Gabapentin for essential tremor: A multiple‐dose, double‐blind, placebo‐controlled trial
Identifieur interne : 002056 ( Istex/Corpus ); précédent : 002055; suivant : 002057Gabapentin for essential tremor: A multiple‐dose, double‐blind, placebo‐controlled trial
Auteurs : William Ondo ; Christine Hunter ; Kevin Dat Vuong ; Kenneth Schwartz ; Joseph JankovicSource :
- Movement Disorders [ 0885-3185 ] ; 2000-07.
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- KwdEn :
Abstract
Essential tremor (ET) is a common movement disorder that often becomes refractory to conventional pharmacologic management. Open‐label studies suggest that gabapentin is efficacious for ET, but the results of controlled trials have been mixed. To determine the efficacy and tolerability of gabapentin in ET, we conducted a double‐blind, placebo‐controlled, cross‐over trial evaluating two doses (1800 mg per day and 3600 mg per day; N = 25). Patients on other ET medications were maintained on their concurrent medications for 3 months prior to study initiation and throughout the study. Twenty patients (mean age, 69.9 ± 6.1 yrs) completed the study. Overall, patient global assessments (p <0.05), observed tremor scores (p <0.005), water pouring scores (p <0.05), and activities of daily living scores (p <0.005) significantly improved. Accelerometry scores, spirographs, and investigator global impression scores did not improve. The results were similar for high and low doses. Statistical regression models did not demonstrate any significant predictors for response. Gabapentin may be effective in some cases of ET.
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DOI: 10.1002/1531-8257(200007)15:4<678::AID-MDS1012>3.0.CO;2-0
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<front><div type="abstract" xml:lang="fr">Essential tremor (ET) is a common movement disorder that often becomes refractory to conventional pharmacologic management. Open‐label studies suggest that gabapentin is efficacious for ET, but the results of controlled trials have been mixed. To determine the efficacy and tolerability of gabapentin in ET, we conducted a double‐blind, placebo‐controlled, cross‐over trial evaluating two doses (1800 mg per day and 3600 mg per day; N = 25). Patients on other ET medications were maintained on their concurrent medications for 3 months prior to study initiation and throughout the study. Twenty patients (mean age, 69.9 ± 6.1 yrs) completed the study. Overall, patient global assessments (p <0.05), observed tremor scores (p <0.005), water pouring scores (p <0.05), and activities of daily living scores (p <0.005) significantly improved. Accelerometry scores, spirographs, and investigator global impression scores did not improve. The results were similar for high and low doses. Statistical regression models did not demonstrate any significant predictors for response. Gabapentin may be effective in some cases of ET.</div>
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<namePart type="family">Schwartz</namePart>
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<affiliation>Baylor College of Medicine, Houston, Texas, U.S.A.</affiliation>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">Joseph</namePart>
<namePart type="family">Jankovic</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Baylor College of Medicine, Houston, Texas, U.S.A.</affiliation>
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<dateIssued encoding="w3cdtf">2000-07</dateIssued>
<dateCaptured encoding="w3cdtf">1999-10-12</dateCaptured>
<dateValid encoding="w3cdtf">2000-04-11</dateValid>
<copyrightDate encoding="w3cdtf">2000</copyrightDate>
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<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<extent unit="figures">1</extent>
<extent unit="tables">2</extent>
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<abstract lang="fr">Essential tremor (ET) is a common movement disorder that often becomes refractory to conventional pharmacologic management. Open‐label studies suggest that gabapentin is efficacious for ET, but the results of controlled trials have been mixed. To determine the efficacy and tolerability of gabapentin in ET, we conducted a double‐blind, placebo‐controlled, cross‐over trial evaluating two doses (1800 mg per day and 3600 mg per day; N = 25). Patients on other ET medications were maintained on their concurrent medications for 3 months prior to study initiation and throughout the study. Twenty patients (mean age, 69.9 ± 6.1 yrs) completed the study. Overall, patient global assessments (p <0.05), observed tremor scores (p <0.005), water pouring scores (p <0.05), and activities of daily living scores (p <0.005) significantly improved. Accelerometry scores, spirographs, and investigator global impression scores did not improve. The results were similar for high and low doses. Statistical regression models did not demonstrate any significant predictors for response. Gabapentin may be effective in some cases of ET.</abstract>
<note type="funding">Parke‐Davis Pharmaceuticals</note>
<subject lang="en"><genre>Keywords</genre>
<topic>Essential tremor</topic>
<topic>Gabapentin</topic>
<topic>Accelerometry</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
</titleInfo>
<subject><genre>article category</genre>
<topic>Article</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>15</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>678</start>
<end>682</end>
<total>5</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">834F3FB52302D7533ECA27BFB9A31F46CEA1F0ED</identifier>
<identifier type="DOI">10.1002/1531-8257(200007)15:4<678::AID-MDS1012>3.0.CO;2-0</identifier>
<identifier type="ArticleID">MDS1012</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2000 Movement Disorder Society</accessCondition>
<recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
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<serie></serie>
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