Diffusion‐weighted imaging and magnetization transfer imaging of tardive and edentulous orodyskinesia
Identifieur interne : 002877 ( Istex/Corpus ); précédent : 002876; suivant : 002878Diffusion‐weighted imaging and magnetization transfer imaging of tardive and edentulous orodyskinesia
Auteurs : Abdesslem Khiat ; Yevgeniy Kuznetsov ; Pierre J. Blanchet ; Yvan BoulangerSource :
- Movement Disorders [ 0885-3185 ] ; 2008-07-15.
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- KwdEn :
Abstract
Oral dyskinesias occur in elderly individuals in relation to drug use (tardive dyskinesia, TD) or edentulousness (edentulous orodyskinesia, EOD) but their characterization remains incomplete. Our aim was to investigate whether magnetic resonance techniques such as diffusion‐weighted imaging (DWI) and magnetization transfer imaging (MTI) of the brain could be used to differentiate dyskinetic patients from control subjects. Eight drug‐treated patients with TD, 12 EOD patients, 8 drug‐treated patients without TD, and 10 control subjects were recruited and examined by DWI and MTI. Measurements in the caudate nucleus, putamen, and globus pallidus yielded globally different apparent diffusion coefficient (ADC) values between drug treated patients with TD and control subjects but the magnetization transfer ratios showed no significant variations. The discrimination between dyskinetic patients and control subjects offered by ADC values was however slightly poorer than the discrimination offered by the previously published choline/creatine ratios measured by MR spectroscopy in the basal ganglia. The results are consistent with the pathophysiological hypothesis of damage to cholinergic interneurons. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22081
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ISTEX:1684B43DF907122ACB9FBD79C48A5BD79BB8AFECLe document en format XML
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Our aim was to investigate whether magnetic resonance techniques such as diffusion‐weighted imaging (DWI) and magnetization transfer imaging (MTI) of the brain could be used to differentiate dyskinetic patients from control subjects. Eight drug‐treated patients with TD, 12 EOD patients, 8 drug‐treated patients without TD, and 10 control subjects were recruited and examined by DWI and MTI. Measurements in the caudate nucleus, putamen, and globus pallidus yielded globally different apparent diffusion coefficient (ADC) values between drug treated patients with TD and control subjects but the magnetization transfer ratios showed no significant variations. The discrimination between dyskinetic patients and control subjects offered by ADC values was however slightly poorer than the discrimination offered by the previously published choline/creatine ratios measured by MR spectroscopy in the basal ganglia. The results are consistent with the pathophysiological hypothesis of damage to cholinergic interneurons. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Abdesslem Khiat PhD</name><affiliations><json:string>Département de radiologie, Centre hospitalier de l'Université de Montréal (CHUM), Canada</json:string></affiliations></json:item><json:item><name>Yevgeniy Kuznetsov MD, MSc</name><affiliations><json:string>Département de radiologie, Centre hospitalier de l'Université de Montréal (CHUM), Canada</json:string></affiliations></json:item><json:item><name>Pierre J. 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Our aim was to investigate whether magnetic resonance techniques such as diffusion‐weighted imaging (DWI) and magnetization transfer imaging (MTI) of the brain could be used to differentiate dyskinetic patients from control subjects. Eight drug‐treated patients with TD, 12 EOD patients, 8 drug‐treated patients without TD, and 10 control subjects were recruited and examined by DWI and MTI. Measurements in the caudate nucleus, putamen, and globus pallidus yielded globally different apparent diffusion coefficient (ADC) values between drug treated patients with TD and control subjects but the magnetization transfer ratios showed no significant variations. The discrimination between dyskinetic patients and control subjects offered by ADC values was however slightly poorer than the discrimination offered by the previously published choline/creatine ratios measured by MR spectroscopy in the basal ganglia. The results are consistent with the pathophysiological hypothesis of damage to cholinergic interneurons. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Diffusion‐weighted imaging and magnetization transfer imaging of tardive and edentulous orodyskinesia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DWI and MTI of Dyskinesia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Diffusion‐weighted imaging and magnetization transfer imaging of tardive and edentulous orodyskinesia</title></titleInfo><name type="personal"><namePart type="given">Abdesslem</namePart><namePart type="family">Khiat</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Département de radiologie, Centre hospitalier de l'Université de Montréal (CHUM), Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yevgeniy</namePart><namePart type="family">Kuznetsov</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>Département de radiologie, Centre hospitalier de l'Université de Montréal (CHUM), Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre J.</namePart><namePart type="family">Blanchet</namePart><namePart type="termsOfAddress">MD, FRCP(C), PhD</namePart><affiliation>Service de neurologie, Centre hospitalier de l'Université de Montréal (CHUM), Canada</affiliation><affiliation>Département de stomatologie, Faculté de médecine dentaire, Université de Montréal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yvan</namePart><namePart type="family">Boulanger</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Département de radiologie, Centre hospitalier de l'Université de Montréal (CHUM), Canada</affiliation><description>Correspondence: Département de radiologie, Hôpital Saint‐Luc du CHUM, 1058 St‐Denis, Montréal, Québec, Canada H2X 3J4</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-07-15</dateIssued><dateCaptured encoding="w3cdtf">2007-04-11</dateCaptured><dateValid encoding="w3cdtf">2008-03-19</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">32</extent><extent unit="words">3635</extent></physicalDescription><abstract lang="en">Oral dyskinesias occur in elderly individuals in relation to drug use (tardive dyskinesia, TD) or edentulousness (edentulous orodyskinesia, EOD) but their characterization remains incomplete. Our aim was to investigate whether magnetic resonance techniques such as diffusion‐weighted imaging (DWI) and magnetization transfer imaging (MTI) of the brain could be used to differentiate dyskinetic patients from control subjects. Eight drug‐treated patients with TD, 12 EOD patients, 8 drug‐treated patients without TD, and 10 control subjects were recruited and examined by DWI and MTI. Measurements in the caudate nucleus, putamen, and globus pallidus yielded globally different apparent diffusion coefficient (ADC) values between drug treated patients with TD and control subjects but the magnetization transfer ratios showed no significant variations. The discrimination between dyskinetic patients and control subjects offered by ADC values was however slightly poorer than the discrimination offered by the previously published choline/creatine ratios measured by MR spectroscopy in the basal ganglia. The results are consistent with the pathophysiological hypothesis of damage to cholinergic interneurons. © 2008 Movement Disorder Society</abstract><note type="funding">Quebec Health Research Fund</note><note type="funding">Canadian Institutes of Health Research</note><subject lang="en"><genre>Keywords</genre><topic>tardive dyskinesia</topic><topic>edentulous orodyskinesia</topic><topic>diffusion‐weighted imaging</topic><topic>magnetization transfer imaging</topic><topic>basal ganglia</topic><topic>antidepressants</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1281</start><end>1285</end><total>5</total></extent></part></relatedItem><identifier type="istex">1684B43DF907122ACB9FBD79C48A5BD79BB8AFEC</identifier><identifier type="DOI">10.1002/mds.22081</identifier><identifier type="ArticleID">MDS22081</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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