Involvement of the motor cortex in pseudochoreoathetosis
Identifieur interne : 001F09 ( Istex/Corpus ); précédent : 001F08; suivant : 001F10Involvement of the motor cortex in pseudochoreoathetosis
Auteurs : Lars Timmermann ; Joachim Gross ; Frank Schmitz ; Hans-Joachim Freund ; Alfons SchnitzlerSource :
- Movement Disorders [ 0885-3185 ] ; 2001-09.
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Abstract
The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.
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DOI: 10.1002/mds.1180
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We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Lars Timmermann MD</name><affiliations><json:string>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</json:string></affiliations></json:item><json:item><name>Joachim Gross PhD</name><affiliations><json:string>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</json:string></affiliations></json:item><json:item><name>Frank Schmitz MA</name><affiliations><json:string>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</json:string></affiliations></json:item><json:item><name>Hans‐Joachim Freund MD</name><affiliations><json:string>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</json:string></affiliations></json:item><json:item><name>Alfons Schnitzler MD</name><affiliations><json:string>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Pseudochoreoathetosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MEG</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deafferentation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>coherence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>corticomotoneuronal</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>finger movements</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P > 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-09"></date><biblScope unit="vol">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="876">876</biblScope><biblScope unit="page" to="881">881</biblScope></imprint></monogr><idno type="istex">5C46B19921B0DC658658D3BE3445A5213C4281F2</idno><idno type="DOI">10.1002/mds.1180</idno><idno type="ArticleID">MDS1180</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Pseudochoreoathetosis</term></item><item><term>MEG</term></item><item><term>deafferentation</term></item><item><term>coherence</term></item><item><term>corticomotoneuronal</term></item><item><term>finger movements</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-01-17">Received</change><change when="2001-04-24">Registration</change><change when="2001-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/5C46B19921B0DC658658D3BE3445A5213C4281F2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (<i>P</i> < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Involvement of the motor cortex in pseudochoreoathetosis</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Motor Cortex in Pseudochoreoathetosis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Involvement of the motor cortex in pseudochoreoathetosis</title></titleInfo><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Timmermann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joachim</namePart><namePart type="family">Gross</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank</namePart><namePart type="family">Schmitz</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hans‐Joachim</namePart><namePart type="family">Freund</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfons</namePart><namePart type="family">Schnitzler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University, Duesseldorf, Germany</affiliation><description>Correspondence: Department of Neurology, MEG‐Laboratory, Heinrich‐Heine‐University, Moorenstr. 5, 40225 Duesseldorf, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001-09</dateIssued><dateCaptured encoding="w3cdtf">2001-01-17</dateCaptured><dateValid encoding="w3cdtf">2001-04-24</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="references">30</extent><extent unit="words">3290</extent></physicalDescription><abstract lang="en">The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.</abstract><subject lang="en"><genre>Keywords</genre><topic>Pseudochoreoathetosis</topic><topic>MEG</topic><topic>deafferentation</topic><topic>coherence</topic><topic>corticomotoneuronal</topic><topic>finger movements</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>876</start><end>881</end><total>6</total></extent></part></relatedItem><identifier type="istex">5C46B19921B0DC658658D3BE3445A5213C4281F2</identifier><identifier type="DOI">10.1002/mds.1180</identifier><identifier type="ArticleID">MDS1180</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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