EF09A5E31E7B8443A7FFD42917B75/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/EA23B054034EF09A5E31E7B8443A7FFD42917B75/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A validation exercise on the new consensus criteria for multiple system atrophy</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>PSP (Europe)</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A validation exercise on the new consensus criteria for multiple system atrophy</title><author><persName><forename type="first">Yasushi</forename><surname>Osaki</surname><roleName type="degree">MD</roleName></persName><affiliation>National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</affiliation><affiliation>Department of Geriatrics, Cardiology and Neurology, Kochi Medical School, Kochi, Japan</affiliation></author><author><persName><forename type="first">Yoav</forename><surname>Ben‐Shlomo</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Social Medicine, University of Bristol, Bristol, United Kingdom</affiliation></author><author><persName><forename type="first">Andrew J.</forename><surname>Lees</surname><roleName type="degree">MD</roleName></persName><affiliation>Reta Lila Weston Institute for Neurological Studies, Royal Free and UCL Medical School, London, United Kingdom</affiliation><affiliation>Queen Square Brain Bank for Neurological Disorders, London, United Kingdom</affiliation></author><author><persName><forename type="first">Gregor K.</forename><surname>Wenning</surname><roleName type="degree">MSc</roleName></persName><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Niall P.</forename><surname>Quinn</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Box 147, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom</p></note><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11-15"></date><biblScope unit="vol">24</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2272">2272</biblScope><biblScope unit="page" to="2276">2276</biblScope></imprint></monogr><idno type="istex">EA23B054034EF09A5E31E7B8443A7FFD42917B75</idno><idno type="DOI">10.1002/mds.22826</idno><idno type="ArticleID">MDS22826</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The revised (new) consensus clinical diagnostic criteria for multiple system atrophy (MSA) were published in 2008. To validate these criteria, we utilized the same cohort that we reported previously, which included 59 patients with a clinical diagnosis of MSA that was confirmed neuropathologically in 51 of them at the Queen Square Brain Bank for Neurological Disorders. At the first clinic visit, sensitivity with new consensus possible category was higher, and PPV marginally higher, than for clinical diagnosis and old consensus possible category. New consensus probable category showed marginally higher sensitivity than, and the same PPV as, old consensus probable category. At the last clinic visit, new consensus possible category had exactly the same sensitivity and only marginally higher PPV compared with old consensus possible category. New consensus probable category showed the same sensitivity and PPV as old consensus probable category. Our data indicate that in this case material the new consensus criteria for possible MSA could improve diagnostic accuracy at first neurological evaluation compared with the old consensus criteria. Prospective clinicopathological validation studies of the new consensus criteria, particularly incorporating in vivo structural and functional imaging results, are required to extend the current findings. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>multiple system atrophy</term></item><item><term>diagnostic criteria</term></item><item><term>parkinsonism</term></item><item><term>cerebellar ataxia</term></item><item><term>autonomic failure</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-06-04">Received</change><change when="2009-09-06">Registration</change><change when="2009-11-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/EA23B054034EF09A5E31E7B8443A7FFD42917B75/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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#af5"><personName><givenNames>Andrew J.</givenNames><familyName>Lees</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Gregor K.</givenNames><familyName>Wenning</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af7" corresponding="yes"><personName><givenNames>Niall P.</givenNames><familyName>Quinn</familyName><degrees>MD</degrees></personName><contactDetails><email>n.quinn@ion.ucl.ac.uk</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="JP" type="organization"><unparsedAffiliation>Department of Geriatrics, Cardiology and Neurology, Kochi Medical School, Kochi, Japan</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="GB" type="organization"><unparsedAffiliation>Department of Social Medicine, University of Bristol, Bristol, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>Reta Lila Weston Institute for Neurological Studies, Royal Free and UCL Medical School, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="GB" type="organization"><unparsedAffiliation>Queen Square Brain Bank for Neurological Disorders, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="AT" type="organization"><unparsedAffiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="GB" type="organization"><unparsedAffiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">multiple system atrophy</keyword><keyword xml:id="kwd2">diagnostic criteria</keyword><keyword xml:id="kwd3">parkinsonism</keyword><keyword xml:id="kwd4">cerebellar ataxia</keyword><keyword xml:id="kwd5">autonomic failure</keyword></keywordGroup><fundingInfo><fundingAgency>PSP (Europe)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The revised (new) consensus clinical diagnostic criteria for multiple system atrophy (MSA) were published in 2008. To validate these criteria, we utilized the same cohort that we reported previously, which included 59 patients with a clinical diagnosis of MSA that was confirmed neuropathologically in 51 of them at the Queen Square Brain Bank for Neurological Disorders. At the <i>first</i> clinic visit, sensitivity with new consensus <i>possible</i> category was higher, and PPV marginally higher, than for clinical diagnosis and old consensus possible category. New consensus <i>probable</i> category showed marginally higher sensitivity than, and the same PPV as, old consensus probable category. At the <i>last</i> clinic visit, new consensus possible category had exactly the same sensitivity and only marginally higher PPV compared with old consensus possible category. New consensus probable category showed the same sensitivity and PPV as old consensus probable category. Our data indicate that in this case material the new consensus criteria for possible MSA could improve diagnostic accuracy at first neurological evaluation compared with the old consensus criteria. Prospective clinicopathological validation studies of the new consensus criteria, particularly incorporating in vivo structural and functional imaging results, are required to extend the current findings. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>A validation exercise on the new consensus criteria for multiple system atrophy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Validity of the New Consensus Criteria for MSA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A validation exercise on the new consensus criteria for multiple system atrophy</title></titleInfo><name type="personal"><namePart type="given">Yasushi</namePart><namePart type="family">Osaki</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</affiliation><affiliation>Department of Geriatrics, Cardiology and Neurology, Kochi Medical School, Kochi, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yoav</namePart><namePart type="family">Ben‐Shlomo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Social Medicine, University of Bristol, Bristol, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew J.</namePart><namePart type="family">Lees</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Reta Lila Weston Institute for Neurological Studies, Royal Free and UCL Medical School, London, United Kingdom</affiliation><affiliation>Queen Square Brain Bank for Neurological Disorders, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gregor K.</namePart><namePart type="family">Wenning</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Niall P.</namePart><namePart type="family">Quinn</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom</affiliation><description>Correspondence: Box 147, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-11-15</dateIssued><dateCaptured encoding="w3cdtf">2009-06-04</dateCaptured><dateValid encoding="w3cdtf">2009-09-06</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">8</extent><extent unit="words">3954</extent></physicalDescription><abstract lang="en">The revised (new) consensus clinical diagnostic criteria for multiple system atrophy (MSA) were published in 2008. To validate these criteria, we utilized the same cohort that we reported previously, which included 59 patients with a clinical diagnosis of MSA that was confirmed neuropathologically in 51 of them at the Queen Square Brain Bank for Neurological Disorders. At the first clinic visit, sensitivity with new consensus possible category was higher, and PPV marginally higher, than for clinical diagnosis and old consensus possible category. New consensus probable category showed marginally higher sensitivity than, and the same PPV as, old consensus probable category. At the last clinic visit, new consensus possible category had exactly the same sensitivity and only marginally higher PPV compared with old consensus possible category. New consensus probable category showed the same sensitivity and PPV as old consensus probable category. Our data indicate that in this case material the new consensus criteria for possible MSA could improve diagnostic accuracy at first neurological evaluation compared with the old consensus criteria. Prospective clinicopathological validation studies of the new consensus criteria, particularly incorporating in vivo structural and functional imaging results, are required to extend the current findings. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">PSP (Europe)</note><subject lang="en"><genre>Keywords</genre><topic>multiple system atrophy</topic><topic>diagnostic criteria</topic><topic>parkinsonism</topic><topic>cerebellar ataxia</topic><topic>autonomic failure</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>15</number></detail><extent unit="pages"><start>2272</start><end>2276</end><total>5</total></extent></part></relatedItem><identifier type="istex">EA23B054034EF09A5E31E7B8443A7FFD42917B75</identifier><identifier type="DOI">10.1002/mds.22826</identifier><identifier type="ArticleID">MDS22826</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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