Involvement of the motor cortex in pseudochoreoathetosis
Identifieur interne : 001F09 ( Istex/Corpus ); précédent : 001F08; suivant : 001F10Involvement of the motor cortex in pseudochoreoathetosis
Auteurs : Lars Timmermann ; Joachim Gross ; Frank Schmitz ; Hans-Joachim Freund ; Alfons SchnitzlerSource :
- Movement Disorders [ 0885-3185 ] ; 2001-09.
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- KwdEn :
Abstract
The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.
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DOI: 10.1002/mds.1180
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<front><div type="abstract" xml:lang="en">The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.</div>
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<p>The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (<i>P</i>
< 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.</p>
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<name type="personal"><namePart type="given">Lars</namePart>
<namePart type="family">Timmermann</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Joachim</namePart>
<namePart type="family">Gross</namePart>
<namePart type="termsOfAddress">PhD</namePart>
<affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Frank</namePart>
<namePart type="family">Schmitz</namePart>
<namePart type="termsOfAddress">MA</namePart>
<affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Hans‐Joachim</namePart>
<namePart type="family">Freund</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Alfons</namePart>
<namePart type="family">Schnitzler</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation>
<description>Correspondence: Department of Neurology, MEG‐Laboratory, Heinrich‐Heine‐University, Moorenstr. 5, 40225 Duesseldorf, Germany</description>
<role><roleTerm type="text">author</roleTerm>
</role>
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<typeOfResource>text</typeOfResource>
<genre authority="originalCategForm">article</genre>
<originInfo><publisher>John Wiley & Sons, Inc.</publisher>
<place><placeTerm type="text">New York</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2001-09</dateIssued>
<dateCaptured encoding="w3cdtf">2001-01-17</dateCaptured>
<dateValid encoding="w3cdtf">2001-04-24</dateValid>
<copyrightDate encoding="w3cdtf">2001</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
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<extent unit="figures">3</extent>
<extent unit="references">30</extent>
<extent unit="words">3290</extent>
</physicalDescription>
<abstract lang="en">The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>Pseudochoreoathetosis</topic>
<topic>MEG</topic>
<topic>deafferentation</topic>
<topic>coherence</topic>
<topic>corticomotoneuronal</topic>
<topic>finger movements</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
</titleInfo>
<subject><genre>article category</genre>
<topic>Article</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>16</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>876</start>
<end>881</end>
<total>6</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">5C46B19921B0DC658658D3BE3445A5213C4281F2</identifier>
<identifier type="DOI">10.1002/mds.1180</identifier>
<identifier type="ArticleID">MDS1180</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Movement Disorder Society</accessCondition>
<recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
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</metadata>
<serie></serie>
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